Biochemical responses of a freshwater fish Cirrhinus mrigala exposed to tris(2-chloroethyl) phosphate (TCEP)

Sutha, Jesudass; Anila, Pottanthara Ashokan; Umamaheswari, S.; Ramesh, Mathan; Narayanasamy, Arul; Poopal, Rama Krishnan; Ren, Zongming

doi:10.1007/s11356-020-09527-0

Cited by 31 publications

(13 citation statements)

References 119 publications

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“…This suggests that TPP exhibits potential adverse effects on human THs. TCEP exposure in freshwater fish has significantly decreased T4 and T3 levels . However, non-significant or negative correlations have also been observed for some OPEs in our results and in related studies.…”

Section: Resultssupporting

confidence: 92%

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Exposure to Novel Brominated Flame Retardants and Organophosphate Esters and Associations with Thyroid Cancer Risk: A Case–Control Study in Eastern China

Liu

Meng

et al. 2022

Environ. Sci. Technol.

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Novel brominated flame retardant (NBFR) and organophosphate ester (OPE) exposure may engender adverse effects on human health. However, present epidemiological information regarding the effects of such exposure is limited and controversial. In this case−control study, 481 serum samples were collected from patients with thyroid cancer (n = 242) and healthy controls (n = 239) in Shandong Province, eastern China. The levels of NBFRs and OPEs, thyroid hormones, and serum lipid parameters were measured in all the participants. Pentabromotoluene, 2,3-dibromopropyl 2,4,6 tribromophenyl ether, decabromodiphenylethane (DBDPE), tris (2-chloroethyl) phosphate (TCEP), and triphenyl phosphate (TPP) were widely detected (detection frequency > 60%) in all the participants. A significantly high risk association was found between exposure of NBFRs and OPEs (namely 1,2,3,4,5-pentabromobenzene, DBDPE, tri-n-propyl phosphate, tri[(2R)-1-chloro-2-propyl] phosphate, tris (1,3-dichloro-2-propyl) phosphate, and tris (2-butoxyethyl) phosphate) and thyroid cancer in both males and females. In the females of the control group, TCEP levels exhibited a significantly positive association with thyroid-stimulating hormone and a negative association with triiodothyronine (T3), free triiodothyronine (FT3), and free thyroxine (FT4) levels. Weighted quantile sum regression evaluated the mixed effects of the compounds on thyroid hormones levels and thyroid cancer. As a result, TPP accounted for the majority of the T3, thyroxine, and FT3 amounts. Our results suggest that NBFR and OPE exposure contributes to alterations in thyroid function, thereby increasing thyroid cancer risk.

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Section: Resultssupporting

confidence: 92%

“…TCEP exposure in freshwater fish has significantly decreased T4 and T3 levels. 66 However, non-significant or negative correlations have also been observed for some OPEs in our results and in related studies. We observed negative, albeit non-significant, correlations of TCEP levels with T3 and T4 levels.…”

Section: Association Betweensupporting

confidence: 92%

Exposure to Novel Brominated Flame Retardants and Organophosphate Esters and Associations with Thyroid Cancer Risk: A Case–Control Study in Eastern China

Liu

Meng

et al. 2022

Environ. Sci. Technol.

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“…The liver is the largest organ in fish and plays a critical role in maintaining homeostasis by balancing catabolism and anabolism as well as performing detoxification functions. − As the primary organ responsible for detoxification, it is unsurprising that the liver is the target organ of a variety of pharmaceuticals and pollutants. , However, unlike its reproductive toxicity and carcinogenicity, the hepatotoxicity of TCEP remains poorly understood. , Recently, during the screening of biochemical responses of the freshwater fish Cirrhinus mrigala to TCEP, a case study reported that exposure to TCEP at 40, 200, and 1000 μg/L for 21 days resulted in histopathological lesions in the liver along with alterations in the activities of a series of antioxidant enzymes . Although the results of this case study indicated that TCEP might be hepatotoxic to fish, whether this effect is prevalent across fish species and the underlying toxification mechanism remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“…To efficiently fulfill its metabolic functions, the liver is under sophisticated regulation of the neuroendocrine system, such as the hypothalamic–pituitary–thyroid (HPT) axis. , Briefly, thyrotropin-releasing hormone (TRH) is synthesized in the hypothalamus and delivered to the pituitary to stimulate the release of thyroid-stimulating hormone (TSH), which triggers the synthesis of triiodothyronine (T3) and thyroxine (T4). − Although far from being fully understood, the binding of thyroid hormones (mainly the bioactive form T3) to their specific receptors (TRα and TRβ) in the liver can effectively regulate the hepatic metabolism of lipids, cholesterol, and glucose, primarily by modulating the transcriptional activities of related target genes. − Thus, HPT axis dysfunction may disturb liver health. , Although a few case studies have suggested that TCEP might cause the disruption of thyroid endocrine in fish species, ,, the intrinsic association between TCEP-induced HPT axis dysfunction and potential hepatotoxicity has not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

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Tris(2-chloroethyl) Phosphate Exerts Hepatotoxic Impacts on Zebrafish by Disrupting Hypothalamic–Pituitary–Thyroid and Gut–Liver Axes

Tian

et al. 2023

Environ. Sci. Technol.

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The ubiquitous environmental presence of tris(2chloroethyl) phosphate (TCEP) poses a potential threat to animals; however, little is known about its hepatotoxicity. In this study, the effects of TCEP exposure (0.5 and 5.0 μg/L for 28 days) on liver health and the potential underlying toxification mechanisms were investigated in zebrafish. Our results demonstrated that TCEP exposure led to hepatic tissue lesions and resulted in significant alterations in liver-injury-specific markers. Moreover, TCEP-exposed fish had significantly lower levels of thyrotropin-releasing hormone and thyroid-stimulating hormone in the brain, evidently less triiodothyronine whereas more thyroxine in plasma, and markedly altered expressions of genes from the hypothalamic−pituitary−thyroid (HPT) axis in the brain or liver. In addition, a significantly higher proportion of Bacteroidetes in the gut microbiota, an elevated bacterial source endotoxin lipopolysaccharide (LPS) in the plasma, upregulated expression of LPSbinding protein and Toll-like receptor 4 in the liver, and higher levels of proinflammatory cytokines in the liver were detected in TCEP-exposed zebrafish. Furthermore, TCEP-exposed fish also suffered severe oxidative damage, possibly due to disruption of the antioxidant system. These findings suggest that TCEP may exert hepatotoxic effects on zebrafish by disrupting the HPT and gut− liver axes and thereafter inducing hepatic inflammation and oxidative stress.

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Environmentally relevant concentrations of tris (2-chloroethyl) phosphate (TCEP) induce hepatotoxicity in zebrafish (Danio rerio): a whole life-cycle assessment

Hu,

Li,

Wang

et al. 2023

Fish Physiol Biochem

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Biochemical responses of a freshwater fish Cirrhinus mrigala exposed to tris(2-chloroethyl) phosphate (TCEP)

Cited by 31 publications

References 119 publications

Exposure to Novel Brominated Flame Retardants and Organophosphate Esters and Associations with Thyroid Cancer Risk: A Case–Control Study in Eastern China

Exposure to Novel Brominated Flame Retardants and Organophosphate Esters and Associations with Thyroid Cancer Risk: A Case–Control Study in Eastern China

Tris(2-chloroethyl) Phosphate Exerts Hepatotoxic Impacts on Zebrafish by Disrupting Hypothalamic–Pituitary–Thyroid and Gut–Liver Axes

Environmentally relevant concentrations of tris (2-chloroethyl) phosphate (TCEP) induce hepatotoxicity in zebrafish (Danio rerio): a whole life-cycle assessment

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