Biochemical signs of impaired cobalamin function do not affect hematological parameters in young infants: results from a double-blind randomized controlled trial

Jenssen, Håvard; Torsvik, Ingrid Kristin; Ueland, Per Magne; Midttun, Øivind; Bjørke‐Monsen, Anne‐Lise

doi:10.1038/pr.2013.101

Cited by 4 publications

(9 citation statements)

References 29 publications

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“…Despite a biomarker profile of moderate cobalamin deficiency, growth of infants was not affected [20]. A lower iron status was found to be the main determinant of hematological parameters [20]. In support of this hypothesis, in our study, although vitamin B12 increased in all children, changes in mean hemoglobin and MCV levels were seen in a limited group.…”

Section: Discussionsupporting

confidence: 85%

“…Macrocytic anemia is confined to a severe and longstanding cobalamin deficiency in infants [19]. Jenssen et al reported that cobalamin supplementation improved all markers of impaired cobalamin function but had no effect on hematological cell counts at 4 months in infants [20]. Despite a biomarker profile of moderate cobalamin deficiency, growth of infants was not affected [20].…”

Section: Discussionmentioning

confidence: 99%

“…Jenssen et al reported that cobalamin supplementation improved all markers of impaired cobalamin function but had no effect on hematological cell counts at 4 months in infants [20]. Despite a biomarker profile of moderate cobalamin deficiency, growth of infants was not affected [20]. A lower iron status was found to be the main determinant of hematological parameters [20].…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the efficacy of parenteral and oral treatment for nutritional vitamin B12 deficiency in children

et al. 2018

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison of the efficacy of parenteral and oral treatment for nutritional vitamin B12 deficiency in children

et al. 2018

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“…Several studies have confirmed the relationship between vitamin B 12 concentration and Hb, MCV, MCH and Hct [42][43][44][45]. However, the majority of studies [46][47][48][49], as well as the recent meta-analysis [50], failed to prove such a relationship.…”

Section: Discussionmentioning

confidence: 97%

Vitamin B12 Status and Optimal Range for Hemoglobin Formation in Elite Athletes

et al. 2020

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Background: Athletes and coaches believe in the ergogenic effect of vitamin B12 (which results from enhanced erythropoiesis) and they often insist on its unjustified supplementation. Therefore, our study aimed to assess the vitamin B12 status in Polish elite athletes and its influence on red blood cell parameters. Methods: In total, 1131 blood samples were collected during six years from 243 track and field athletes divided into strength and endurance groups, as well as according to the declared use of vitamin B12 injections. Results: An average vitamin B12 concentration in all subjects was 739 ± 13 pg/mL, with no cases of deficiency. A weak but significant relationship was found between vitamin B12 and hemoglobin concentrations. A significant increase in hemoglobin appeared from very low vitamin B12 concentration and up to approx. 400 pg/mL, while hemoglobin did not significantly change from 700 pg/mL and onwards. Vitamin B12 injections were used by 34% of athletes, significantly more often by endurance than by strength athletes. In athletes who declared no use of injections, a higher concentration of vitamin B12 was observed in the endurance group. Conclusion: The main finding of the present study is the determination of the range of vitamin B12 concentration which may favor better hemoglobin synthesis in athletes. They should regularly monitor vitamin B12 concentration and maintain the range of 400–700 pg/mL as it may improve red blood cell parameters. We might suggest application of a supplementation if necessary. Special attention is required in athletes with a vitamin B12 concentration below 400 pg/mL.

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“…34 Classical signs are delayed neurodevelopment and neurological symptoms, 35 but severe cobalamin deficiency may be associated with reduced weight, length, and head circumference, 36,37 as well as macrocytic anemia. 37,38 In contrast, moderate deficiency is associated with normal or even increased weight [39][40][41] and normal hematological parameters. 40,42,43 Symptoms may appear as early as the second month of life 35,44 and include feeding difficulties, regurgitations, constipation, apathy, irritability, twitching, tremors, myoclonic jerks, and developmental delay with reduced gross motor development, as well as reduced smiling and babbling.…”

Section: Clinical Signs Of Impaired Cobalamin Status In Infantsmentioning

confidence: 99%

Defining Optimal Cobalamin Status for Neonates and Infants

Bjørke-Monsen

2024

Food Nutr Bull

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Background: An optimal cobalamin status is necessary for normal neurodevelopment. Objective: To give a description of the epidemiology, pathophysiology and diagnostic challenges related to cobalamin insufficiency in neonates and infants in order to prevent its occurence. Results: Inadequate cobalamin status is prevalent among neonates and young infants, due to a high prevalence of maternal cobalamin deficiency, exclusive breastfeeding for extended periods and late introduction of animal food. Cobalamin insufficiency is associated with delayed neurodevelopment and subtle clinical symptoms like feeding difficulties, regurgitations and constipation in young infants. Early diagnosis and treatment of impaired cobalamin status is important to prevent neurologic damage. Conclusion: Clinical suspicion of cobalamin insufficiency in infants should infer immediate biochemical testing and a plasma total homocysteine > 5.0 µmol/L indicate cobalamin insufficiency in need of intramuscular treatment with hydroxycobalamin, followed by introduction of animal food after 4 months of age.

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Biochemical signs of impaired cobalamin function do not affect hematological parameters in young infants: results from a double-blind randomized controlled trial

Cited by 4 publications

References 29 publications

Comparison of the efficacy of parenteral and oral treatment for nutritional vitamin B12 deficiency in children

Comparison of the efficacy of parenteral and oral treatment for nutritional vitamin B12 deficiency in children

Vitamin B12 Status and Optimal Range for Hemoglobin Formation in Elite Athletes

Defining Optimal Cobalamin Status for Neonates and Infants

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