Biochemical Strategies in the Search for Cognition Enhancers

Briley, Mike

doi:10.1055/s-2007-1014538

Cited by 16 publications

(5 citation statements)

References 20 publications

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“…When examining the effects on spatial memory, it was apparent that low doses of caffeine enhance performance while high doses deteriorate it. In fact, studies have concluded that activation of adenosine A 1 receptors strongly inhibits the release of acetylcholine from pyramidal hippocampal neurons [ 39 , 40 , 41 ]. Acetylcholine has been known to be important for memory storage [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Acute Administration of Caffeine: The Effect on Motor Coordination, Higher Brain Cognitive Functions, and the Social Behavior of BLC57 Mice

Almosawi

Baksh

Qareeballa

et al. 2018

Behavioral Sciences

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Excessive caffeine consumption causes adverse health effects. The effects of moderate and high doses of caffeine consumption on the motor coordination, cognitive brain functions, and the social behavior in mice were studied. Animals were divided into three groups: control group, moderate dose group (Ac MD), and high dose group (Ac HD). The animals were tested after 7 days of caffeine administration. A rotarod test for motor coordination showed that the mice of the moderate dose group could stay on the rotating rod longer before falling in comparison to the control group and the high dose group. A water maze test for learning and memory showed better performance of mice receiving the moderate dose of caffeine compared to the other groups. Animals that were administered moderate as well as high doses of caffeine showed no sociability and no preference for social novelty in the three-chamber test used to test social behavior. In an elevated plus maze test, control animals showed no anxiety-like behavior while mice from both of the groups administered with caffeine showed anxiety-like behaviors. Our data conclude that the effects of caffeine on higher brain functions depend on the administration dose. When caffeine was given in moderate doses, it resulted in enhancement of memory and motor coordination functions. However, high doses caused defects in memory and learning. The social behavior of the mice, as determined by the level of anxiety and sociability, was affected negatively by moderate as well as high dose caffeine administration.

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Section: Discussionmentioning

confidence: 99%

Acute Administration of Caffeine: The Effect on Motor Coordination, Higher Brain Cognitive Functions, and the Social Behavior of BLC57 Mice

Almosawi

Baksh

Qareeballa

et al. 2018

Behavioral Sciences

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“…Adenosine A 1 receptors are expressed densely in the cerebral cortex and hippocampus (27,28). Activation of adenosine A 1 receptors strongly inhibits the release of acetylcholine from pyramidal hippocampal neurons (29)(30)(31). Acetylcholine has been shown to be important for memory storage (32).…”

Section: Discussionmentioning

confidence: 99%

Effects of caffeine on learning and memory in rats tested in the Morris water maze

Angelucci

Cesário

Hiroi

et al. 2002

Braz J Med Biol Res

116

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We studied some of the characteristics of the improving effect of the non-specific adenosine receptor antagonist, caffeine, using an animal model of learning and memory. Groups of 12 adult male Wistar rats receiving caffeine (0.3-30 mg/kg, ip, in 0.1 ml/100 g body weight) administered 30 min before training, immediately after training, or 30 min before the test session were tested in the spatial version of the Morris water maze task. Post-training administration of caffeine improved memory retention at the doses of 0.3-10 mg/kg (the rats swam up to 600 cm less to find the platform in the test session, P£0.05) but not at the dose of 30 mg/kg. Pre-test caffeine administration also caused a small increase in memory retrieval (the escape path of the rats was up to 500 cm shorter, P£0.05). In contrast, pre-training caffeine administration did not alter the performance of the animals either in the training or in the test session. These data provide evidence that caffeine improves memory retention but not memory acquisition, explaining some discrepancies among reports in the literature. Correspondence

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“…For example, stimulation of the dorsal raphe and central injection of 5-HT impaired learning and memory (see Altman and Normile 1988;Briley 1990), whereas elevated synaptic 5-HT with reuptake inhibitors enhanced memory (Flood and Cherkin 1987;Altman and Normile 1988). In contrast, Jaffard et al (1991) reported memory impairments to 5-HT reuptake inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Enhanced delayed matching performance in younger and older macaques administered the 5-HT 4 receptor agonist, RS 17017

et al. 1998

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Recent evidence indicates that the 5-HT4 subtype of serotonin receptor may modulate central cholinergic activity in regions of the mammalian CNS important to memory such as the frontal cortex, hippocampus and amygdala. These receptors could represent targets for drugs designed for the symptomatic therapy of Alzheimer's disease (AD) and other disorders of memory. In the present study, the binding activity of RS 17017 (previously described as a selective 5-HT4 agonist) was assessed across a number of neurotransmitter receptors and binding sites, pharmacokinetic data were obtained, and the compound was evaluated in macaques for mnemonic effects via a computer-assisted delayed matching-to-sample task (DMTS). Binding data confirmed the 5-HT4 selectivity of the compound, while pharmacokinetic results revealed low oral bioavailability, but a large volume of distribution of the compound. Significant and reproducible improvements in DMTS accuracy were observed after oral administration of the compound across a dose-effect series in both younger and older monkeys. The results suggest that RS 17017 offers a potential for memory enhancement in disorders involving cognitive decline, and are consistent with a role for central 5-HT4 receptors in memory. Improvements in DMTS performance in aged monkeys may have particular implications for neurodegenerative conditions such as AD, whereas positive results in the younger monkeys indicate that RS 17017 (or similar compounds) may have additional potential in the therapeutics of memory disorders not necessarily associated with advanced age.

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Biochemical Strategies in the Search for Cognition Enhancers

Cited by 16 publications

References 20 publications

Acute Administration of Caffeine: The Effect on Motor Coordination, Higher Brain Cognitive Functions, and the Social Behavior of BLC57 Mice

Acute Administration of Caffeine: The Effect on Motor Coordination, Higher Brain Cognitive Functions, and the Social Behavior of BLC57 Mice

Effects of caffeine on learning and memory in rats tested in the Morris water maze

Enhanced delayed matching performance in younger and older macaques administered the 5-HT 4 receptor agonist, RS 17017

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