Biochemical Studies Evaluating the Antiulcerogenic Potential of Ocimum sanctum in Experimentally Induced Peptic Ulcers in Rats.

Abstract

SummaryThe effect of pretreatment with Ocimum sanctum, an herbal drug, on HCl-ethanol-induced gastric lesions in rats was investigated with respect to acid/pepsin, lipid peroxidation, antioxidant status, and glycoproteins in the gastric mucosa. The increase in volume and acidity of the gastric juice and the decrease in peptic activity in HClethanol-exposed mucosa were maintained at near normalcy in O. sanctum-pretreated mucosa. The increase in lipid peroxidation, decrease in activity of antioxidants in the ulcerated rats were maintained at normalcy in the pretreated rats. Decrease in protein and glycoprotein of the ulcerated mucosa were found to be maintained to near normal in O. sanctum-treated mucosa. These results suggest that by virtue of its ability to decrease acidity and increase the mucosal defense, the use of O. sanctum as an antiulcerogenic agent is justified.Key Words: Ocimum sanctum, gastric lesions, acid, pepsin, lipid peroxidation Peptic ulcer is a multifaceted disease with a complex pluricausal etiology that is not fully understood. The last several decades have witnessed enormous progress in ulcer drug discovery and development, including a Nobel prize to Sir James Black for his seminal work on histamine H2 receptors and their blockers, a mainstay of current drug management of ulcers. Despite these advances, the ulcer remains somewhat of a medical enigma [1].Peptic ulcer refers to the group of ulcerative disorders of the upper gastrointestinal tract involving principally the most proximal portion of the duodenum and the stomach, which have in common the participation of acid/pepsin [2]. It occurs

Protective effect of glucosamine against ibuprofen‐induced peptic ulcer in rats

“…This indicated that administration of ibuprofen caused the corrosion of gastric mucosa, resulting in the disruption and disintegration of gastric mucosal cells. Similar observations have been reported earlier 22 . The ulcerative lesions observed in the gastrointestinal tract may also be associated with increased loss of protein.…”

“…Similar observations have been reported earlier. 22 The ulcerative lesions observed in the gastrointestinal tract may also be associated with increased loss of protein. According to Davenport's concept of H + release, histamine stimulates cholinergic nerves with a resulting stimulation of acid secretion, an increase in mucosal blood flow, and an increase in capillary permeability.…”