Biochemical studies of toxic agents. 5. Observations on the fate of 35S-labelled arylsulphuric acids following their administration to the rat

Hawkins, Joyce B.; Young, L.

doi:10.1042/bj0560166

Cited by 33 publications

(3 citation statements)

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“…A solution of the sulphate ester in 6ml of 2M-HCI was evaporated to dryness on a boiling-water bath and the residue was dissolved in water. The sulphate was precipitated as the benzidine salt, which was separated and titrated with 25mM-NaOH as described by Hawkins & Young (1954).…”

Section: Methodsmentioning

confidence: 99%

Formation of mercapturic acids in rats after the administration of aralkyl esters

Clapp

Young

1970

Biochemical Journal

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1. Benzylmercapturic acid and hippuric acid were isolated from the urine of rats that had been injected subcutaneously with benzyl acetate. 2. 1-Menaphthylmercapturic acid and 1-naphthoic acid were isolated from the urine of rats after the subcutaneous injection of each of the following compounds: 1-menaphthyl alcohol and its acetate, propionate, butyrate and benzoate esters. 3. A quantitative method for determining 1-menaphthylmercapturic acid in urine was developed and used to measure the excretion of this compound in the urine of rats in the 4-day period after the subcutaneous injection of 1-menaphthyl alcohol and its acetate, propionate, butyrate and benzoate esters. 4. Chromatographic evidence was obtained for the presence of S-(1-menaphthyl)glutathione and S-(1-menaphthyl)-l-cysteine in bile collected from rats with cannulated bile ducts after the animals had been injected subcutaneously with each of the following compounds: S-(1-menaphthyl)glutathione, 1-menaphthyl acetate, propionate and butyrate. 5. Benzylmercapturic acid and 1-menaphthylmercapturic acid were isolated from the urine of rats that had been injected with sodium benzyl sulphate and sodium 1-menaphthyl sulphate respectively.

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Section: Methodsmentioning

confidence: 99%

Formation of mercapturic acids in rats after the administration of aralkyl esters

Clapp

Young

1970

Biochemical Journal

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“…Chemicals. Radioactively labeled sulfate esters were prepared from 35S-labeled sulfuric acid (98%) or chlorosulfonic acid (Radiochemical Centre, Amersham, Bucks., U.K.) by the following methods: choline [35S]sulfate, 13.6 ,tCi/mg (29); dipotassium 2hydroxy-5-nitrophenyl [35S]sulfate, 10.8 ,.Ci/mg (15); potassium dodecyl [35S]sulfate, 18.1 /Ci/mg (2); potassium p-nitrophenyl [U5S]sulfate, 13.1 ,zCi/mg (11); potassium glucose [6-35S]sulfate, 10 ,uCi/ mg (24); potassium phenyl [35S]sulfate, 15.8 ,tCi/ mg (19); potassium L-tyrosine O-L35S]sulfate, 3.7 ,mCi/ mg (6). Potassium tyrosylglycine 0-[V5S]sulfate (3.12 ,Ci/mg) was prepared by the method employed for L-tyrosine 0-sulfate but substituting equimolar quantities of tyrosylglycine for L-tyrosine.…”

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Liberation of sulfate from sulfate esters by soils

Houghton¹,

Rose²

1976

Appl Environ Microbiol

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When incubated with acid, alkaline, and neutral soils, a variety of synthetic sulfate esters representing the various classes of these compounds was hydrolyzed by enzymes, probably of microbial origin. The appearance of sulfate in the soil water occurred immediately after introduction into the soils with some esters, whereas with others it occurred only after lag periods. Heat treatment destroyed the hydrolytic activity in the soils. The ester sulfate groups-present in humic acid extracted from the soil appeared to be resistant to hydrolysis by a variety of sulfohydrolases extracted from bacteria and other organisms.

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“…From the few studies which have been made on the metabolic fate of arylsulphates it would appear, at first sight, that the esters of phenols which can be regarded as 'non-physiological' (e.g. phenyl and naphthyl sulphates) are not appreciably hydrolysed in vivo (Sperber, 1948;Garton & Williams, 1949;Hawkins & Young, 1954). In contrast, esters of physiologically active phenols (e.g.…”

Section: Pmentioning

confidence: 99%

Proceedings of the Biochemical Society

1959

Biochemical Journal

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The Ealzor8 of the Biochemical Journal accept no respon8ibility for the Report8 of the Proceeding8 of the Societyl PROCEEDINGS OF THE BIOCHEMICAL SOCIETY The 386th Meeting of the Society was held in conjunction with the second Scandinavian Summer Meeting of Biochemiats, Pharmacologits, and Physiologists in Turku (Abo), Finland from Thursday, 27 August to Saturday, 29 August. The following papers were read by members of The Biochemical Society: * Indicates that the member received a grant from the Travel Fund of the Society. COMMUNICATIONS The Use of a Perfusion Apparatus to Study Continuously the Transport of 1311-Labelied Iodide by the Small Intestine.

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Biochemical studies of toxic agents. 5. Observations on the fate of 35S-labelled arylsulphuric acids following their administration to the rat

Cited by 33 publications

References 5 publications

Formation of mercapturic acids in rats after the administration of aralkyl esters

Formation of mercapturic acids in rats after the administration of aralkyl esters

Liberation of sulfate from sulfate esters by soils

Proceedings of the Biochemical Society

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