Biochemieal, endocrine, and other indices during quinestrol therapy

Danowski, T. S.; Kenny, Frederic M.; Wilson, H. R.; Sabeh, G.; Sunder, J. H.; Corredor, D.G.

doi:10.1002/cpt1970112260

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…t33.2 ± 15.3 (10) t3.4 ± 3.0 (10) t 18.6 ± 11.9 (10) t6.2 ± 6.3 (10) "9.7 ± 0.4 (11) "9.3 ± 0.3 (11) t3.7 ± 0.4 (11) *2.9 ± 0.4 (11) 112 ± 44 (10) 142 ± 53 (10) "315 ± 47 ( 7) "411 ± 93 ( 7) 12 months X ± SD (n) "2l.7 ± 13.1 (11) "33.7 ± 5.3 (11) fl4.8 ± 7.9 ( 8) t30.8 ± 7.9 ( 8) "7.9 ± 5.8 (11) "18.0 ± 14.8 (11) 52.3 ± 20.7 (11) 66.5 ± 16.6 (11) 459 mg Cortrosyn in 2 minutes with measurement af plasma 11 (OH) corticosteroids at 3 hours. ception of vibrations assessed by Bio-Thesiometer 2 ) , and oscillometric readings did not indicate any consistent trends.…”

Section: Resultsmentioning

confidence: 99%

Ether derivatives of a progestin and estrogen in monthly dosage

Danowski

Wilson

Vester

et al. 1973

Clin Pharma and Therapeutics

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Section: Resultsmentioning

confidence: 99%

Ether derivatives of a progestin and estrogen in monthly dosage

Danowski

Wilson

Vester

et al. 1973

Clin Pharma and Therapeutics

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“…Quinestrol is a synthetic estrogen (Danowski et al . 1970). It was originally administered to women as an oral contraceptive in combination with the synthetic progesterone levonorgestrel (Greenblatt 1967).…”

Section: Introductionmentioning

confidence: 99%

Assessment of non‐target toxicity effects of synthetic estradiol, quinestrol, in chickens

Zhou

Wang

et al. 2021

Integr. Zool.

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Fertility control agents for the management of rodent populations are developing and maturing. Investigating the impacts on non-target species of consumption of these agents is essential. The present study assessed the nontarget toxicity effects of quinestrol, a synthetic estrogen-based antifertility agent for managing rodent populations. Various quinestrol doses administered to male and female (n = 60 each) chickens through single oral gavage were 0 (A), 10 (B), 50 (C), and 150 (D) mg/kg body weight. Chickens were assessed for effect on body weight, weight of vital and reproductive organs, reproductive hormones, histology of reproductive organs and egg laying rates after 15, 30, and 135 days of treatment. Quinestrol did not induce mortality in chickens and its effects were time and dose dependent. The 90% egg-laying rates were delayed by 30, 60 for groups B and C compared with the control group, and group D did not reach the 90% egg-laying rate by 135 days. Reproductive organs in males and females returned to normal levels within 30 and 135 days, respectively. With the exception of the FSH concentration in group D, reproductive hormones of both sexes were similar to controls by 30 days. No other significant effects were found. The present research demonstrated the safety of quinestrol on non-target species and facilitates recommendations for the general administration of quinestrol for rodent pest management.

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Response of serum cholesterol and triglycerides to hormone treatment and the relation of pretreatment values to mortality in patients with prostatic cancer

Seal

Doe

Byar

et al. 1976

Cancer

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Cholesterol and triglycerides were measured in plasma samples from patient with cancer of the prostate before and after 3 months treatment with either Premarin, Provera, Provera and diethylstilbestrol, or diethylstilbestrol alone. Cholesterol was also measured before and after one of three doses of diethylstilbestrol or placebo. Pretreatment cholesterol levels at 196 +/- 1.3 mg per 100 ml (X +/- SE, N = 1093) were significantly lower than these reported for similar age group noncancer controls. Significant increases occurred with some of the estrogen treatments. Pretreatment cholesterol levels showed a significant negative correlation with age in Stage III and IV patients of both studies and a positive correlation with hemoglobin in Stage III patients of both studies. Pretreatment triglyceride levels at 120 +/- 1.9 mg per 100 ml (X +/- SE, N = 1089) were similar to levels reported for noncancer controls of similar age. Estrogen treatment produced a significant increase in triglyceride levels. Serum triglycerides were significantly correlated with hemoglobin, weight, and cholesterol and negatively correlated with age, Analysis of covariance for both cholesterol and triglycerides showed highly significant treatment effects, but no stage effects and no stage-treatment interactions. It showed that the pretreatment value is of extreme importance for predicting or explaining the 3-month value. Death rates were calculated by level of pretreatment cholesterol or pretreatment triglycerides for all Stage II and IV patients, all treatments combined, and for Study 2 and Study 3 separately. No consistent trends were evident for cholesterol. Spearman correlation coefficients between category of initial triglyceride value and rank of death rate were computed to test for a quadratic effect. When the absolute values of the initial triglyceride values minus the overall mean were correlated with the death rate, a significant negative correlation was found for all causes of death and for deaths due to cardiovascular disease and prostatic cancer. These results indicate that the death rate is highest near the overal mean for initial triglyceride values and decreases as the initial values deviate above or below the mean. Initial triglyceride levels appear to have potential as indicators of risk of death in patients with prostatic cancer. The percentage of patients dead at 1 year by initial triglyceride levels, measured only in Study 3, revealed a pattern similar to that observed for the death rate, that is, the highest percentages were associated with values near the overall mean.

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Biochemieal, endocrine, and other indices during quinestrol therapy

Cited by 6 publications

References 11 publications

Ether derivatives of a progestin and estrogen in monthly dosage

Ether derivatives of a progestin and estrogen in monthly dosage

Assessment of non‐target toxicity effects of synthetic estradiol, quinestrol, in chickens

Response of serum cholesterol and triglycerides to hormone treatment and the relation of pretreatment values to mortality in patients with prostatic cancer

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