Biochemistry and Genetics of the ABO, Lewis, and P Blood Group Systems

Watkins, Winifred M.

doi:10.1007/978-1-4615-8288-5_1

Cited by 269 publications

(268 citation statements)

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“…In individuals who express Lewis blood group antigens, the corresponding aI1,4)FT activity can be found in a variety of secretions and tissues (Watkins 1980;Johnson et al 1981;Prieels et al 19811. By contrast, roughly 10% of Caucasian individuals do not express Lewis antigens (Watkins 1980} or detectable a(1,41FT activity {Johnson et al 1981.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, it is worth noting that polymorphism in the expression of glycosyltransferases occurs in many organisms, including man (Watkins 1980), mouse (Ponder et al 1985), and some plants (Brederode and Nigtevecht 1974). It is also interesting to note that many humans are amorphic for one or more oligosaccharide blood group antigens and are presumably homozygous for null alleles at the glycosyltransferase loci that determine their biosynthesis (Watkins 1980;Sadler 1984).…”

Section: Discussionmentioning

confidence: 99%

“…These patterns are discernible first on the surfaces of preimplantation and early postimplantation embryomc cell aggregates (Bird and Kimber 1984;Fenderson et al 1984;Pennington et al 1985;Fenderson et al 1986;Kimber 1986). In the mature organism, expression of distinct oligosaccharide moieties ultimately becomes restricted to specific cell types (Szulman 1960(Szulman , 1962Watkins 1980;Dodd and Jessel 1985). Malignant transformation often imposes disorder on the adult patterns to yield aberrant oligosaccharide structures (Hakomori 1984;Kim et al 1988).…”

mentioning

confidence: 99%

“…This reaction attaches fucose in ~ anomeric glycosidic linkage to the C3 hydroxyl of the GlcNAc moiety (Table 1). A related structure, the Lewis a determinant (Table 1), is likewise constructed from type I precursors (terminating in lacto-N-biose I moieties, Table 1) by an ~(1,4)fucosyltransferase [~(1,4)FT] that is thought to be the product of the human Lewis blood group locus (Watkins 1980). Interestingly, this enzyme apparently copurifies with an a(1,3)FT acHuman eDNA determines SSEA-1 expression tivity that is also determined by the Lewis locus {Johnson et al 1981;Prieels et al 1981;Johnson and Watkins 1982}.…”

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confidence: 99%

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A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.

Kukowska-Latallo¹,

Larsen²,

Nair³

et al. 1990

Genes Dev.

491

274

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The stage-specific embryonic antigen SSEA-I is a cell-surface oligosaccharide molecule expressed with temporal precision during the murine preimplantation period and implicated in adhesive events involving the process of compaction. We used a mammalian transient expression system to isolate a cloned human cDNA that determines expression of the SSEA-I molecule. The cDNA sequence predicts a type II transmembrane protein with a domain structure similar to mammalian glycosyltransferases, but without primary sequence similarity to these enzymes. The carboxy-terminal domain of this protein was shown to be catalytically active as a fucosyltransferase when expressed in COS-I cells as a portion of a secreted protein A fusion peptide. The enzyme is an exceptional glycosyltransferase in that it can use both type I and type II oligosaccharides as acceptor substrates to generate subterminal Fucc~(l,4)-and Fuc~(l,3)-linkages, respectively, in a manner analogous to the human Lewis blood group fucosyltransferase. Southern blot analysis shows that the cDNA corresponds to sequences syntenic to the Lewis locus on chromosome 19. These results indicate that this cDNA is the product of the human Lewis blood group locus, provide genetic confirmation of the hypothesis that this enzyme can catalyze two distinct transglycosylation reactions, and outline an approach to the isolation of other sequences that determine expression of developmentally regulated oligosaccharide antigens.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.

Kukowska-Latallo¹,

Larsen²,

Nair³

et al. 1990

Genes Dev.

491

274

View full text Add to dashboard Cite

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“…The H enzyme is responsible for the expression of the H antigen in tissues derived from mesoderm and ectoderm, such as erythrocytes and vascular endothelial cells, and the Se enzyme for the expression of the same antigen in tissues derived from endoderm, such as epithelial cells of the digestive tract and exocrine glands (Watkins, 1980;Oriol et al, 1981Oriol et al, , 1986. The H and Se genes, and the Sec1 pseudogene constitute a cluster on the long arm of human chromosome 19 (19q13.3), where H is telomeric (Ball et al, 1991;Rouquier et al, 1994Rouquier et al, , 1995ReguigneArnould et al, 1995ReguigneArnould et al, , 1996.…”

Section: Introductionmentioning

confidence: 99%

Divergent evolution and purifying selection of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini)

Borges

Harada

2004

Genet. Mol. Biol.

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In the present study, the coding region of the H gene was sequenced and analyzed in fourteen genera of New World primates (Alouatta, Aotus, Ateles, Brachyteles, Cacajao, Callicebus, Callithrix, Cebus, Chiropotes, Lagothrix, Leontopithecus, Pithecia, Saguinus, and Saimiri), in order to investigate the evolution of the gene. The analyses revealed that this coding region contains 1,101 nucleotides, with the exception of Brachyteles, the callitrichines (Callithrix, Leontopithecus, and Saguinus) and one species of Callicebus (moloch), in which one codon was deleted. In the primates studied, the high GC content (63%), the nonrandom distribution of codons and the low evolution rate of the gene (0.513 substitutions/site/MA in the order Primates) suggest the action of a purifying type of selective pressure, confirmed by the Z-test. Our analyses did not identify mutations equivalent to those responsible for the H-deficient phenotypes found in humans, nor any other alteration that might explain the lack of expression of the gene in the erythrocytes of Neotropical monkeys. The phylogenetic trees obtained for the H gene and the distance matrix data suggest the occurrence of divergent evolution in the primates.

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Characterization of a monoclonal antibody specific for H type 2 structure of ABO blood group, and its use for measuring H type 2 on human red blood cells

Liu

Akiyama

et al. 1996

J. Clin. Lab. Anal.

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A monoclonal antibody 3A5 specific for the human red blood cells was produced by immunizing BALB/c mouse with human erythrocyte membranes of group O following the immunization protocol of selectively killing the antigen‐stimulated lymphocytes. The monoclonal antibody 3A5 we obtained agglutinated red blood cells regardless of individuals of blood group A, B, or O types, but not those from a person with a rare para‐Bombay type which is the H‐deficient phenotype. The hemagglutination reaction of 3A5 was not inhibited by saliva from either secretor or nonsecretor individuals. The specificity of 3A5 was studied by adsorption with and elution from synthetic oligosaccharide immunoadsorbents including H disaccharide, and H type 1, 2, 3, and 4 structures. Also, the reactivity of 3A5 with synthetic oligosaccharide‐BSA complexes for H type 1, H type 2, Lea, Leb, A, and B was determined by an immunoassay. We found that 3A5 did not react with any of these synthetic oligosaccharides except H type 2. From these results, the antigenic epitope recognized by 3A5 was demonstrated to be the H type 2 structure. Additionally, the H type 2 substance on erythrocytes was quantitatively analyzed using 3A5. © 1996 Wiley‐Liss, Inc.

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Biochemistry and Genetics of the ABO, Lewis, and P Blood Group Systems

Cited by 269 publications

References 280 publications

A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.

A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.

Divergent evolution and purifying selection of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini)

Characterization of a monoclonal antibody specific for H type 2 structure of ABO blood group, and its use for measuring H type 2 on human red blood cells

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