Biochemistry: Index of the Functional State of the Heart?

Isselhard, W.

doi:10.1093/bja/60.suppl_1.23s

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…Previous studies indicated that an ATP reduction of 30% to 40% is certainly compatible with cellular survival in early ischemia and in the postischemic recovery phase, but it does affect cellular function. 15 It is not until ATP levels are between 2 and 4 µmol/g dry weight that complete metabolic and functional recovery is unlikely. 15 None of the children in this study experienced a drop of their ATP to this level, which would suggest that metabolic recovery is expected in these children.…”

Section: Discussionmentioning

confidence: 99%

“…15 It is not until ATP levels are between 2 and 4 µmol/g dry weight that complete metabolic and functional recovery is unlikely. 15 None of the children in this study experienced a drop of their ATP to this level, which would suggest that metabolic recovery is expected in these children. However, with 15 minutes of reperfusion, the best recovery of ATP level as a percentage of baseline value was in the acyanotic group in which 70% of the baseline ATP was restored compared with only 47% to 59% in the cyanotic groups.…”

Section: Discussionmentioning

confidence: 99%

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Does the degree of cyanosis affect myocardial adenosine triphosphate levels and function in children undergoing surgical procedures for congenital heart disease?

Najm

Wallen

Belanger

et al. 2000

The Journal of Thoracic and Cardiovascular Surgery

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Does the degree of cyanosis affect myocardial adenosine triphosphate levels and function in children undergoing surgical procedures for congenital heart disease?

Najm

Wallen

Belanger

et al. 2000

The Journal of Thoracic and Cardiovascular Surgery

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“…basis, it is difficult to say which, if any, of the parameters (cyclic AMP, cyclic GMP, cyclic AMP/cyclic GMP) is the most important index in monitoring myocardial performance as a consequence of thermal injury. Recent studies, have shown that the relationship between myocardial metabolism, in particular the myocardial status of energy-rich substrates and phosphates and myocardial function, is not as clearly defined as had been thought (Isselhard, 1988).…”

Section: Discussionmentioning

confidence: 94%

Thermal trauma alters myocardial cyclic nucleotides and protein content in mice

Tomera

Martyn

1990

British J Pharmacology

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1 This study tested the hypothesis that the systemic effects of burn include altered metabolic activity in the heart. Metabolic activity was studied by measuring alterations in cyclic nucleotide levels and protein concentrations in atrial and ventricular muscle in mice at 14 and 22 days after a 20% body surface area (BSA) burn. Thermal injury was produced on the dorsal surface of anesthetized male CD mice by immersion in water at 95°C for 8s. This resulted in a full-thickness, 3°scald burn. In atrial and ventricular tissues, levels of adenosine 3': 5'-cyclic monophosphate (cyclic AMP) and guanosine 3': 5'-cyclic monophosphate (cyclic GMP) were analyzed by 125I-radioimmunoassay. 2 The protein content (mg prot g-dry wt) increased in the atria. The cyclic AMP content (nmol g-dry wt) was significantly increased fourfold and ninefold at 14 and 22 days, respectively, in atria from burned animals compared to controls. The cyclic AMP/cyclic GMP ratios were similarly increased.3 In the ventricle, the protein content and cyclic AMP levels were not altered, but the cyclic AMP/cyclic GMP ratios (nmol g ' dry wt) were increased at both 14 and 22 days. These changes both in atria and ventricles were less prominent when cyclic nucleotide concentrations or ratios were expressed as pmol mg-1 protein.4 The data confirm the hypothesis that a 20% BSA thermal injury evokes effects in sites remote from burn injury such as in the atria and ventricles. These effects include total body weight loss, elevated cyclic AMP, cyclic AMP/cyclic GMP ratios, and protein levels in the atria, and elevated cyclic AMP/cyclic GMP ratios in both atrial and ventricular tissues at 2 and 3 weeks after thermal injury. To prevent underestimation of cyclic nucleotide levels such changes should preferably be expressed on a prot g-dry weight basis.

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“…Σημεία ελέγχου της διακινήσεως γλυκόζης 1) Εξοκινάση: Μετά την την είσοδο στο κύτταρο, η γλυκόζη μετατρέπεται σε γλυκόζη-6-Ρ με τη βοήθεια της εξοκινάσης. Η αντίδραση αυτή απαιτεί την 41 . Έτσι, στον σκύλο παρατηρείται ότι μετά από απόφραξη του προσθίου κατιόντος για 30 ή 60 λεπτά, η επάνοδος των τιμών του ΑΤΡ και των αδενινικών νουκλεοτιδίων στις φυσιολογικές τιμές απαιτεί 14 ημέρες 87 .…”

Section: ü)unclassified

Επίδραση Αλοθανίου Και Ισοφλουρανίου Στο Μεταβολισμό Του Μυοκαρδίου Σε Ασθενείς Με Στεφανιαία Νόσο

Καρανικόλας¹

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Επίδραση αλοθανϊου και ισοφλουρανϊου στο μεταβολισμό του μυοκαρδίου σε ασθενείς με στεφανιαία νόσο.-Διδακτορική Διατριβή iii) Δεδομένα από μελέτες στον άνθρωπο 47 ίν) Απελευθέρωση γαλακτικού και μυοκαρδιακή ισχαιμία 48 ν) Είναι η απελευθέρωση γαλακπκού αξιόπιστος δείκτης μυοκαρδιακής ισχαιμίας; 49 7. Ελεύθερα λιπαρά οξέα (FFAs) 50 i) Διακίνηση 50 ii) Μεταβολισμός 51 iii) Κλινική σημασία 51 8. Κετονοσώματα: Ακετοξεικό και β-υδροξυβουτυρικό 52 9. Αμινοξέα 53 i) Γενικές αρχές 53 Η) Αλανίνη, Γλουταμικό, Γλουταμίνη 57 iii) Ασπαρτικό, Σουκινικό 60 ίν) Αμινοξέα διακλαδισμένης αλύσου: Βαλίνη, Λευκίνη, Ισολευκίνη 60 ν) Αρωματικά αμινοξέα: Φαινυλαλανίνη, Τυροσΐνη, Τρυπτοφάνη 60 vi) Αργινίνη

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Biochemistry: Index of the Functional State of the Heart?

Cited by 7 publications

References 15 publications

Does the degree of cyanosis affect myocardial adenosine triphosphate levels and function in children undergoing surgical procedures for congenital heart disease?

Does the degree of cyanosis affect myocardial adenosine triphosphate levels and function in children undergoing surgical procedures for congenital heart disease?

Thermal trauma alters myocardial cyclic nucleotides and protein content in mice

Επίδραση Αλοθανίου Και Ισοφλουρανίου Στο Μεταβολισμό Του Μυοκαρδίου Σε Ασθενείς Με Στεφανιαία Νόσο

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