Biochemistry of Inorganic Fluoride

Kirk, Kenneth L.

doi:10.1007/978-1-4684-5817-6_2

Cited by 26 publications

(17 citation statements)

References 128 publications

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“…Fluoride anion plays a role in dental health [21] and has potential use for the treatment of osteoporosis [18b] Fluoride is also a product of the hydrolysis of sarin and soman (G-type nerve agents), and consequently, the ability to monitor fluoride in victims and surrounding environments after a terrorist incident using this nerve gas is of great value. [22] Thus, fluoride chemosensors are in high demand due to their importance in a variety of healthcare and environmental contexts.…”

Section: Fluoride Self-propagating Cascadesmentioning

confidence: 99%

Self‐propagating amplification reactions for molecular detection and signal amplification: Advantages, pitfalls, and challenges

Sun

Shabat

Phillips

et al. 2018

J of Physical Organic Chem

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Self-propagating cascade reactions are a recent development for chemo-sensing protocols. These cascade reactions, in principle, offer low limits of detection by virtue of exponential signal amplification, and are initiated by a specific, pre-planned molecular detection event. This combination of selectivity for a detection event followed by in situ signal amplification is achieved by exploitation of mechanistic organic chemistry, and thus has resulted in various chemo-sensing protocols that employ one or more reagents to achieve the desired selectivity and sensitivity for an assay. Species such as hydrogen peroxide, thiols, and fluoride, have been used as active reagents to initiate the first examples of self-propagating signal amplification reactions, although many other active reagents should be compatible with the approaches. A common feature of the reagents that support the self-propagating signal amplification reactions is the involvement of quinonemethide intermediates resulting from elimination of optical reporters and/or active reagents, where the latter propagates the signal amplification reaction. The early examples of these amplification sequences, however, are slow to reach full signal, thus leaving time for background reactions to generate non-specific signals. This issue of background has limited practical applications of these self-propagating signal amplification reactions, as has challenging synthetic routes to the reagents, as well as the potential for other chemical species to interfere with the detection and signal amplification processes. Thus, the goal of this review is to summarize the progress of self-propagating signal amplification technology, identify the pitfalls of current designs, and by doing so, to stimulate future studies in this growing and promising research area.

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Section: Fluoride Self-propagating Cascadesmentioning

confidence: 99%

Self‐propagating amplification reactions for molecular detection and signal amplification: Advantages, pitfalls, and challenges

Sun

Shabat

Phillips

et al. 2018

J of Physical Organic Chem

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“…Despites these pivotal roles, it's metabolic deregulation, deficiency or excess ensuing various disorders like ischemic stroke, epilepsy, growth retardation, infantile diarrhea, skin and neurological diseases . On the other hand, anions are essential for life, as many biological and physiological processes depend on anions . It is well established that both excess and deficiency of anionic species lead several diseases like fluorosis, kidney disorder, bone and skeletal cancer etc .…”

Section: Introductionmentioning

confidence: 99%

A Multifunctional Carbohydrazide‐Based Chromofluorescent Sensor for the Selective Detection of Cu(II) and Zn(II) Ion

et al. 2017

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A series of multifunctional carbohydrazide based chromofluorescent sensor molecules derived from carbohydrazide, 4‐formyl‐1‐substituted phenyl‐pyrazole‐3‐carboxylate and 2‐hydroxy‐naphthaldehyde were successfully designed and synthesized. The synthesized sensor molecules exhibit significant red shift in their absorption spectra with visual color changes on interaction with Cu(II) and Zn(II) ions. In addition, the optimized sensor showed excellent selectivity towards Cu(II) and Zn(II) ions with fluorescence “turn off” and “turn on” modes respectively. Along with this, anion recognition studies were carried out using UV‐visible and fluorescence spectrophotometric titrations which revealed that synthesized sensors also exhibit selective sensing of F−, CH3COO− and H2PO4− ions via H‐bond interaction and subsequent deprotonation to elicit distinct visual color change from light yellow to orange with significant quenching in its emission intensity. Furthermore, the in‐situ prepared sensor‐anion adduct solution exhibited colorimetric “On‐Off” sensing of Cu(II) and Zn(II) ions, which was confirmed through UV‐visible titration experiments.

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“…1 Among halides, fluoride (F¯) continues to receive much attention due to its wide spread applications in dental care, and its role in certain enzyme inhibitions. [2][3][4] Similarly, acetate ion (AcO¯) plays an important role in many metabolic processes. It has also been known to serve as a tracer for certain malignancies.…”

Section: Introductionmentioning

confidence: 99%

“…The mixture was cooled to room temperature to get precipitate of corresponding quinoxalinium salt. The resulting salt was further washed with cold toluene or hexane, dried to afford(1)(2)(3)(4)(5) in 40-64% yield over three steps. The final compounds 1-5 were characterized with 1 H, 13 C-NMR, IR, UV spectroscopy and mass spectrometry.…”

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confidence: 99%

Novel quinoxaline based chemosensors with selective dual mode of action: nucleophilic addition and host–guest type complex formation

et al. 2016

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§ Shared first author(contributed equally) * AbstractNew quinoxalinium salts 1-5 as chemosensors have been exploited via naked eye, UV-Vis absorption, fluorescence quenching and 1 H NMR experiments. New sensors 1-5 showed dual mode, nucleophilic addition and host-guest type complex towards anion (F¯, AcO¯ and ascorbate) detection. Small anions (F¯/AcO¯) showed nucleophilic addition at C2 position of quinoxalinium cation, while larger anion (ascorbate), revealed the formation of host-guest type complex due to steric hindrance posed by C3 of phenyl ring. Nucleophilic addition of small anions (F¯/AcO¯) leads to de-aromatization of quinoxalinium cation. However in the case of larger anion, ascorbate, host-guest type complex formation induces changes in absorption/fluorescence signals of quinoxalinium moiety. This selective binding has been confirmed on the basis of 1 H NMR spectroscopic technique, whereupon nucleophilic addition of small anions (F¯/AcO¯) was confirmed by monitoring characteristic proton NMR signals of H a and methylene protons (CH 2 ), which were clearly shifted in case of fluoride and acetate ions addition confirming de-aromatization and nucleophilic addition. Whereas no such peak shifting was observed in case of ascorbate ion addition confirming non-covalent addition of ascorbate.Theoretical insight into the selectivity and complexation behavior of ascorbate ion with quinoxaline moiety is gained through density functional theory (DFT) calculations. Moreover, the absorption properties of these complexes are modeled theoretically, and compared with the experimental data. In addition, thermal decomposition of sensor (1 and 2) has been studied by the means of differential scanning calorimetry (DSC), thermogravimetry (TG), and differential thermogravimetry (DTG) to signify their utility at variable temperature.

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Biochemistry of Inorganic Fluoride

Cited by 26 publications

References 128 publications

Self‐propagating amplification reactions for molecular detection and signal amplification: Advantages, pitfalls, and challenges

Self‐propagating amplification reactions for molecular detection and signal amplification: Advantages, pitfalls, and challenges

A Multifunctional Carbohydrazide‐Based Chromofluorescent Sensor for the Selective Detection of Cu(II) and Zn(II) Ion

Novel quinoxaline based chemosensors with selective dual mode of action: nucleophilic addition and host–guest type complex formation

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