Biochemistry of the Lanthanides

Evans, Christopher H.

doi:10.1007/978-1-4684-8748-0

Cited by 418 publications

(400 citation statements)

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“…It has been speculated that, at certain concentrations, GBCAs may elicit their potential toxic effects either through a direct loss of the Gd 3þ ion or through transmetallation-the exchange of Gd 3þ with endogenous ions (33,35,36)-and thereby deplete essential trace elements, such as Zn 2þ . Gd has a similar ion radius to calcium (Ca) (37), suggesting that the potential toxic effects of Gd 3þ , at certain concentrations, can be attributed to the replacement of Ca 2þ in various cellular processes (eg, ion channels) (37). To investigate the potential role of the release of Gd 3þ ions from GBCAs, the lanthanide has to be administered in a soluble form.…”

Section: Potential Role Of Gbcas In Nsfmentioning

confidence: 99%

“…Simple salts like GdCl 3 or Gd-acetate offer very low solubility under physiological conditions. Due to this rapid precipitation, GdCl 3 and Gd-acetate possess different pharmacokinetic and toxicological profiles compared with GBCAs (37). For example, injection of GdCl 3 leads to a depletion of macrophages from the bloodstream (38) and the preferential accumulation of Gd in the liver and spleen (11,16).…”

Section: Potential Role Of Gbcas In Nsfmentioning

confidence: 99%

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Gadolinium‐based contrast agents and NSF: Evidence from animal experience

Sieber

Steger‐Hartmann

Lengsfeld

et al. 2009

Magnetic Resonance Imaging

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Nephrogenic systemic fibrosis (NSF) is a potentially severe systemic disease typically characterized by fibrosis of the skin and connective tissues. The etiology of NSF is still unknown but is likely to be multifactorial. Specific triggers under scientific evaluation have included surgery and/or the occurrence of thrombosis or other vascular injury, proinflammatory state, the administration of high doses of erythropoietin, and more recently the use of gadolinium-based contrast agents (GBCAs). The aim of this review is to summarize knowledge regarding the pathogenesis of NSF and the potential role of GBCAs in its pathology, with a focus on animal experiments. The potential role of complex stability of GCBAs will be highlighted by results from several in vitro and in vivo experiments in rodent models of NSF.

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Section: Potential Role Of Gbcas In Nsfmentioning

confidence: 99%

Section: Potential Role Of Gbcas In Nsfmentioning

confidence: 99%

Gadolinium‐based contrast agents and NSF: Evidence from animal experience

Sieber

Steger‐Hartmann

Lengsfeld

et al. 2009

Magnetic Resonance Imaging

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“…Especially with the wide use of REE-salvolatile compound fertilizer and REE-phosphate fertilizer in recent years, approximately 50-100 million tons of REEs (based on REE-oxides) enter the agricultural system every year (Xiong et al 2001). Through bioaccumulation along the food chain, long-term and widely applied REE-based fertilizer may cause adverse health effects and potential detrimental environmental issues; therefore, environmental scientists are concerned with the use of REEs (Sabbioni et al 1982;Evans 1990;Lu et al 1995;Liu et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Environmental biogeochemical behaviors of rare earth elements in soil–plant systems

Liang

Zhang

Wang

et al. 2005

Environ Geochem Health

121

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With the continual increase in the utilization of rare earth elements (REEs) for industrial and agricultural purposes in China, the research into the environmental biogeochemical behavior of REEs has become a pressing issue. The REEs' content in soil and various parts of wheat under different conditions in soil-plant systems were measured by INAA and ICP-MS. The results showed four aspects. (1) The mean value of total REEs in soil of China was 176.8 mg kg )1 . The mean ratio of SLREE/SHREE in soils was 8.0 and cerium accounts for 42% of the total REEs. The content of REEs in wheat seed ranged between 10 )11 and 10 )8 g g )1 , 3-4 orders of magnitude lower than that in soil. (2) The REEs contents in ryegrass, especially in roots, were significantly related to that of soil. The bioavailability of REEs in soil mainly depended on the exchangeable fraction of REEs, which was strongly affected by the physico-chemical properties of the soil. (3) Long-term foliage-dressing with Changle microfertilizer of REEs did not affect the contents and distribution patterns of REEs in soil. At the maturing stage of spring wheat, the REEs content was in the order of root > leaf >stem and crust. Compared with the control, foliage-dressing has a higher accumulation of REEs in root and leaf. However, no significant difference was found in stem and crust between the two treatments. (4) There was no significant accumulation with the soil-dressing method. When comparing controls in both foliage-and soil-dressing methods, no distinct residue of REEs in grains was found.

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“…There is an increasing interest in the use of lanthanide in medicine and biology [4][5][6][7]. 169 Yb has been considered as a potential replacement for 125 I and 103 Pd.…”

Section: Discussionmentioning

confidence: 99%

“…169 Yb (c-emission, t ½ % 32 days) was reported to provide comparable tumor control and has been considered as a potential replacement for 125 I and 103 Pd in permanent implants [4,5]. Evidently, the intracellular accumulation is very important in these cases, but its mechanism still remains unclear.It was suggested that the particulate-and protein-bound Ln enters the cells by endocytosis [6]; the anionic lowmolecular-mass complexes, via anion channels [7], whereas free Ln 3+ is transported by ionophores [8], Na + /Ca 2+ exchange [9] and self-facilitated diffusion [10]. It is known that Ln 3+ is mainly bound to proteins in the extracellular media (e.g.…”

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confidence: 99%

Complexation of ytterbium to human transferrin and its uptake by K562 cells

Zhang

Liu

et al. 2002

European Journal of Biochemistry

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There is an increasing interest in the use of lanthanides in medicine. However, the mechanism of their accumulation in cells is not well understood. Lanthanide cations are similar to ferric ions with regard to transferrin binding, suggesting transferrin-receptor mediated transport is possible; however, this has not yet been confirmed. In order to clarify this mechanism, we investigated the binding of Yb 3+ to apotransferrin by UV-Vis spectroscopy and stopped-flow spectrophotometry, and found that Yb 3+ binds to apotransferrin at the specific iron sites in the presence of bicarbonate. The apparent binding constants of these sites showed that the affinity of Yb 3+ is lower than that of Fe 3+ and binding of Yb 3+ in the N-lobe is kinetically favored while the C-lobe is thermodynamically favored. The first Yb 3+ bound to the C-lobe quantitatively with a Yb/ apotransferrin molar ratio of < 1, whereas the binding to the other site is weaker and approaches completeness by a higher molar ratio only. As demonstrated by 1 H NMR spectra, Yb 3+ binding disturbed the conformation of apotransferrin in a manner similar to Fe 3+ . Flow cytometric studies on the uptake of fluorescein isothiocyanate labeled Yb 3+ -bound transferrin species by K562 cells showed that they bind to the cell receptors. Laser scanning confocal microscopic studies with fluorescein isothiocyanate labeled Yb 3+ -bound transferrin and propidium iodide labeled DNA and RNA in cells indicated that the Yb 3+ entered the cells. The Yb 3+ -transferrin complex inhibited the uptake of the fluorescein labeled ferric-saturated transferrin (Fe 2 -transferrin) complex into K562 cells. The results demonstrate that the complex of Yb 3+ -transferrin complex was recognized by the transferrin receptor and that the transferrin-receptor-mediated mechanism is a possible pathway for Yb 3+ accumulation in cells.Keywords: K562 cells; recognition; transferrin; ytterbium.Lanthanides have been suggested for the treatment of a series of diseases and for diagnosis by magnetic resonance imaging [1,2]. Recent studies also show that they could act as scavengers of free radicals [3] and therefore protect cells and tissues from oxidative stress-induced injury. Some lanthanides nuclides were also suggested for palliative therapy. 169 Yb (c-emission, t ½ % 32 days) was reported to provide comparable tumor control and has been considered as a potential replacement for 125 I and 103 Pd in permanent implants [4,5]. Evidently, the intracellular accumulation is very important in these cases, but its mechanism still remains unclear.It was suggested that the particulate-and protein-bound Ln enters the cells by endocytosis [6]; the anionic lowmolecular-mass complexes, via anion channels [7], whereas free Ln 3+ is transported by ionophores [8], Na + /Ca 2+ exchange [9] and self-facilitated diffusion [10]. It is known that Ln 3+ is mainly bound to proteins in the extracellular media (e.g. plasma). Various studies have demonstrated that considerable amounts of Ln are bound to the iron transport prote...

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Biochemistry of the Lanthanides

Cited by 418 publications

References 0 publications

Gadolinium‐based contrast agents and NSF: Evidence from animal experience

Gadolinium‐based contrast agents and NSF: Evidence from animal experience

Environmental biogeochemical behaviors of rare earth elements in soil–plant systems

Complexation of ytterbium to human transferrin and its uptake by K562 cells

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