Biochemistry, Safety, Pharmacological Activities, and Clinical Applications of Turmeric: A Mechanistic Review

Ahmad, Rabia; Hussain, Muhammad Bilal; Sultan, Muhammad Tauseef; Arshad, Muhammad Sajid; Waheed, Marwa; Shariati, Mohammad Ali; Plygun, Sergey; Hashempur, Mohammad Hashem

doi:10.1155/2020/7656919

Cited by 106 publications

(99 citation statements)

References 128 publications

(122 reference statements)

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“…Interestingly, the study comes up with clear evidence for the rapid onset of the niosomal emulgel formulation. Our results came in accordance with a recent study that proved the significant decline in percentage of inflammation in animals treated with curcumin loaded nanoemulgel compared with nontreated animals and placebo group [ 1 , 31 ].…”

Section: Resultssupporting

confidence: 93%

“…Diferuloylmethane or curcumin is obtained from turmeric, which is the powdered root of Curcuma longa . Curcumin possesses a wide spectrum of pharmacological effects, because of its inhibitory effects on some metabolic enzymes [ 1 ]. It inhibits cyclooxygenases (COXII) enzymes involved in inflammation via blocking the formation of reactive-oxygen species, which result in anti-inflammatory properties [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Curcumin Niosomes Prepared from Proniosomal Gels: In Vitro Skin Permeability, Kinetic and In Vivo Studies

2021

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Curcumin is a poorly water-soluble drug that is used for the treatment of inflammations, tumors, wound healing antioxidant and other diseases. In the current manuscript, it is successfully formulated into proniosome gels. The proniosomes are readily hydrated into niosomal formulations using warm water. Proniosomes were prepared using nonionic surfactants (tween 80, span 60) either solely or in combinations with cholesterol. The produced niosomal formulations were homogenous in size with vesicular sizes >343 and <1800 nm. The encapsulation efficiency percentage “EE%” of curcumin in niosomal formulations was different according to niosomal composition. It increased up to 99.74% in formulations of tween 80/Chol of 200 μmole/mL lipid concentration. Span 60/chol niosomes showed decreased curcumin EE%. Niosomal formulations showed increased SSTF and PC with enhancement ratios of more than 20-fold compared with curcumin suspension form. Kinetically, niosomes fitted to the Korsemeyer-Peppas model with non-Fickian transport according to their calculated n-values where curcumin suspension form showed Korsemeyer-Peppas kinetics with Fickian transport. Niosomal formulations deposited higher curcumin amounts in the skin compared with the suspension form. The best niosomal formulation (F9) was used for niosomal gel and emulgel fabrication. Finally, the anti-inflammatory activity of curcumin in various formulations was evaluated using a rat hind paw edema method and the % of swelling was 17.5% following 24 h in group treated with curcumin niosomal emulgel. In conclusion, this study suggests that the developed niosomal emulgel could significantly enhance the anti-inflammatory effect of curcumin and be an efficient carrier for the transdermal delivery of the drug.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Curcumin Niosomes Prepared from Proniosomal Gels: In Vitro Skin Permeability, Kinetic and In Vivo Studies

2021

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“…The plant species has been traditionally used to treat many infections. In addition, it has been documented to have a wide spectrum of pharmacological effects, including anti-oxidant ( Tanvir et al, 2017 ), anti-inflammatory ( Lee et al, 2020 ), and anti-cancer ( Ahmad et al, 2020 ) activities. The rhizome of C. longa is the most commonly used part for the medicinal purposes.…”

Section: Introductionmentioning

confidence: 99%

Curcuma longa rhizome extract and Curcumin reduce the adhesion of Acanthamoeba triangularis trophozoites and cysts in polystyrene plastic surface and contact lens

Mitsuwan

Sangkanu

Romyasamit

et al. 2020

International Journal for Parasitology: Drugs and Drug Resistan

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Curcuma longa and Curcumin have been documented to have a wide spectrum of pharmacological effects, including anti- Acanthamoeba activity. Hence, this study sought to explore the anti-adhesion activity of C. longa extract and Curcumin against Acanthamoeba triangularis trophozoites and cysts in plastic and contact lenses. Our results showed that C. longa extract and Curcumin significantly inhibited the adhesion of A. triangularis trophozoites and cysts to the plastic surface, as investigated by the crystal violet assay (P < 0.05). Also, an 80–90% decrease in adhesion of trophozoites and cysts to the plastic surface was detected following the treatment with C. longa extract and Curcumin at 1/2 × MIC, compared to the control. In the contact lens model, approximately 1 log cells/mL of the trophozoites and cysts was reduced when the cells were treated with Curcumin, when compared to the control. Pre-treatment of the plastic surface with Curcumin at 1/2-MIC reduced 60% and 90% of the adhesion of trophozoites and cysts, respectively. The reduction in 1 Log cells/mL of the adhesion of A. triangularis trophozoites was observed when lenses were pre-treated with both the extract and Curcumin. Base on the results obtained from this study, A. triangularis trophozoites treated with C. longa extract and Curcumin have lost strong acanthopodia, thorn-like projection pseudopodia observed by scanning electron microscope. This study also revealed the therapeutic potentials of C. longa extract and Curcumin, as such, have promising anti-adhesive potential that can be used in the management/prevention of A. triangularis adhesion to contact lenses.

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“…Languatis rhizome mengandung bahan aktif etilsinamat dan quercetin sebagai antiinflamasi, antioksidan, antikanker dan antiaging (Amagai et al, 2017;Ahlina et al, 2020). Curcuma sp mengandung kurkuminoid dan minyak esensial (Vaughn et al, 2016;Ololade et al, 2020), sebagai antiseptik, analgesik, antijamur dan antiinflamasi (Shan et al, 2018;Ahmad et al, 2020). Imperatae rhizome mengandung alkaloid, flavonoid, fenolik, triterpennoid, glikosida tannin, saponin dan steroid sebagai antiinflamasi dan antiplatelet (Liu et al, 2010;Anggraeni et al, 2019).…”

Section: Pengamatan Makroskopisunclassified

Penilaian Potensi Toksisitas Akut Dermal Obat Hewan Alami Minyak Rajas pada Tikus Wistar

Merdana¹,

Azizati²,

Arjana³

et al. 2020

bulvet

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Pengujian toksisitas terhadap suatu produk atau obat baru yang akan beredar dipasaran lazim dilakukan untuk mengetahui efikasi dan keamanannya. Penelitian ini bertujuan untuk menilai potensi toksisitas akut dermal obat hewan alami minyak rajas pada tikus wistar betina. Metode uji yang digunakan merujuk protokol Organization for Economic Co-operation and Development nomor tes 402 tahun 2017. Hasil uji diperoleh indeks iritasi primer sebesar nol, dan median lethal dose akut dermal >2000 mg/kgbb. Hal ini dapat disimpulkan bahwa minyak rajas tidak menimbulkan toksisitas akut dermal secara topikal dan aman untuk digunakan.

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Biochemistry, Safety, Pharmacological Activities, and Clinical Applications of Turmeric: A Mechanistic Review

Cited by 106 publications

References 128 publications

Curcumin Niosomes Prepared from Proniosomal Gels: In Vitro Skin Permeability, Kinetic and In Vivo Studies

Curcumin Niosomes Prepared from Proniosomal Gels: In Vitro Skin Permeability, Kinetic and In Vivo Studies

Curcuma longa rhizome extract and Curcumin reduce the adhesion of Acanthamoeba triangularis trophozoites and cysts in polystyrene plastic surface and contact lens

Penilaian Potensi Toksisitas Akut Dermal Obat Hewan Alami Minyak Rajas pada Tikus Wistar

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