Biochemoprevention for Dysplastic Lesions of the Upper Aerodigestive Tract

Papadimitrakopoulou, Vali A.

doi:10.1001/archotol.125.10.1083

Cited by 94 publications

(81 citation statements)

References 25 publications

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“…Many of these studies resulted in some degree of clinical success (6,7,(20)(21)(22)(23)(24). Critical evaluation of the clinical trials data, however, provides a strong rationale to evaluate other chemopreventive compounds.…”

Section: Discussionmentioning

confidence: 99%

“…Oropharyngeal cancer annually affects approximately 29,370 persons in the U.S., and more than 7,200 Americans die each year from this disease (1). Despite concerted efforts to improve treatments, 5 year survival rates for patients with advanced stage oral squamous cell carcinoma (oral SCC) remain among the lowest of solid cancers.…”

Section: Introductionmentioning

confidence: 99%

“…Although pharyngeal premalignant lesions often respond to chemoprevention therapy, oral cavity lesions were frequently unresponsive, even to combination agents such as a cis-retinoic acid, IFN-α, and α-tocopherol cocktail (6). Some agents such as vitamin A derivatives were partially effective in managing oral premalignant lesions, but these formulations often caused toxicities such as severe mucositis (7). Recently, a protocol that used an attenuated adenovirus (ONYX-015) containing mouthwash to target p53 defective cells induced a 37% transient resolution of epithelial dysplasia (8).…”

Section: Introductionmentioning

confidence: 99%

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Formulation and In-Vitro and In-Vivo Evaluation of a Mucoadhesive Gel Containing Freeze Dried Black Raspberries: Implications for Oral Cancer Chemoprevention

et al. 2007

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Purpose-The purpose of these studies was to formulate mucoadhesive gels containing freeze dried black raspberries (FBR) and to determine optimum parameters for a subset of FBR bioactive compounds including anthocyanin stability, absorption and penetration in-vitro and in-vivo.Materials and Methods-Berry gels were prepared having FBR at 5% and 10% w/w and final pHs ranging from 3.5 to 7.5. A HPLC assay was developed to quantify and determine the stability of the anthocyanins in the gels. A single time-point study was performed to determine anthocyanin uptake when the gels were applied to oral mucosa. Penetration of anthocyanins into human oral tissue explants was determined as a function of gel pH and FBR content. A HPLC-mass spectroscopy assay was utilized to quantify the anthocyanin levels in human oral tissue explants, saliva, and blood.Results-The stability of anthocyanins in the gel was directly related to gel pH and storage temperature. Maximum stability of anthocyanins was found at lower pH (pH 3.5) and storage temperature (4°C). Anthocyanins contained in mucoadhesive berry gel formulations were readily absorbed into human oral mucosa tissue as evidenced by detectable blood levels within 5 min after gel application. There was a trend for greater penetration of anthocyanins into tissue explants for berry gels with a final pH of 6.5 versus pH 3.5.Conclusions-Formulation and characterization of a novel gel formulation for local delivery of chemopreventive compounds to human oral mucosal tissues has been described. The results show anthocyanin stability was dependent upon gel pH and storage temperature and also demonstrate that the gel composition is well-suited for absorption and penetration into the target oral mucosal tissue site.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Formulation and In-Vitro and In-Vivo Evaluation of a Mucoadhesive Gel Containing Freeze Dried Black Raspberries: Implications for Oral Cancer Chemoprevention

et al. 2007

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“…59 However, in a recent study using combinatorial treatment with 13-cis retinoic acid, interferon-α, and α-tocopherol in laryngeal dysplasia, histological response was not accompanied by reversal of the underlying genetic aberrations. 60 In clinically relevant doses, retinoids have tangible side effects, most notably mucocutaneous reactions, headache, xerophthalmia, and adverse alterations in lipid profiles.…”

Section: R E T R a C T E Dmentioning

confidence: 97%

Novel Management of Oral Cancer: A Paradigm of Predictive Oncology

Sudbø¹

2004

Clinical Medicine & Research

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The rationale for molecular-targeted prevention of oral cancer is strong. Oral cancer is a major global threat to public health with 300,000 new cases diagnosed worldwide on an annual basis. Notably, the great morbidity and mortality rates of this devastating disease have not improved in decades. Oral cancer development is a tobacco-related multistep and multifocal process involving field carcinogenesis and intraepithelial clonal spread. Biomarkers of genomic instability, such as aneuploidy and allelic imbalance, can accurately measure the cancer risk of oral premalignant lesions or intraepithelial neoplasia (IEN). Retinoid-oral IEN studies (e.g., retinoid acid receptor-β, p53, genetic instability, loss of heterozygosity, and cyclin D1) have advanced the overall understanding of the biology of intraepithelial carcinogenesis and preventive agent molecular mechanisms and targets, important advances for monitoring preventive interventions, assessing cancer risk, and pharmacogenomics. Clinical management of oral IEN varies from watchful waiting to complete resection, although complete resection does not prevent oral cancer in high-risk patients. New approaches, such as interventions with molecular-targeted agents and agent combinations in molecularly defined high-risk oral IEN patients, are urgently needed to reduce the devastating worldwide consequences of oral cancer.

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“…Other chemopreventive agents that have shown preventive effects include selenium and vitamin E. Recently, Papadimitrakopoulou et al (12) reported that a combination of 13-cRA, vitamin E, and IFN-a restored advanced laryngeal premalignant lesions. Shin et al (13,14) showed that the same combination suppressed the development of second primary tumor and/or recurrence, and achieved an excellent survival rate in stage III/IV HNSCC, making this a promising combination chemopreventive approach.…”

Section: Chemoprevention For Hncmentioning

confidence: 99%

Interaction between epidermal growth factor receptor– and cyclooxygenase 2–mediated pathways and its implications for the chemoprevention of head and neck cancer

Choe

Zhang

Shin

et al. 2005

Molecular Cancer Therapeutics

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Head and neck squamous cell carcinoma is a well-known model for chemoprevention studies because of its field cancerization effect, its multistep carcinogenesis process, and the easy accessibility of biopsies to target lesions. With new understandings of head and neck carcinogenesis and the development of molecular targeted therapy, chemoprevention trials for head and neck squamous cell carcinoma have been rapidly updated. Cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors are gaining significant attention as potential chemopreventive agents. Both COX-2 and EGFR are involved in head and neck carcinogenesis. Targeting COX-2 and EGFR separately has shown promising antitumor activity. Recently, combinations of COX-2 and EGFR tyrosine kinase inhibitors have been reported to show synergistic/ additive effects in preclinical studies. Because COX-2 and EGFR tyrosine kinase inhibitors are toxic as single agents in clinical trials, the combination of COX-2 and EGFR tyrosine kinase inhibitors used at lower doses seems more promising than monotherapy with either as a novel strategy in head and neck cancer chemoprevention. [Mol Cancer Ther 2005;4(9):1448 -55]

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Biochemoprevention for Dysplastic Lesions of the Upper Aerodigestive Tract

Abstract: Biochemoprevention is a promising biologic approach for laryngeal dysplasia and needs to be investigated further.

Cited by 94 publications

References 25 publications

Formulation and In-Vitro and In-Vivo Evaluation of a Mucoadhesive Gel Containing Freeze Dried Black Raspberries: Implications for Oral Cancer Chemoprevention

Formulation and In-Vitro and In-Vivo Evaluation of a Mucoadhesive Gel Containing Freeze Dried Black Raspberries: Implications for Oral Cancer Chemoprevention

Novel Management of Oral Cancer: A Paradigm of Predictive Oncology

Interaction between epidermal growth factor receptor– and cyclooxygenase 2–mediated pathways and its implications for the chemoprevention of head and neck cancer

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