Biocidal Activity of Nanocrystalline Silver Powders and Particles

Smetana, Alexander B.; Klabunde, Kenneth J.; Marchin, George R.; Sorensen, C. M.

doi:10.1021/la800091y

Cited by 197 publications

(109 citation statements)

References 17 publications

Supporting

Mentioning

103

Contrasting

Unclassified

Order By: Relevance

“…It has also been reported that Ag-NPs dissolve and generate silver ions, resulting in disruption of ATP production, DNA replication, and ROS generation under certain cellular condition 19,21) . Surface capping of nanoparticles prevented silver ion release, leading to decreased cytotoxicity for cells and organs 22,23) . Therefore, this modification can enhance stability and improve the biocompatibility of these materials 19) .…”

Section: Discussionmentioning

confidence: 99%

Micromorphological cellular responses of MC3T3-E1 and RAW264.7 after exposure to water-dispersible silver nanoparticles stabilized by metal-carbon σ-bonds

et al. 2013

View full text Add to dashboard Cite

With the continuous progress in nanomaterial development for biomedicine, the potential cytotoxicity of nanoparticles is drawing more attention and concern for clinical applications. The purpose of this study was to evaluate biological responses of new waterdispersible silver nanoparticles (Ag-NPs) stabilized by Ag-C σ-bonds in cultured murine macrophages (RAW264.7) and osteoblastlike cells (MC3T3-E1) using cell viability and morphological analyses. For RAW264.7, Ag-NPs seemed to induce cytotoxicity that was dependent on the Ag-NP concentration. However, no cytotoxic effects were observed in the MC3T3-E1 cell line. In microscopic analysis, Ag-NPs were taken up by MC3T3-E1 cells with only minor cell morphological changes, in contrast to RAW264.7 cells, in which particles aggregated in the cytoplasm and vesicles. The ability of endocytosis of macrophages may induce harmful effects due to expansion of cell vesicles compared to osteoblast-like cells with their lower uptake of Ag-NPs.

show abstract

Section: Discussionmentioning

confidence: 99%

Micromorphological cellular responses of MC3T3-E1 and RAW264.7 after exposure to water-dispersible silver nanoparticles stabilized by metal-carbon σ-bonds

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Previous reports stated that, the silver nanoparticles have potential antibacterial property against E. coli, S. aureus, Staphylococcus epidermis, Leuconostoc mesenteroides, Bacillus subtilis, Klebsiella mobilis and K. pneumonia (Benn and Westerhoff 2008;Chen and Chiang 2008;Falletta et al 2008;Hernandez-Sierra et al 2008;Ingle et al 2008;Jung et al 2009;Kim 2007;Kim et al 2007Kim et al , 2009Kvitek et al 2008;Raffi et al 2008;Ruparelia et al 2008;Smetana et al 2008;Sondi and Salopek-Sondi 2004;Vertelov et al 2008;Yang et al 2009;Yoon et al 2008a, b). It has been shown that silver nanoparticles prepared with a variety of synthetic methods have effective antimicrobial activity (Lok et al 2006;Baker et al 2005;Aymonier et al 2002;Melaiye et al 2005;Sondi and Salopek-Sondi 2004;Kim et al 2008;Lee et al 2008;Alt et al 2004).…”

Section: Proteus Morganii Staphylococcus Aureusmentioning

confidence: 99%

Antibacterial potential of silver nanoparticles against isolated urinary tract infectious bacterial pathogens

2011

View full text Add to dashboard Cite

The silver nanoparticles were synthesized by chemical reduction method and the nanoparticles were characterized using ultraviolet-visible (UV-Vis) absorption spectroscopy and X-ray diffraction (XRD) studies. The synthesized silver nanoparticles were investigated to evaluate the antibacterial activity against urinary tract infectious (UTIs) bacterial pathogens. Thirty-two bacteria were isolated from mid urine samples of 25 male and 25 female patients from Thondi, Ramanathapuram District, Tamil Nadu, India and identified by conventional methods. Escherichia coli was predominant (47%) followed by Pseudomonas aeruginosa (22%), Klebsiella pneumoniae (19%), Enterobacter sp. (6%), Proteus morganii (3%) and Staphylococcus aureus (3%). The antibacterial activity of silver nanoparticles was evaluated by disc diffusion assay. P. aeruginosa showed maximum sensitivity (11 ± 0.58 mm) followed by Enterobacter sp. (8 ± 0.49 mm) at a concentration of 20 lg disc -1 and the sensitivity was highly comparable with the positive control kanamycin and tetracycline. K. pneumoniae, E. coli, P. morganii and S. aureus showed no sensitivity against all the tested concentrations of silver nanoparticles. The results provided evidence that, the silver nanoparticles might indeed be the potential sources to treat urinary tract infections caused by P. aeruginosa and Enterobacter sp.

show abstract

“…Among these composites, TiO 2 /Ag composites are more potent antibacterial agents due to the fact that Ag nanoparticles (Ag NPs) deposited in TiO 2 matrix act as a conductor and charge separators for blocking electron-hole recombination, resulting in maximizing the production of ROS [15][16][17] . Furthermore, Ag NPs have been known as effective antimicrobial agents with broad-spectrum antibacterial activity, good durability, heat resistance and stability [18,19] . Recently, TiO 2 /Ag composites with different morphologies were prepared by a range of various methods, including UV-irradiation, [16] solvothermal, [20] sol-gel, [21] and chemical deposition [22] .…”

Section: Introductionmentioning

confidence: 99%

Highly synergistic antimicrobial activity of spherical and flower-like hierarchical titanium dioxide/silver composites

Cheng

et al. 2017

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

ABSTRACT:A spherical titanium dioxide/silver (TiO 2 /Ag) composite and a flower-like hierarchical TiO 2 /Ag composite were prepared via a template-induced method and a solvothermal method based on the Ag/Carbon spheres templates followed by calcination treatment, respectively. The morphologies of the composites were controlled by changing the concentration of reactants and calcination temperature. The antibacterial efficiency of the composites was evaluated with both Gram-negative Escherichia coli and 2 species (ROS) and silver ions were observed, which lead to superior antibacterial activities of these TiO 2 /Ag composites with a bacteriostatic rate as high as 99% even in the absence of light. The morphological effect of the composites on the antibacterial efficacy was also investigated. In addition, a durable antimicrobial coating was also fabricated by incorporating the hierarchical TiO 2 /Ag composite into a commercial emulsion solution of polyvinyl acetate, which exhibited a promising application in bacterial sensitive locations.

show abstract

Biocidal Activity of Nanocrystalline Silver Powders and Particles

Abstract: While the activity of the SMAD powders is lower than that of pure silver nitrate, it has the ability to kill bacteria very effectively and over long periods of time.

Cited by 197 publications

References 17 publications

Micromorphological cellular responses of MC3T3-E1 and RAW264.7 after exposure to water-dispersible silver nanoparticles stabilized by metal-carbon σ-bonds

Micromorphological cellular responses of MC3T3-E1 and RAW264.7 after exposure to water-dispersible silver nanoparticles stabilized by metal-carbon σ-bonds

Antibacterial potential of silver nanoparticles against isolated urinary tract infectious bacterial pathogens

Highly synergistic antimicrobial activity of spherical and flower-like hierarchical titanium dioxide/silver composites

Contact Info

Product

Resources

About