Biocidal Efficacy of a Hydrogen Peroxide Lens Care Solution Incorporating a Novel Wetting Agent

Gabriel, Manal M.; McAnally, Cindy; Bartell, John; Walters, Rhonda; Clark, Linda; Crary, Monica; Shannon, Stephen Paul

doi:10.1097/icl.0000000000000549

Cited by 14 publications

(13 citation statements)

References 17 publications

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“…To date, there are many studies on the antibiotic effect of hydrogen peroxide against microorganisms attached to SCLs. [1][2][3][4][5][6][7] For example, hydrogen peroxide was effective against clinical bacterial isolates and not affected by organic soils in tears. Retuerto and associates examined microbiome adherent to CLs and the association of bacterial communities with the use of lens care solutions.…”

Section: Discussionmentioning

confidence: 99%

“…Hydrogen peroxide has been reported to be superior to MPS in disinfecting and cleaning effects. [1][2][3][4][5] It has also been reported that microorganisms such as bacteria, viruses, fungi, and Acanthamoeba attached to SCLs are killed by soaking with 3% hydrogen peroxide for 6 hours. 6 However, the cleaning effect of hydrogen peroxide on pollens attached to SCLs is not well understood.…”

Section: Introductionmentioning

confidence: 99%

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<p>Is Hydrogen Peroxide Disinfection Effective for Cleaning Pollen Particles Attached to Contact Lenses?</p>

Sunaga

Mimura

Matsuoka

et al. 2020

OPTO

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Purpose It has been proven that wearing soft contact lenses (SCLs) can make pollen-induced allergic conjunctivitis worse. We investigated the cleaning effect of disinfectants and rinsing solution on cedar pollen attached to SCLs. Methods Two-week replacement disposable SCLs, to which pollen particles were experimentally attached, were washed and cleaned with either saline of rinsing solution (n = 10) or 3% hydrogen peroxide (n = 10). We observed, under a microscope, the cedar pollen adhered to the SCLs after washing. Results The number of residual pollens attached to SCLs was 23.7 ± 25.7 with rinsing solution and 0.2 ± 0.6 with 3% hydrogen peroxide solution per single area (100 µm × 100 µm). The percentage of adhesion area of pollen to the SCLs was 0.9 ± 1.1% with rinsing solution and 0.0 ± 0.0% with 3% hydrogen peroxide solution. There were significant differences in the number of pollen and adhesion areas of pollen between the two groups (p < 0.05 and p < 0.05, respectively). Conclusion These results suggest that hydrogen peroxide solution is superior in cleaning effect of cedar pollen attached to SCLs compared to saline.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Is Hydrogen Peroxide Disinfection Effective for Cleaning Pollen Particles Attached to Contact Lenses?</p>

Sunaga

Mimura

Matsuoka

et al. 2020

OPTO

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“…Gabriel et al 7,8 reported on the antimicrobial efficacy of CCP in the Stand-alone and Regimen tests. Solutions in CCP lens cases with neutralizing discs were inoculated with organisms and evaluated for microbial loads at DT.…”

Section: Antimicrobial Efficacymentioning

confidence: 99%

“…The antimicrobial efficacy of a disinfecting solution can be further challenged using clinically relevant ocular strains isolated from patients with adverse events (AEs), as these strains may be more resistant to disinfection than laboratory strains. Gabriel et al 7 tested CCP against two clinically relevant ocular isolates from infections of P. aeruginosa and one strain each of Stenotrophomonas maltophilia and S. aureus. CCP reduced all clinically relevant bacterial strains by >4.5 logs, therefore exceeding the ISO 3-log reduction requirement for bacteria ( Figure 2).…”

Section: Antimicrobial Efficacymentioning

confidence: 99%

“…Strains belonging to the T4 genotype are most commonly associated with Acanthamoeba keratitis. 7 While there are no standards for determining lens care solution efficacy against Acanthamoeba spp, Figure 3 shows that CCP reduces trophozoites by ≥4.0 logs (99.99%) and cysts by >2.0 logs (99%) at DT. The superior efficacy of the CCP hydrogen peroxide lens care system compared with multipurpose solutions (MPS) against Acanthamoeba spp is supported by previous studies.…”

Section: Antimicrobial Efficacymentioning

confidence: 99%

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Hydrogen Peroxide Disinfecting Solution for Gas Permeable Contact Lenses: A Review of the Antimicrobial Efficacy, Compatibility, and Safety Performance of a One-Step Lens Care System

Gabriel

McAnally

Chen

et al. 2021

OPTO

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CLEAR CARE PLUS (CCP), also known as AOSEPT PLUS with HydraGlyde, is approved for use with gas permeable (GP) lenses, and the indication is supported by the scientific evidence that is reviewed in this article. Antimicrobial efficacy testing of CCP both as a stand-alone disinfectant and as part of a regimen shows that CCP exceeds the ISO 14729 criteria against bacteria, yeast, and mold. In real-world conditions, it is effective against clinically relevant bacterial strains isolated from adverse events and against the two forms, trophozoites and cysts, of resilient Acanthamoeba species. Compatibility tests of CCP with two types of GP lenses indicate that the physical and/or optical parameters of lenses are unaffected through 30 cycles of simulated use with CCP, and a clinical trial shows substantial equivalence of clinical performance with a commonly used GP multipurpose solution. These results indicate that CCP is well suited for cleaning and disinfection of GP contact lenses.

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Modelling and optimization of the ferrous to ferric sulphate conversion with hydrogen peroxide using polynomial‐PSO and PSO‐ANNs models

et al. 2022

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In this present work, polynomial and artificial neural networks models, adjusted by particle swarm optimization, were implemented in an attempt to improve process modelling and to achieve reliable reaction representation behaviour. Parameter optimization of the conversion reaction of ferrous to ferric sulphate in concentrated solutions using hydrogen peroxide as an oxidant is a process of interest due to the importance of producing this ferric salt, a widely used coagulant/flocculant in water treatment, as a chlorine‐free product. Previous work reported a process optimization attempt based on a factorial design of experiments. The obtained polynomial model based on least‐squares showed a minimally satisfactory R2 of 0.7481. The comparison of the obtained models' performance showed a significant improvement in the prediction of experimental conditions. The results indicated that artificial neural networks‐based models presented a higher predictive capability for highly non‐linear experimental data, and the best model achieved an R2 of 0.9744 for the conversion prediction. Optimal ranges for cost‐effective process conditions were investigated through the refined response surface charts obtained.

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Biocidal Efficacy of a Hydrogen Peroxide Lens Care Solution Incorporating a Novel Wetting Agent

Abstract: Both solutions eliminated or reduced populations of FDA/ISO compendial bacteria and fungi as well as clinically relevant microorganisms and Acanthamoeba trophozoites and cysts. The addition of EOBO-21 to the 3% H2O2 lens care solution had no impact on antimicrobial activity.

Cited by 14 publications

References 17 publications

<p>Is Hydrogen Peroxide Disinfection Effective for Cleaning Pollen Particles Attached to Contact Lenses?</p>

<p>Is Hydrogen Peroxide Disinfection Effective for Cleaning Pollen Particles Attached to Contact Lenses?</p>

Hydrogen Peroxide Disinfecting Solution for Gas Permeable Contact Lenses: A Review of the Antimicrobial Efficacy, Compatibility, and Safety Performance of a One-Step Lens Care System

Modelling and optimization of the ferrous to ferric sulphate conversion with hydrogen peroxide using polynomial‐PSO and PSO‐ANNs models

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