Biocidal spray product exposure: Measured gas, particle, and surface concentrations compared with spray model simulations

Clausen, Per Axel; Mørck, Thit Aarøe; Jensen, Alexander C. Ø.; Schou, Torben Wilde; Kofoed‐Sørensen, Vivi; Koponen, Ismo K.; Frederiksen, Marie; Detmer, Ann; Fink, Michael; Nørgaard, Asger W.; Wolkoff, Peder

doi:10.1080/15459624.2019.1689247

Cited by 13 publications

(15 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several methods have been applied to assess indoor exposure to pyrethroids, including indoor air monitoring, biomonitoring, and mathematical modeling for the indoor environment and a human body. For example, measured pyrethroid concentrations in indoor air samples were used to estimate external exposure to pyrethroids 13–16 . However, measured air concentrations were often significantly lower than those estimated from mathematical models 15,16 .…”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15][16] However, measured air concentrations were often significantly lower than those estimated from mathematical models. 15,16 Because pyrethroids have relatively high octanolwater partition constants and low vapor pressure, 17,18 they tend to deposit on floors and partition to dust particles 19,20 and other indoor surfaces such as furniture or wallpapers. 13,14 Thus, significant loss of pyrethroids via deposition and sorption after application could explain this observed difference.…”

mentioning

confidence: 97%

“…13,14 Thus, significant loss of pyrethroids via deposition and sorption after application could explain this observed difference. 15,16 Comparative studies of air monitoring and biomonitoring reported limited correlation between external and internal exposures. 21 Physiologically based pharmacokinetic (PBPK) models have also been used to estimate internal exposure to pyrethroids.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Filling gaps between exposure modeling and the analysis of urinary biomarkers using personal air monitoring: An intervention study of permethrin used in home insecticide spray

et al. 2022

View full text Add to dashboard Cite

Permethrin is one of the most widely used active ingredients in spray-type home insecticides. However, indoor permethrin exposure resulting from the use of home insecticides is not well-characterized, as measured permethrin concentrations in indoor environmental and biological media with a known application rate are scarce.We conducted an intervention study with four participants for seven days. We conducted personal air monitoring and collected 24-h urine samples in which we quantified time-weighted average (TWA) permethrin concentrations in indoor air (C air ) and urinary concentrations of two permethrin metabolites, 3-phenoxybenzoic acid (3-PBA) and cis/trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (cis/trans-DCCA). We also estimated (1) TWA C air using a simple indoor air model and(2) urinary excreted (UE) mass using a simple excretion model with both estimated and measured TWA C air . Measurements of TWA C air from personal air monitoring were lower than those estimated from the indoor model by a factor of 2.9 to 49.4. The ratio of estimated to measured UE mass ranged 3.5-18.2 when using estimated TWA C air and 1.1-2.9 when using measured TWA C air . Smaller ratios in estimating internal permethrin exposure from personal air monitoring suggest that personal air monitoring could reduce uncertainties in permethrin exposure assessment resulting from the use of spray-type insecticides.

show abstract

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 97%

mentioning

confidence: 99%

See 1 more Smart Citation

Filling gaps between exposure modeling and the analysis of urinary biomarkers using personal air monitoring: An intervention study of permethrin used in home insecticide spray

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Volatile organic compounds (VOCs) are commonly used in consumer spray products for various purposes, such as personal care and biocides [ 1 , 2 , 3 ]. Estimating the exposure to VOCs is important for their safe use, and some VOCs in products are known to be harmful when inhaled.…”

Section: Introductionmentioning

confidence: 99%

“…Exposure assessment of these products has been requested by several regulatory authorities for the product’s evaluation and authorization [ 8 ]. As the chemical analysis of active ingredients for the exposure assessment can only be conducted for certain cases due to time and cost, mathematical modeling is commonly employed for VOCs in such products [ 3 , 9 ]. Models for the exposure assessment are divided into two parts: physical models for estimating the chemical concentration and exposure models for simulating the activity of a person [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Spatial Uncertainty in Modeling Inhalation Exposure to Volatile Organic Compounds in Response to the Application of Consumer Spray Products

Jung

Kim

Seol

et al. 2021

IJERPH

View full text Add to dashboard Cite

(1) Background: Mathematical exposure modeling of volatile organic compounds (VOCs) in consumer spray products mostly assumes instantaneous mixing in a room. This well-mixed assumption may result in the uncertainty of exposure estimation in terms of spatial resolution. As the inhalation exposure to chemicals from consumer spray products may depend on the spatial heterogeneity, the degree of uncertainty of a well-mixed assumption should be evaluated under specific exposure scenarios. (2) Methods: A room for simulation was divided into eight compartments to simulate inhalation exposure to an ethanol trigger and a propellant product. Real-time measurements of the atmospheric concentration in a room-sized chamber by proton transfer reaction mass spectrometry were compared with mathematical modeling to evaluate the non-homogeneous distribution of chemicals after their application. (3) Results: The well-mixed model overestimated short-term exposure, particularly under the trigger spray scenario. The uncertainty regarding the different chemical proportions in the trigger did not significantly vary in this study. (4) Conclusions: Inhalation exposure to aerosol generating sprays should consider the spatial uncertainty in terms of the estimation of short-term exposure.

show abstract

Comparison between estimation and measurement of inhalation exposure to active substances for disinfection workers

Kim,

Min,

Shin

et al. 2023

Atmospheric Pollution Research

View full text Add to dashboard Cite

Biocidal spray product exposure: Measured gas, particle, and surface concentrations compared with spray model simulations

Cited by 13 publications

References 21 publications

Filling gaps between exposure modeling and the analysis of urinary biomarkers using personal air monitoring: An intervention study of permethrin used in home insecticide spray

Filling gaps between exposure modeling and the analysis of urinary biomarkers using personal air monitoring: An intervention study of permethrin used in home insecticide spray

Spatial Uncertainty in Modeling Inhalation Exposure to Volatile Organic Compounds in Response to the Application of Consumer Spray Products

Comparison between estimation and measurement of inhalation exposure to active substances for disinfection workers

Contact Info

Product

Resources

About