Biocides and antibiotics with apparently similar actions on bacteria: is there the potential for cross-resistance?

Ng, M.E.G-L.; Jones, Scott; Leong, Stan; Russell, A. D.

doi:10.1053/jhin.2001.1174

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…The observation that RND–MFP–OMF efflux systems in both E. coli (AcrAB [52–54]) and P. aeruginosa (MexAB–OprM [55], MexCD–OprJ [56], MexEF–OprN [56] and MexJK [57]) accommodate both biocides and clinically important antibiotics has added fuel to the debate on biocide–antibiotic co‐resistance and the possible selection of multiply antibiotic‐resistant strains by biocides [9,58–64,64a]. While it appears that such multidrug efflux systems are unlikely to facilitate resistance to biocides used at the recommended ‘working’ concentrations of these agents, the risk of residual biocide levels selecting pump‐producing mutants that are concomitantly resistant to clinically relevant antibiotics is of some concern [65].…”

Section: Antibiotic–biocide Cross‐resistancementioning

confidence: 99%

Efflux-mediated multiresistance in Gram-negative bacteria

Poole

2004

Clinical Microbiology and Infection

520

407

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Multiresistance in Gram-negative pathogens, particularly Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Acinetobacter spp. and the Enterobacteriaceae, is a significant problem in medicine today. While multiple mechanisms often contribute to multiresistance, a broadly distributed family of three-component multidrug efflux systems is an increasingly recognised determinant of both intrinsic and acquired multiresistance in these organisms. Homologues of these efflux systems are also readily identifiable in the genome sequences of a wide range of Gram-negative organisms, pathogens and non-pathogens alike, where they probably promote efflux-mediated resistance to multiple antimicrobials. Significantly, these systems often accommodate biocides, raising the spectre of biocide-mediated selection of multiresistance in Gram-negative pathogens. While there is some debate as to the natural function of these efflux systems, only some of which are inducible by their antimicrobial substrates, their contribution to resistance in a variety of pathogens nonetheless makes them reasonable targets for therapeutic intervention. Indeed, given the incredible chemical diversity of substrates accommodated by these efflux systems, it is likely that many novel or yet to be discovered antimicrobials will themselves be efflux substrates and, as such, efflux inhibitors may become an important component of Gram-negative antimicrobial therapy.

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Section: Antibiotic–biocide Cross‐resistancementioning

confidence: 99%

Efflux-mediated multiresistance in Gram-negative bacteria

Poole

2004

Clinical Microbiology and Infection

520

407

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“…The molecular and biochemical mechanisms of bacterial resistance to toxic chemicals have been studied in detail for antibiotics, where the resistance is exerted by mechanisms for example enzymatic inactivation, passive exculsion from the cell or active efflux of the antibiotic molecule (Goessens, 1993;McManus, 1997;Charpentier & Tuomanen, 2000;Mitchell & Tuomanen, 2002). Bacterial resistance to biocidal chemicals including organic chemicals and solvents also follows a similar mechanism (Isken & de Bont, 1998;Ng et al, 2002;Sardessai & Bhosle, 2002).…”

Section: Biotic Factorsmentioning

confidence: 99%

Integrative approaches for assessing the ecological sustainability ofin situbioremediation

2009

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Application of microbial metabolic potential (bioremediation) is accepted as an environmentally benign and economical measure for decontamination of polluted environments. Bioremediation methods are generally categorized into ex situ and in situ bioremediation. Although in situ bioremediation methods have been in use for two to three decades, they have not yet yielded the expected results. Their limited success has been attributed to reduced ecological sustainability under environmental conditions. An important determinant of sustainability of in situ bioremediation is pollutant bioavailability. Microbial chemotaxis is postulated to improve pollutant bioavailability significantly; consequently, application of chemotactic microorganisms can considerably enhance the performance of in situ degradation. The environmental fate of degradative microorganisms and the ecological consequence of intervention constitute other important descriptors for the efficiency and sustainability of bioremediation processes. Integrative use of culture-dependent, culture-independent methods (e.g. amplified rDNA restriction analysis, terminal restriction fragment length polymorphism, denaturing/thermal gradient gel electrophoresis, phospholipid fatty acid, etc.), computational and statistical analyses has enabled successful monitoring of the above aspects. The present review provides a detailed insight into some of the key factors that affect the efficiency of in situ bioremediation along with a comprehensive account of the integrative approaches used for assessing the ecological sustainability of processes. The review also discusses the possibility of developing suicidal genetically engineered microorganisms for optimized and controlled in situ bioremediation.

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“…Es difícil saber si existe alguna relación entre la resistencia o susceptibilidad a los biocidas y a los antibióticos, dado que la resistencia a los antimicrobianos puede estar encadenada, pero no siempre se encuentran indicios clínicos de esta relación (17). Si bien algunos autores han postulado que algunos biocidas y antibióticos podrían compartir una "diana" común (24), puede ser que los inhibidores que provocan cambios morfológicos iguales o similares en las células bacterianas por mecanismos diferentes no estén asociados con los mecanismos de resistencia relacionados (25).…”

Section: Discussionunclassified