Biocompatiable silk fibroin/carboxymethyl chitosan/strontium substituted hydroxyapatite/cellulose nanocrystal composite scaffolds for bone tissue engineering

Zhang, Xiaoyun; Chen, Yueping; Han, Jing; Mo, Jun; Dong, Panfeng; Zhuo, Ying-hong; Yang, Feng

doi:10.1016/j.ijbiomac.2019.06.172

Cited by 102 publications

(37 citation statements)

References 68 publications

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“…Table 2 shows the applications of common chitosan derivatives in bone tissue engineering. Increased pore size and mechanical properties promote osteoblast differentiation [61] Trimethyl chitosan N,N,N-trimethyl chitosan-heparin polyelectrolyte multilayer Bionic periosteum Good cell compatibility and support osteoblast differentiation [142] Hydroxypropyltrimethylammonium chloride chitosan Alginate/HACC/oyster shell powder Preparation bracket Improve mechanical properties and enhance stent surface area [143] CMCS is a commonly used in bone tissue engineering [137][138][139][140][141]. In addition to the applications shown in Table 2, CMCS can also be used to make nanofiber scaffolds [144].…”

Section: Bone Tissue Engineering Materialsmentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

654

326

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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Section: Bone Tissue Engineering Materialsmentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

654

326

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“…The shortages of the non-woven fibrous membranes to be used as tissue engineering scaffolds are the small pore sizes and weak mechanical strengths. On the one side, the pore sizes of the fibrous membranes are too small to let cells grow in [77]. For example, Sajesh et al prepared a chitosan fibrous membrane through electrospinning [78].…”

Section: Chitosan-base Polymers In Tissue Repair and 3d Bioprintingmentioning

confidence: 99%

Chitosans for Tissue Repair and Organ Three-Dimensional (3D) Bioprinting

Tian

Fan

et al. 2019

Micromachines

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Chitosan is a unique natural resourced polysaccharide derived from chitin with special biocompatibility, biodegradability, and antimicrobial activity. During the past three decades, chitosan has gradually become an excellent candidate for various biomedical applications with prominent characteristics. Chitosan molecules can be chemically modified, adapting to all kinds of cells in the body, and endowed with specific biochemical and physiological functions. In this review, the intrinsic/extrinsic properties of chitosan molecules in skin, bone, cartilage, liver tissue repair, and organ three-dimensional (3D) bioprinting have been outlined. Several successful models for large scale-up vascularized and innervated organ 3D bioprinting have been demonstrated. Challenges and perspectives in future complex organ 3D bioprinting areas have been analyzed.

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“…Bone deformities from congenital deformity, traumatic injury, and oncologic resection severely affect patients' physical function and mental health. Although autologous, allograft, or xenograft bone transplantations can repair dysfunctional or defect bones in clinic, many limitations still need to be addressed: transplanted bone infection or instability, insufficient transplanted volume, Porosity of all scaffolds was measured using a previously described liquid displacement method [26]. All samples were first cut into the same size, and completely immersed into measuring cylinder with a known volume of anhydrous ethanol (V1).…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effects on Incorporation of β-Tricalcium Phosphate and Graphene Oxide Nanoparticles to Silk Fibroin/Soy Protein Isolate Scaffolds for Bone Tissue Engineering

Liu

Zheng

et al. 2020

Polymers

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In bone tissue engineering, an ideal scaffold is required to have favorable physical, chemical (or physicochemical), and biological (or biochemical) properties to promote osteogenesis. Although silk fibroin (SF) and/or soy protein isolate (SPI) scaffolds have been widely used as an alternative to autologous and heterologous bone grafts, the poor mechanical property and insufficient osteoinductive capability has become an obstacle for their in vivo applications. Herein, β-tricalcium phosphate (β-TCP) and graphene oxide (GO) nanoparticles are incorporated into SF/SPI scaffolds simultaneously or individually. Physical and chemical properties of these composite scaffolds are evaluated using field emission scanning electron microscope (FESEM), X-ray diffraction (XRD) and attenuated total reflectance Fourier transformed infrared spectroscopy (ATR-FTIR). Biocompatibility and osteogenesis of the composite scaffolds are evaluated using bone marrow mesenchymal stem cells (BMSCs). All the composite scaffolds have a complex porous structure with proper pore sizes and porosities. Physicochemical properties of the scaffolds can be significantly increased through the incorporation of β-TCP and GO nanoparticles. Alkaline phosphatase activity (ALP) and osteogenesis-related gene expression of the BMSCs are significantly enhanced in the presence of β-TCP and GO nanoparticles. Especially, β-TCP and GO nanoparticles have a synergistic effect on promoting osteogenesis. These results suggest that the β-TCP and GO enhanced SF/SPI scaffolds are promising candidates for bone tissue regeneration.

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Biocompatiable silk fibroin/carboxymethyl chitosan/strontium substituted hydroxyapatite/cellulose nanocrystal composite scaffolds for bone tissue engineering

Cited by 102 publications

References 68 publications

Chitosan Derivatives and Their Application in Biomedicine

Chitosan Derivatives and Their Application in Biomedicine

Chitosans for Tissue Repair and Organ Three-Dimensional (3D) Bioprinting

Synergistic Effects on Incorporation of β-Tricalcium Phosphate and Graphene Oxide Nanoparticles to Silk Fibroin/Soy Protein Isolate Scaffolds for Bone Tissue Engineering

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