Biocompatibility and Adhesion Formation of Different Endoloop Ligatures in Securing the Base of the Appendix

Delibegović, Samir; Katica, Muhamed; Latić, Ferid; Jakić-Razumović, Jasminka; Koluh, Anhel; Njoum, Mahmoud T M

doi:10.4293/108680813x13654754534116

Cited by 9 publications

(8 citation statements)

References 15 publications

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“…This might be due to the fact that it was the only braided type of suture evaluated, which could therefore have induced a more pronounced inflammation process. This also corresponds with other studies [24,25]. …”

Section: Discussionmentioning

confidence: 49%

Polyvinylidene Fluoride as a Suture Material: Evaluation of Comet Tail-Like Infiltrate and Foreign Body Granuloma

et al. 2015

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Background: Biocompatibility and tissue integration of a surgical suture are decisive factors for wound healing and therefore for the success of sutures. The optimal suture material is still under discussion. Polyvinylidene fluoride (PVDF) is described to have superior properties of biocompatibility and is therefore frequently used as a mesh component. Only little information is available about its use as a suture material. The aim of this study was to evaluate the biocompatibility of PVDF as a suture material in comparison to 5 different established sutures in a rat model. Methods: In 30 male rats, a monofilamental PVDF suture (Resopren®) and 5 established control suture materials [polyester (Miralene®), polytetrafluoroethylene (Gore®), poliglecaprone (Monocryl®), polydioxanone (Monoplus®), polyglactin 910 (Vicryl®), USP size 3-0] were placed in the subcutaneous layer of the abdominal wall without knot or tension. After 3, 7 or 21 days, the abdominal walls were explanted for histopathological and immunohistochemical investigation with special regard to the size and quality of foreign body granuloma and the length of the comet tail-like infiltrate (CTI). Results: The PVDF sutures showed the smallest size of foreign body granuloma (60 ± 14 µm) and the smallest CTI length (343 ± 60 µm) of all polymers after 21 days. Only PVDF (Resopren) and polydioxanone (Monoplus) showed a significant collagen I/III ratio increase between days 3 and 21 (p = 0.009 and p = 0.016). The quality of foreign body reaction regarding inflammation, proliferation and fibrotic remodeling was similar between all suture materials. Conclusions: Our data indicate that monofilamental PVDF sutures show a favorable foreign body reaction with small granuloma sizes and CTI length in comparison to established sutures. Its use as a suture material in general surgery could therefore be extended in the future. To reinforce these findings, further clinical studies need to be conducted.

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Section: Discussionmentioning

confidence: 49%

Polyvinylidene Fluoride as a Suture Material: Evaluation of Comet Tail-Like Infiltrate and Foreign Body Granuloma

et al. 2015

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“…The differences between the level of inflammation and foreign body reaction to different materials used in laparoscopic appendectomy favour the use of a stapler and plastic clips [47]. Also, the creation of adhesion in the area of the base of the appendix is lowest when a stapler is used [48]. It may be said that these characteristics of the stapler may be an advantage in taking care of the base of the appendix during laparoscopic appendectomy.…”

Section: The Position Of the Patient Equipment And The Surgical Teammentioning

confidence: 99%

Acute Appendicitis: Diagnosis and Treatment, with Special Attention to a Laparoscopic Approach

Delibegović¹

2015

Emerg Med (Los Angel)

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Acute appendicitis is one of the most common causes of acute abdomen. It may occur from the time of infancy to old age, but the peak age of incidence is in the second and third decades of life. The diagnosis is based on a careful history and physical examination. In patients who have atypical clinical and laboratory findings, US, CT, MRI, a scoring system and laparoscopy can be used. Laparoscopic appendectomy is a safe and effective method for the treatment of appendicitis. It has proven advantages in relation to the open method: less post-operative pain, and a short stay in hospital, quicker recovery and return to normal activities. The causes of unsuccessful procedures vary, and most of the reasons for conversion occur due to the operator's lack of experience. In general, laparoscopic appendectomy has advantages, but it must be borne in mind that surgical experience in laparoscopic techniques is a precondition for surgeons to expect clinical benefits from laparoscopic appendectomy. In clinical conditions, where surgical experience is present, and the necessary equipment, the use of laparoscopy and laparoscopic appendectomy may be recommended in all patients with suspected appendicitis, if laparoscopy itself is not contra-indicated or is not feasible.

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“…Laparoscopic appendectomy as a surgical technique for dealing with the appendix, has wide-The most frequently used technique for closing the appendiceal stump is the single endoloop ligature, 2,3 whilst non-resorbable polymer plastic clips are an alternative technique used to close the appendiceal stump more quickly and cheaply than standard methods. 1 In contrast to these, titanium stapler clips may also be used successfully to treat all forms of acute appendicitis.…”

Section: Introductionmentioning

confidence: 99%

“…There are reports whose results indicate monitoring local inflammatory responses. 2,7,13,14 Reports describing changes in haematological parameters in the peripheral blood in the post-operative period in treated patients are few. As a result, little is known about how non-resorbable linear titanium stapler clips affect blood cells after appendectomy.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the haematological profile after appendectomy using linear titanium stapler clips: An experimental study in rats

Bajrić¹,

Katica²,

Katica³

et al. 2021

Scripta Medica

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Introduction: The technique of closing the appendiceal stump using linear titanium stapler clips is being used more and more frequently in laparoscopic surgery, despite the good practice in the use of resorbable single endoloop vicryl ligatures and/or the non-resorbable plastic hem-o-lok clips. No light has been shed on potential undesirable effects on the haemathological profile of the use of titanium stapler clips. This experimental study aimed at establishing any possible undesirable effect of linear titanium stapler clips and single resorbable vicryl endoloop ligatures on the blood cells in rats following appendectomy. Methods: A total of 70 adult rats were used, divided into a control group (n = 10), and two experimental groups (n = 30 + 30). The appendices were removed from the rats in the first experimental group using titanium stapler clips and in the second experimental group the appendiceal stump using resorbable endoloop vicryl ligatures was closed. In both experimental groups three sub-groups with ten animals each were formed, from which peripheral blood from a tail vein on days 7, 28 and 60 was removed postoperatively, in order to assess the usual haematological parameters. Stained blood smears were also analysed in order to establish any poikilocytotic erythrocytes present. Results: In the first experimental group, with the titanium stapler clips, more than 25 % neutrophils were found on day 7, which is a significantly different result (p < 0.05) to the control group. In the second experimental group, there were more neutrophils than in the titanium stapler clips group, especially on days 7 and 60 and the results of these two sub-groups differ statistically significantly, p < 0.05. Hypochromia was found in the endoloop vicryl ligatures group, as well as in the titanium stapler clips sub-group on day 28, due to lower haemoglobin values which were significantly different to the control group, p < 0.05. Moderate levels of annulocytes, spherocytes and stomatocytes were found in most experimental groups. Conclusion: The results of this study favour the use of linear titanium stapler clips over resorbable single endoloop vicryl ligatures, because a less unfavourable effect was established on the blood cells of the experimental rats with their use.

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Biocompatibility and Adhesion Formation of Different Endoloop Ligatures in Securing the Base of the Appendix

Abstract: A milder postoperative inflammatory change was noted with polydioxanone Endoloop ligatures than with polyglactin ligatures.

Cited by 9 publications

References 15 publications

Polyvinylidene Fluoride as a Suture Material: Evaluation of Comet Tail-Like Infiltrate and Foreign Body Granuloma

Polyvinylidene Fluoride as a Suture Material: Evaluation of Comet Tail-Like Infiltrate and Foreign Body Granuloma

Acute Appendicitis: Diagnosis and Treatment, with Special Attention to a Laparoscopic Approach

Assessment of the haematological profile after appendectomy using linear titanium stapler clips: An experimental study in rats

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