Biocompatibility and biodegradability of metal organic frameworks for biomedical applications

Singh, Namita; Qutub, Somayah; Khashab, Niveen M.

doi:10.1039/d1tb01044a

Cited by 134 publications

(82 citation statements)

References 119 publications

(124 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The terephthalic ligand was considered to have a very low toxicity and its LD50 is more than 5000 mg/Kg by oral administration [ 39 ]. The Fe-MILs tollerability was reported to be above 1 mg/mL in vitro and more than 100 mg/Kg in vivo [ 40 , 41 , 42 ]. The nature and the morphology of the obtained hybrid nanomaterial was assessed through X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) characterizations and the load/release properties determined using a rhodamine dye as luminescent probe.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of MIL-Modified Fe3O4 Magnetic Nanoparticles for Enhancing Uptake and Efficiency of Temozolomide in Glioblastoma Treatment

Pulvirenti

Monforte

Presti

et al. 2022

IJMS

View full text Add to dashboard Cite

A nanometric hybrid system consisting of a Fe3O4 magnetic nanoparticles modified through the growth of Fe-based Metal-organic frameworks of the MIL (Materials Institute Lavoiser) was developed. The obtained system retains both the nanometer dimensions and the magnetic properties of the Fe3O4 nanoparticles and possesses increased the loading capability due to the highly porous Fe-MIL. It was tested to load, carry and release temozolomide (TMZ) for the treatment of glioblastoma multiforme one of the most aggressive and deadly human cancers. The chemical characterization of the hybrid system was performed through various complementary techniques: X-ray-diffraction, thermogravimetric analysis, FT-IR and X-ray photoelectron spectroscopies. The nanomaterial showed low toxicity and an increased adsorption capacity compared to bare Fe3O4 magnetic nanoparticles (MNPs). It can load about 12 mg/g of TMZ and carry the drug into A172 cells without degradation. Our experimental data confirm that, after 48 h of treatment, the TMZ-loaded hybrid nanoparticles (15 and 20 μg/mL) suppressed human glioblastoma cell viability much more effectively than the free drug. Finally, we found that the internalization of the MIL-modified system is more evident than bare MNPs at all the used concentrations both in the cytoplasm and in the nucleus suggesting that it can be capable of overcoming the blood-brain barrier and targeting brain tumors. In conclusion, these results indicate that this combined nanoparticle represents a highly promising drug delivery system for TMZ targeting into cancer cells.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis of MIL-Modified Fe3O4 Magnetic Nanoparticles for Enhancing Uptake and Efficiency of Temozolomide in Glioblastoma Treatment

Pulvirenti

Monforte

Presti

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Metal-organic frameworks (MOFs) are extremely porous crystalline hybrid compounds that connect with metal ions and organic ligands to form 3D structures. MOFs possess a networking structure with organic ligands, containing voids and a wide range of surface areas, making them ideal candidates for biomedical applications [77]. These networks can be modulated to incorporate various ligands and metal ions [78,79].…”

Section: Efforts To Improve Delivery Efficiencymentioning

confidence: 99%

Advances in Nanoparticles for Effective Delivery of RNA Therapeutics

et al. 2022

View full text Add to dashboard Cite

RNA therapeutics, including messenger RNA (mRNA) and small interfering RNA (siRNA), are genetic materials that mediate the translation of genetic direction from genes to induce or inhibit specific protein production. Although the interest in RNA therapeutics is rising globally, the absence of an effective delivery system is an obstacle to the clinical application of RNA therapeutics. Additionally, immunogenicity, short duration of protein expression, unwanted enzymatic degradation, and insufficient cellular uptake could limit the therapeutic efficacy of RNA therapeutics. In this regard, novel platforms based on nanoparticles are crucial for delivering RNAs to the targeted site to increase efficiency without toxicity. In this review, the most recent status of nanoparticles as RNA delivery vectors, with a focus on polymeric nanoparticles, peptidederived nanoparticles, inorganic nanoparticles, and hybrid nanoparticles, is discussed. These nanoparticular platforms can be utilized for safe and effective RNA delivery to augment therapeutic effects. Ultimately, RNA therapeutics encapsulated in nanoparticle-based carriers will be used to treat many diseases and save lives.

show abstract

“…The enlarged specific surface area and high porosity of MOFs increase their carrying capacity (Karami et al., 2021 ). Moreover, the weak coordination bond ensures the biodegradability of MOFs (Singh et al., 2021 ). MOFs are an ideal base material for carbonization due to their high carbon content, uniform composition, and regular structure (Liang et al., 2018 ; Li et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Multimodal imaging and photothermal synergistic immunotherapy of retinoblastoma with tuftsin-loaded carbonized MOF nanoparticles

Zou

et al. 2022

Drug Delivery

View full text Add to dashboard Cite

Retinoblastoma (Rb) represents 3% of all childhood malignancies and seriously endangers children's lives and quality of life. Early diagnosis and treatment can save children's vision as much as possible. Multifunctional nanoparticles have become a research hotspot in recent years and are expected to realize the integration of early diagnosis and early treatment. Therefore, we report a nanoparticle with dual-mode imaging, photothermal therapy, and immune activation: carbonized MOF nanoparticles (CM NPs) loaded with the immune polypeptide tuftsin (CMT NPs). The dual-mode imaging ability, antitumor effect, and macrophage immunity activation ability of these nanoparticles combined with laser irradiation were studied. The biosafety of CMT NPs was detected. The multifunctional magnetic nanoparticles enhanced photoacoustic (PA) and magnetic resonance (MR) imaging in vivo and in vitro , facilitating diagnosis and efficacy evaluation. The combined effect of CMT NPs and laser irradiation was recorded and verified. Through the accumulation of magnetic field nanoparticles in tumors, the photothermal conversion of nanoparticles under laser irradiation led directly to tumor apoptosis/necrosis, and the release of tuftsin induced macrophage M1-type activation, resulting in antitumor immune effects. Enhanced PA/MR imaging CMT NPs have great potential in dual-mode image-guided laser/immune cotherapy. The nanoparticles have high biosafety and have potential in cancer treatment.

show abstract

Biocompatibility and biodegradability of metal organic frameworks for biomedical applications

Abstract: Metal organic frameworks (MOFs) are a unique class of smart hybrid materials that have recently attracted significant interest for catalysis, separation and biomedical applications. Different strategies have been developed to...

Cited by 134 publications

References 119 publications

Synthesis of MIL-Modified Fe3O4 Magnetic Nanoparticles for Enhancing Uptake and Efficiency of Temozolomide in Glioblastoma Treatment

Synthesis of MIL-Modified Fe3O4 Magnetic Nanoparticles for Enhancing Uptake and Efficiency of Temozolomide in Glioblastoma Treatment

Advances in Nanoparticles for Effective Delivery of RNA Therapeutics

Multimodal imaging and photothermal synergistic immunotherapy of retinoblastoma with tuftsin-loaded carbonized MOF nanoparticles

Contact Info

Product

Resources

About