Biocompatibility and degradation of aliphatic segmented poly(ester amide)s: <i>In vitro</i> and <i>in vivo</i> evaluation

Lips, P.A.M.; Luyn, Marja J. A. van; Chiellini, Emo; Brouwer, Linda A.; Velthoen, I.W.; Dijkstra, P.J.; Feijén, Jan

doi:10.1002/jbm.a.30530

Cited by 27 publications

(27 citation statements)

References 19 publications

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“…Whereas the use of PEAs derived from non-amino acid precursors have been studied as cell supporting biomaterials [11,43,44,45] the attachment and spreading behavior of cells on PEAs derived from α−amino acids is notably absent from the literature. In fact our study is only preceded by two previous studies on glycine [31] and l -alanine [20] containing PEAs where it was shown both PEAs to be less favorable to cells.…”

Section: Resultsmentioning

confidence: 99%

Versatile Biodegradable Poly(ester amide)s Derived from α-Amino Acids for Vascular Tissue Engineering

2010

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Biodegradable poly(ester amide) (PEA) biomaterials derived from α-amino acids, diols, and diacids are promising materials for biomedical applications such as tissue engineering and drug delivery because of their optimized properties and susceptibility for either hydrolytic or enzymatic degradation. The objective of this work was to synthesize and characterize biodegradable PEAs based on the α-amino acids l-phenylalanine and l-methionine. Four different PEAs were prepared using 1,4-butanediol, 1,6-hexanediol, and sebacic acid by interfacial polymerization. High molecular weight PEAs with narrow polydispersity indices and excellent film-forming properties were obtained. The incubation of these PEAs in PBS and chymotrypsin indicated that the polymers are biodegradable. Human coronary artery smooth muscle cells were cultured on PEA films for 48 h and the results showed a well-spread morphology. Porous 3D scaffolds fabricated from these PEAs were found to have excellent porosities indicating the utility of these polymers for vascular tissue engineering.

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Section: Resultsmentioning

confidence: 99%

Versatile Biodegradable Poly(ester amide)s Derived from α-Amino Acids for Vascular Tissue Engineering

2010

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“…In the case of subcutaneously implanted devices, their size, shape, mechanical properties, type of biomaterial, implantation duration and even method of implantation can yield a different response. The FBR can be minimized by using materials with mechanical properties similar to those of the surrounding tissue [13][14][15], by incorporating hydrophilic coatings that prevent protein adsorption (biofouling) [16][17][18][19][20] and by using biocompatible materials that do not produce toxic or irritating by-products upon degradation [21][22][23][24]. However, these approaches only minimize the FBR but do not eliminate it altogether.…”

Section: Introductionmentioning

confidence: 99%

Prevention of foreign body reaction in a pre-clinical large animal model

Kastellorizios

Papadimitrakopoulos

Burgess

2015

Journal of Controlled Release

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“…Lips et al investigated aliphatic segmented PEAs, comprising a crystallizable amide phase and a flexible amorphous ester phase for potential use in biomedical applications 48. By varying the amide content and the type of crystallizable amide segments, the polymer's thermal and mechanical properties can readily be tuned.…”

Section: Biocompatibilitymentioning

confidence: 99%

Biodegradable Polymers Derived From Amino Acids

Khan

Saravanan

Farah

et al. 2011

Macromolecular Bioscience

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In the past three decades, the use of polymeric materials has increased dramatically for biomedical applications. Many α-amino acids derived biodegradable polymers have also been intensely developed with the main goal to obtain bio-mimicking functional biomaterials. Polymers derived from α-amino acids may offer many advantages, as these polymers: (a) can be modified further to introduce new functions such as imaging, molecular targeting and drugs can be conjugated chemically to these polymers, (b) can improve on better biological properties like cell migration, adhesion and biodegradability, (c) can improve on mechanical and thermal properties and (d) their degradation products are expected to be non-toxic and readily metabolized/excreted from the body. This manuscript focuses on biodegradable polymers derived from natural amino acids, their synthesis, biocompatibility and biomedical applications. It is observed that polymers derived from α-amino acids constitute a promising family of biodegradable materials. These provide innovative multifunctional polymers possessing amino acid side groups with biological activity and with innumerous potential applications.

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Biocompatibility and degradation of aliphatic segmented poly(ester amide)s: In vitro and in vivo evaluation

Cited by 27 publications

References 19 publications

Versatile Biodegradable Poly(ester amide)s Derived from α-Amino Acids for Vascular Tissue Engineering

Versatile Biodegradable Poly(ester amide)s Derived from α-Amino Acids for Vascular Tissue Engineering

Prevention of foreign body reaction in a pre-clinical large animal model

Biodegradable Polymers Derived From Amino Acids

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