Biocompatibility and degradation of gold-covered magneto-elastic biosensors exposed to cell culture

Menti, C.; Beltrami, M.; Possan, André Luís; Martins, Sandro Tomaz; Henriques, João Antônio Pêgas; Santos, Alexandre Leme Godoy dos; Missell, F.P.; Roesch‐Ely, Mariana

doi:10.1016/j.colsurfb.2016.03.034

Cited by 10 publications

(4 citation statements)

References 45 publications

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“…For silicabased materials, the hemolytic effect which might cause irreversible damage to erythrocytes was thought to be triggered by the reactive oxygen species (ROS) on the surface of the carrier, the high affinity between the tetraalkylammonium groups in the membranes of erythrocytes and silica, and the electrostatic interactions between the membrane proteins and silica. 16,39 The blood compatibility of MSN and CMSN was estimated by hemolysis assay, and the results were displayed in Figure 7A and B. For CMSN, very low hemolysis of rabbit erythrocytes was observed at the concentration of 100-400 μg/mL.…”

Section: Hemocompatibilitymentioning

confidence: 99%

<p>Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility</p>

Hu¹,

Wang²,

Li³

et al. 2020

IJN

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Purpose: The purpose of this research was to study the basic physicochemical and biological properties regarding the application of L-tartaric acid modified chiral mesoporous silica nanoparticle (CMSN) as a drug carrier, and to explore the structure-property relationship of silica-based materials. Methods: CMSN with functions of carboxyl modification and chirality was successfully synthesized through co-condensation method, and the basic characteristics of CMSN, including morphology, structure, wettability, degradation, bio-adhesion and retention ability in gastrointestinal tract (GI tract) were estimated by comparing with non-functionalized mesoporous silica nanoparticles (MSN). Meanwhile, the biocompatibility and toxicity of L-tartaric modification were systematically evaluated both in vitro and in vivo through MTT cell viability assay, cell cycle and apoptosis assay, hemolysis assay, histopathology examination, hematology analysis, and clinical chemistry examination. Results: CMSN and MSN were spherical nanoparticles with uniform mesoporous structure. CMSN with smaller pore size and carboxyl functional groups exhibited better wettability. Besides, CMSN and MSN could dissolve thoroughly in simulated physiological fluids during a degradation period of 1-12 weeks. Interestingly, the in vitro and in vivo behaviors of carriers, including degradation, bio-adhesion and retention ability in the GI tract were closely related to wettability. As expected, CMSN had faster degradation rate, higher mucosa-adhesion ability, and longer retention time. Particularly, CMSN improved the bio-adhesion property in both gastric mucosa and small intestinal mucosa, and prolonged the GI tract retention time to at least 12 h, which meant higher probability for absorption. The biocompatibility and toxicity examination indicated that CMSN was a kind of biocompatible bio-material with good blood compatibility and negligible toxicity, which is required for further applications in biological fields. Conclusion: CMSN with functions of carboxyl modification and chirality had superiority in terms of both physicochemical and biological properties. The in vitro and in vivo behaviors of carriers, including degradation, bio-adhesion, and retention were closely related to wettability.

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Section: Hemocompatibilitymentioning

confidence: 99%

<p>Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility</p>

Hu¹,

Wang²,

Li³

et al. 2020

IJN

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“…In particular, Menti et al analyzed the degradation of a bare Metglas 2826MB resonator when exposed to cell culture and compared it with a gold-covered Metglas resonator. 95 By this analysis, they observed that the bare Metglas ribbons degrade on contact with the cell culture solution, causing a frequency shift and hence contributing to erroneous sensing results. On the contrary, the coating of the resonator with a gold layer protects the sensor from degradation and increases its biocompatibility.…”

Section: ■ Application Fields Of Magnetoelastic Resonance Devicesmentioning

confidence: 99%

“…Inversely, magnetoelastic sensors have been also employed to follow biological degradation processes. In particular, Menti et al analyzed the degradation of a bare Metglas 2826MB resonator when exposed to cell culture and compared it with a gold-covered Metglas resonator . By this analysis, they observed that the bare Metglas ribbons degrade on contact with the cell culture solution, causing a frequency shift and hence contributing to erroneous sensing results.…”

Section: Application Fields Of Magnetoelastic Resonance Devicesmentioning

confidence: 99%

Magnetoelastic Resonance Sensors: Principles, Applications, and Perspectives

et al. 2022

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Magnetoelastic resonators are gaining attention as an incredibly versatile and sensitive transduction platform for the detection of varied physical, chemical, and biological parameters. These sensors, based on the coupling effect between mechanical and magnetic properties of ME platforms, stand out in comparison to alternative technologies due to their low cost and wireless detection capability. Several parameters have been optimized over the years to improve their performance, such as their composition, surface functionalization, or shape geometry. In this review, the working principles, recent advances, and future perspectives of magnetoelastic resonance transducers are introduced, highlighting their potentials as a versatile platform for sensing applications. First, the fundamental principles governing the magnetoelastic resonators performance are introduced as well as the most common magnetoelastic materials and their main fabrication methods are described. Second, the versatility and technical feasibility of magnetoelastic resonators for biological, chemical, and physical sensing are highlighted and the most recent results and functionalization processes are summarized. Finally, the forefront advances to further improve the performance of magnetoelastic resonators for sensing applications have been identified.

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“…While some ME materials are biocompatible, many are inherently toxic to cells and tissues as they are composted of cytotoxic elements such as nickel and molybdenum [18,23]. Therefore, bioinert polymer coating methods are typically utilized with these toxic ME materials to prevent adverse effects on cell viability [24]. Common coatings for ME materials include parylene and its derivatives, polyurethanes, and silanes.…”

Section: Me Substrate Materialsmentioning

confidence: 99%

Magnetoelastic Materials for Monitoring and Controlling Cells and Tissues

Meyers

Ong

2021

Sustainability

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Advances in cell and tissue therapies are slow to be implemented in the clinic due to the limited standardization of safety and quality control techniques. Current approaches for monitoring cell and tissue manufacturing processes are time and labor intensive, costly, and lack commercial scalability. One method to improving in vitro manufacturing processes includes utilizing the coupled magnetic and mechanical properties of magnetoelastic (ME) materials as passive and wireless sensors and actuators. Specifically, ME materials can be used in quantifying cell adhesion, detecting contamination, measuring biomarkers, providing biomechanical stimulus, and enabling cell detachment in bioreactors. This review outlines critical design considerations for ME systems and summarizes recent developments in utilizing ME materials for sensing and actuation in cell and tissue engineering.

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Biocompatibility and degradation of gold-covered magneto-elastic biosensors exposed to cell culture

Cited by 10 publications

References 45 publications

<p>Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility</p>

<p>Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility</p>

Magnetoelastic Resonance Sensors: Principles, Applications, and Perspectives

Magnetoelastic Materials for Monitoring and Controlling Cells and Tissues

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