Biocompatibility and Effectiveness of a Novel, Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial

Abstract

To assess the clinical efficacy of a novel, organic olive oil-based denture adhesive and its effect on Candida albicans growth in maxillary edentulous individuals wearing complete dentures, individuals were selected from two dental schools in Portugal and Spain. Twenty-eight complete dentures were relined, following a standardized protocol. The novel product (test) was compared with a commercialized adhesive (control) and Vaseline (placebo) randomly assigned in a cross-study design. The retention resistance was measured with a gnathometer and a dynamometer. The patients related outcome evaluations with a five-point questionnaire, and the Candida albicans growth in a Sabouraud dextrose agar (SDA) medium was used to evaluate differences between the placebo and experimental product. Twenty-three participants were included. The dynamometer evaluation showed significant differences between not using a denture adhesive and using either (experimental, p = 0.03; control, p = 0.04) and no significant differences between the two adhesives (p > 0.05). In the subjective analysis, the experimental adhesive showed a significantly longer effectiveness (p = 0.001), and the control reported better results in taste (p = 0.03) and in chewing (p = 0.001). The test adhesive showed better (p < 0.001) Candida albicans growth inhibition. The experimental adhesive showed longer effectiveness than the control and the placebo with a better inhibition capacity for the growth of Candida albicans. Patients reported better abilities for speech, chewing, taste, and retirement in the control adhesive.

The effect of using denture adhesives on patient satisfaction with complete dentures; a randomized clinical trial

“…Our findings indicated no significant difference in the ease of cleaning between Corega and Olivafix, which is consistent with results previously observed by Polychronakis [30]. However, Olivafix was found to be easily solubilized by denture cleansers due to its oil-based components which were also found to have antioxidant, anti-inflammatory, and antimicrobial properties and hence Olivafix can inhibit growth of microorganisms even if adhesive remnants were not completely removed, making Olivafix another attractive option for denture wearers [ 32 ].…”

O uso do adesivo protético está associado a uma melhora no desempenho mastigatório dos usuários de próteses totais? Uma revisão sistematizada

“…Neste contexto, tem sido comprovado cientificamente que os adesivos para próteses são excelentes opções para os pacientes, proporcionando maior conforto e aprimorando o desempenho da função (AZEVEDO et al, 2021). Tratam-se de produtos comercialmente disponíveis para fixar uma prótese removível à mucosa oral, com o intuito de aprimorar a retenção e a estabilidade e evitar que o alimento fique retido sob a prótese (SHU et al, 2021).…”