Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering

Wang, Huanan; Li, Yubao; Zuo, Yi; Li, Jihua; Ma, Sansi; Cheng, Lin

doi:10.1016/j.biomaterials.2007.04.014

Cited by 719 publications

(517 citation statements)

References 49 publications

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“…However, since it is very difficult to control adsorbed water content in the composites, this nano FHAp content is only an approximate value. In the TGA curves several steps are observed (Rajendran et al 2002;Singh et al 2008;Wang et al 2007). The first step, showing a small decrease in weight, is associated with adsorbed water-removing when heated above 90°C.…”

Section: Thermo Gravimetric Analysismentioning

confidence: 99%

Synthesis and characterization of poly(4-vinyl pyridine-co-styrene)/FHAP nanocomposite, and its biomedical application

Dhanalakshmi

Vijayalakshmi²,

Narayanan

2013

Appl Nanosci

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Among the composite materials, ceramic/ polymer possesses significant advantages of high mechanical reliability and excellent biocompatibility for applications in load-bearing areas. In this work, PVPCS(Poly (4-vinyl pyridine-co-styrene))/FHAp nanocomposites of varying weight percentages were synthesized and characterized physical-chemically by XRD, FTIR, 31 P NMR, TGA, DTA, and FE-SEM and biologically by antimicrobial and anti-inflammatory assays for evaluating their potential use for biomedical applications. The results indicated that the size and crystallinity of FHAp nanoparticles decrease with increase in PVPCS concentration in the composite. SEM confirmed the presence of FHAp nano rod crystals in PVPCS matrix. The nano PVPCS20/FHAp demonstrated the highest antifungal and antibacterial activity and favorable inhibition of human cell hemolysis. The designed PVPCS/FHAp nanocomposites constitute promising candidates for biomedical applications.

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Section: Thermo Gravimetric Analysismentioning

confidence: 99%

Synthesis and characterization of poly(4-vinyl pyridine-co-styrene)/FHAP nanocomposite, and its biomedical application

Dhanalakshmi

Vijayalakshmi²,

Narayanan

2013

Appl Nanosci

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“…When the concentration of nano-tubes exceeds 0.5 wt%, their orientation within the bers in the longitudinal aspect is disrupted. As mentioned, in order to enhance mechanical properties of polymers by nanoparticles, high amount of nanoparticles must be added to the basic polymer [34][35][36][37][38]. Shor et al added 25% of hydroxyapatite to poly(caprolactone) sca old to increase the mechanical properties of sca old [36].…”

Section: Identi Cation Of the Chemical Structure With Ftirmentioning

confidence: 99%

Effect of Multi-wall Carbon Nanotubes(MWNTs) on Structural and Mechanical Properties of Poly(3-hydroxybutirate) Electrospun Scaffolds for Tissue Engineering Applications

2016

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Abstract. The aim of this study is to evaluate the e ects of Multi-Walled Carbon NanoTubes (MWNTs) on the structural and mechanical properties of poly-3-hydroxybutyrate (P3HB) electrospun sca olds. To achieve optimal properties of the electrospinning machine, P3HB polymer solutions were prepared at di erent concentrations and spinned in di erent electrospinning parameters. After optimization, MWNTs in di erent weight percentages (0.5%, 0.75%, 1%, and 1.25%) were added to the polymer solutions and electrospinned. The e ects of MWNTs on the structure of bers were investigated using Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR) techniques. The addition of MWNTs increased the average ber diameter from 210 (neat P3HB) to 700 nm at 1.25% MWNTs. In addition, SEM photomicrographs and the MATLAB software program showed an increase in porosity from 81% to 84% in the presence of MWNTs. Tensile strength of P3HB/MWNTs composites revealed 158% improvement over pure P3HB sca old. According to mechanical and structural properties, the best amount of MWNTs was 0.5 wt%. Therefore, MWNTs with low percentages can signi cantly improve the mechanical properties of pure P3HB sca old, so that they can become favorable mechanically for tissue engineering applications.

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“…Preparation of n-HA/PA66 composite slurry All the chemical reagents used in this work were in analytical reagent level. n-HA/PA66 composite slurry was prepared using the co-precipitation method in ethanol [3,6]. Briefly, PA66 granules (Asahi Chemical Industry Co. Ltd., Japan) were completely dissolved in anhydrous ethanol solution at 808C for 3 h. The n-HA crystals slurry, prepared by our group using wet synthesis [21], was dispersed by anhydrous ethanol and then gradually added into PA66 solution with vigorously stirring at 808C for another 3 h. A homogeneous composite ethanol slurry was obtained by controlling equal weight ratio of n-HA to PA66 during preparation.…”

Section: Materials Fabricationmentioning

confidence: 99%

“…In a previous study, our research group developed a novel nano-hydroxyapatite/polyamide66 (n-HA/PA66) composite by a co-precipitation method for bone repair and reconstruction [3]. The composite exhibits good biocompatibility, osteogenesis [6,8] and strong bonding between the n-HA crystals and PA66 matrix [20]. In the present study, injectionmoulded PA66 was chosen as the substrate because its mechanical properties match well with the natural bone.…”

Section: Introductionmentioning

confidence: 99%

“…Because of its similarity to the inorganic component of human hard tissues, synthetic hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HA) could be the first candidate for bioactive coating of orthopaedic implants. Various techniques have been investigated for coating HA onto metallic or non-metallic implants, including plasma spraying [10][11][12][13], sol -gel processing [14], electrophoretic deposition [15] and biomimetic coating [16,17].…”

Section: Introductionmentioning

confidence: 99%

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Bioactive composite gradient coatings of nano-hydroxyapatite/polyamide66 fabricated on polyamide66 substrates

Huang

Zuo

et al. 2012

J. R. Soc. Interface.

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Tightly bonding of bioactive coating is the first crucial need for orthopaedic implants. This study describes a novel and convenient technique to prepare bioactive coating with high adhesion on orthopaedic substitutes made of polymeric matrix. Here, a chemical corrosion method has been adopted to fabricate a coating on the surface of injection-moulded polyamide66 (PA66) substrates by corrosive nano-hydroxyapatite/polyamide66 (n-HA/PA66) composite slurry. Scanning electron microscopy observation shows that a porous chemical corrosion region presents between the coating and dense PA66 substrate. Energy-dispersive X-ray spectroscopy analysis indicates that the chemical corrosion region is mainly composed of PA66 matrix, and the coating layer is an n-HA-rich layer. Both the pore size and n-HA composition increase gradually from the polymeric substrate towards the coating surface. Mechanical testing shows the bonding strength can reach 13.7 + 0.2 MPa, which is much higher than that fabricated on polymeric matrix by other coating methods. The gradual transition in coating structure and composition benefits for the interface bonding and for the surface bone-bonding bioactivity. Subsequent cell experiments corroborate n-HA-rich coating and a porous structure is benefitting for cell attachment and proliferation. The convenient coating method could be popularized and applied on similar polymer implants to produce a tightly and porous bioactive coating for bone tissue regeneration.

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Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering

Cited by 719 publications

References 49 publications

Synthesis and characterization of poly(4-vinyl pyridine-co-styrene)/FHAP nanocomposite, and its biomedical application

Synthesis and characterization of poly(4-vinyl pyridine-co-styrene)/FHAP nanocomposite, and its biomedical application

Effect of Multi-wall Carbon Nanotubes(MWNTs) on Structural and Mechanical Properties of Poly(3-hydroxybutirate) Electrospun Scaffolds for Tissue Engineering Applications

Bioactive composite gradient coatings of nano-hydroxyapatite/polyamide66 fabricated on polyamide66 substrates

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