Biocompatibility and osteogenic activity of Zr−30Ta and Zr−25Ta−5Ti sintered alloys for dental and orthopedic implants

ZHANG, Yi-neng; Yang, Hailin; Juaim, Akram Nasser; CHEN, Xiao-na; LU, Chang; Zou, Ling; WANG, Yin-zhou; Zhou, Xiong‐Wen

doi:10.1016/s1003-6326(23)66151-5

Cited by 5 publications

(8 citation statements)

References 32 publications

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“…Currently, interest in the use of zirconium (Zr) and tantalum (Ta) metals as materials for medical implants has increased [66][67][68][69]. Zirconium exhibits the highest biocompatibility of any metal, followed by pure titanium, niobium, and tantalum [66].…”

Section: Methodsmentioning

confidence: 99%

“…Kulkarni and Kakandikar [68] also note such unique properties of zirconium alloys for biomedical applications as the formation of an internal bone-like apatite layer as well as interaction with magnetic resonance imaging (MRI) diagnostics with better compatibility and low magnetic susceptibility. Zhang Y. et al ( 2023) investigated the biocompatibility and osteogenic activity of sintered Zr-30Ta and Zr-25Ta-5Ti alloys for dental and orthopedic implants using cell culture experiments [69] and found that due to the chemical composition of these newly developed alloys, they have better biocompatibility compared to commercially pure titanium. Due to their high strength and chemical stability, Zr and Ta are very promising as orthopedic biomaterials.…”

Section: Methodsmentioning

confidence: 99%

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A Brief Review of Current Trends in the Additive Manufacturing of Orthopedic Implants with Thermal Plasma-Sprayed Coatings to Improve the Implant Surface Biocompatibility

et al. 2023

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The demand for orthopedic implants is increasing, driven by a rising number of young patients seeking an active lifestyle post-surgery. This has led to changes in manufacturing requirements. Joint arthroplasty operations are on the rise globally, and recovery times are being reduced by customized endoprostheses that promote better integration. Implants are primarily made from metals and ceramics such as titanium, hydroxyapatite, zirconium, and tantalum. Manufacturing processes, including additive manufacturing and thermal plasma spraying, continue to evolve. These advancements enable the production of tailored porous implants with uniform surface coatings. Coatings made of biocompatible materials are crucial to prevent degradation and enhance biocompatibility, and their composition, porosity, and roughness are actively explored through biocompatibility testing. This review article focuses on the additive manufacturing of orthopedic implants and thermal plasma spraying of biocompatible coatings, discussing their challenges and benefits based on the authors’ experience with selective laser melting and microplasma spraying of metal-ceramic coatings.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

A Brief Review of Current Trends in the Additive Manufacturing of Orthopedic Implants with Thermal Plasma-Sprayed Coatings to Improve the Implant Surface Biocompatibility

et al. 2023

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“…Due to outstanding mechanical properties [1-4], good anti-neutron irradiation resistance [5][6][7][8][9], superior corrosion resistance properties [10][11][12][13], good biocompatibility [14][15][16], and so forth, zirconium (Zr) and its alloys have important application potential in the fields of nuclear technologies, aerospace, chemical research, biomedical industries, etc. [17].…”

mentioning

confidence: 99%

Advances in Zr-Based Alloys

Dong,

Tan

2024

Crystals

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“…Osseointegration, or the fusion of the implant surface with the bone [6][7][8][9][10]; • Bone regeneration, the process by which the body builds new bone tissue [11][12][13][14][15];…”

mentioning

confidence: 99%

“…Osseointegration, or the fusion of the implant surface with the bone [6][7][8][9][10]; • Bone regeneration, the process by which the body builds new bone tissue [11][12][13][14][15]; • Antibacterial ability, the ability of the implant to inhibit or slow down bacterial growth [16][17][18][19][20]; • Biocompatibility, the ability of the material to be integrated into the body without clinical complications and to induce the required cellular or tissue response [9,[21][22][23][24][25].…”

mentioning

confidence: 99%

Dental Implants: Modern Materials and Methods of Their Surface Modification

Sotova,

Yanushevich,

Kriheli

et al. 2023

Materials

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The development of dental implantology is based on the detailed study of the interaction of implants with the surrounding tissues and methods of osteogenesis stimulation around implants, which has been confirmed by the increasing number of scientific publications presenting the results of studies related to both the influence of the chemical composition of dental implant material as well as the method of its surface modification on the key operational characteristics of implants. The main materials for dental implant manufacturing are Ti and its alloys, stainless steels, Zr alloys (including ceramics based on ZrO2), and Ta and its alloys, as well as other materials (ceramics based on Al2O3, Si3N4, etc.). The review presents alloy systems recommended for use in clinical practice and describes their physical–mechanical and biochemical properties. However, when getting into the body, the implants are subjected to various kinds of mechanical influences, which are aggravated by the action of an aggressive biological environment (electrolyte with a lot of Cl− and H+); it can lead to the loss of osteointegration and to the appearance of the symptoms of the general intoxication of the organism because of the metal ions released from the implant surface into the biological tissues of the organism. Since the osteointegration and biocompatibility of implants depend primarily on the properties of their surface layer (it is the implant surface that makes contact with the tissues of the body), the surface modification of dental implants plays an important role, and all methods of surface modification can be divided into mechanical, physical, chemical, and biochemical methods (according to the main effect on the surface). This review discusses several techniques for modifying dental implant surfaces and provides evidence for their usefulness.

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Biocompatibility and osteogenic activity of Zr−30Ta and Zr−25Ta−5Ti sintered alloys for dental and orthopedic implants

Cited by 5 publications

References 32 publications

A Brief Review of Current Trends in the Additive Manufacturing of Orthopedic Implants with Thermal Plasma-Sprayed Coatings to Improve the Implant Surface Biocompatibility

A Brief Review of Current Trends in the Additive Manufacturing of Orthopedic Implants with Thermal Plasma-Sprayed Coatings to Improve the Implant Surface Biocompatibility

Advances in Zr-Based Alloys

Dental Implants: Modern Materials and Methods of Their Surface Modification

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