Biocompatibility and osteogenic potential of human fetal femur-derived cells on surface selective laser sintered scaffolds

Kanczler, Janos M.; Mirmalek-Sani, Sayed-Hadi; Hanley, Neil A.; Ivanov, A.L.; Barry, John J. A.; Upton, Clare E.; Shakesheff, Kevin M.; Howdle, Steven M.; Antonov, Eugeuni N.; Баграташвили, В. Н.; Попов, В. К.; Oreffo, Richard O.C.

doi:10.1016/j.actbio.2009.03.010

Cited by 69 publications

(29 citation statements)

References 34 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using an experimental prototype SLS-80 laser, PLA scaffolds were fabricated with the desired architecture designed and produced by ILIT RAS (Troitsk/Shatura, Moscow, Russia). In the subcutaneous implant model, the SSLS-PLGA scaffolds provide a platform to differentiate human fetal femur-derived cells to generate new cartilage and osteogenic matrices, as evidenced by staining for Alcian blue/Sirius red and for collagen type I expression (62).…”

Section: Selective Laser Sintering (Sls)mentioning

confidence: 99%

Solid Free-form Fabrication Technology and Its Application to Bone Tissue Engineering

2010

View full text Add to dashboard Cite

The development of scaffolds for use in cell-based therapies to repair damaged bone tissue has become a critical component in the field of bone tissue engineering. However, design of scaffolds using conventional fabrication techniques has limited further advancement, due to a lack of the required precision and reproducibility. To overcome these constraints, bone tissue engineers have focused on solid free-form fabrication (SFF) techniques to generate porous, fully interconnected scaffolds for bone tissue engineering applications. This paper reviews the potential application of SFF fabrication technologies for bone tissue engineering with respect to scaffold fabrication. In the near future, bone scaffolds made using SFF apparatus should become effective therapies for bone defects.

show abstract

Section: Selective Laser Sintering (Sls)mentioning

confidence: 99%

Solid Free-form Fabrication Technology and Its Application to Bone Tissue Engineering

2010

View full text Add to dashboard Cite

show abstract

“…There are lots of current limitation for the chemical methods due to the high impurity, lack of producing ideal scaffold for in-vivo applications [21]. On the other hand, physical treatments to the surface using laser ablation [23], plasma [24] or UV photo-curing [22] seems to offer solutions for improved functionality and biocompatibility of material implants inside the biological environment [23].…”

Section: Introductionmentioning

confidence: 99%

“…The resulting modified surfaces are free from contamination. They also could improve functionality and biocompatibility of materials which subsequently could be active implants inside the biological environment [24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Laser Surface Modification of Poly (e-caprolactone) Scaffold for Artificial Skin Applications

Hakeam¹,

Eid²,

Sharaf³

et al. 2013

Am. J. Biomed. Sci.

View full text Add to dashboard Cite

Hard implants undergo detachment from the host tissues due to inadequate biocompatibility, poor adhesion and subsequent cell integration. Thereby, surface engineering seems to offer solutions for improved functionality and biocompatibility of material implants inside the biological environment. Polycaprolactone (PCL) thin film has been fabricated via uniaxial compression technique. Pulsed excimer laser was used to modify the PCL surface roughness. The laser pulses induced the formation of nanoripples on the membrane surface. The effect of laser parameters (pulse rate, energy and number of pulses) on the development of the nanoripples was studied. The surface morphology, roughness and the scaffold biocompatibility and cell viability were characterized using scanning electron microscopes (SEM), atomic force microscope (AFM) and MTT assay micro-plate reader. This work showed that applying laser pulses at different rates significantly modified the surface criteria. The modified scaffold was more biocompatible, rough, with enhanced cell attachment, proliferation and provided adequate host for cells to differentiate rather than the unmodified scaffold. The results clearly revealed that the modified scaffold with nanoripples on its surface could be a candidate implant material for artificial skin applications.

show abstract

“…Up to now, several polymer-based bone scaffolds have been fabricated via SLS technique, and these polymers mainly contain polyetheretherketone (PEEK) [5], poly(L-lactide-co-glycolide) (PLGA) [6], poly-e-caprolactone (PCL) [7][8][9], polylactic acid (PLA) [10,11], poly (vinyl alcohol) (PVA) [12][13][14]. Bioactive ceramics, such as hydroxyapatite (HA) [15,16] and calcium phosphate, are often added to these polymers for enhancing the osteoconductive capacity [17].…”

Section: Introductionmentioning

confidence: 99%

Microsphere-based selective laser sintering for building macroporous bone scaffolds with controlled microstructure and excellent biocompatibility

Liu

Jiaqi

et al. 2015

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Biocompatibility and osteogenic potential of human fetal femur-derived cells on surface selective laser sintered scaffolds

Cited by 69 publications

References 34 publications

Solid Free-form Fabrication Technology and Its Application to Bone Tissue Engineering

Solid Free-form Fabrication Technology and Its Application to Bone Tissue Engineering

Laser Surface Modification of Poly (e-caprolactone) Scaffold for Artificial Skin Applications

Microsphere-based selective laser sintering for building macroporous bone scaffolds with controlled microstructure and excellent biocompatibility

Contact Info

Product

Resources

About