Biocompatibility and retinal support of a foldable capsular vitreous body injected with saline or silicone oil implanted in rabbit eyes

Wang, Peijuan; Gao, Qianying; Jiang, Zhaoxin; Lin, Jintian; Liu, Yaqin; Chen, Jiajia; Zhou, Lian; Li, Huaiyang; Yang, Qin; Wang, Ting

doi:10.1111/j.1442-9071.2011.02664.x

Cited by 27 publications

(17 citation statements)

References 26 publications

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“…In our previous study28, we found that most of FCVB-implanted eyes developed cataracts after a long-term tamponade. In order to better observe fundus, we had to perform lensectomy which lead to secondary lesion.…”

Section: Discussionmentioning

confidence: 78%

“…In the PVA + FCVB group, lensectomy was performed during par plana vitrectomy (PPV) surgery. Our prior study28 revealed that severe cataracts occurred most frequently in FCVB implantated eyes and that this led to a failure to observe the fundus. In order to avoid lesions from a second surgery, the lens and vitreous were removed at the same time during vitrectomy.…”

Section: Resultsmentioning

confidence: 99%

“…The decrease of G′ and G″ (lost of viscoelasticity) may due to the breakage of crosslinking points, caused by biodegradation. Our previous studies demonstrated that the FCVB had cellular barrier function and could avoid silicone oil emulsification and migration2831. Therefore, the FCVB could also serve as an isolator in order to avoid PVA hydrogel biodegradation or absorption and displayed better all-round retina support.…”

Section: Discussionmentioning

confidence: 99%

“…After its installation into the vitreous cavity, a balanced salt solution (BSS) or silicone oil (SO) could be injected into the capsule to support the retina and even control the intraocular pressure (IOP) through the tube-valve system2528. Also, the FCVB has good mechanical, optical, and biocompatible properties in vitro and in vivo262728 and has been shown to be flexible, effective, and safe as a vitreous substitute in the treatment of severe human retinal detachment after 3-month and 12-month follow-ups2930. Compared with the traditional method of tamponade (directly injecting the material into the vitreous cavity), this novel FCVB device has been proven to avoid many disadvantages, such as intraocular toxicity, emulsification, high IOP, and keratopathy2831.…”

mentioning

confidence: 99%

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A Novel Vitreous Substitute of Using a Foldable Capsular Vitreous Body Injected with Polyvinylalcohol Hydrogel

Feng

Chen

Liu

et al. 2013

Sci Rep

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Hydrogels may be the ideal vitreous substitutes due to their wonderful physical features and biocompatibility. However, their drawbacks, short residence time, and biodegradation in vivo, have led to the fact that none of them have been approved for clinical use. In this study, we developed a novel approach of using a foldable capsular vitreous body (FCVB) injected with polyvinylalcohol (PVA) hydrogel as a vitreous substitute for long-term tamponade. The 3% PVA hydrogel that was cross-linked by gamma irradiation showed good rheological and physical properties and had no toxicity in vitro. After 180 days retention, the 3% PVA hydrogel inside FCVB remained transparent and showed good viscoelasticity without biodegradation and showed good biocompatibility and retina support. This new approach may develop into a valuable tool to improve the stability performance of PVA hydrogel as a vitreous substitute and to extend the application function of FCVB for long-term implantation in vitreous cavity.

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Section: Discussionmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

A Novel Vitreous Substitute of Using a Foldable Capsular Vitreous Body Injected with Polyvinylalcohol Hydrogel

Feng

Chen

Liu

et al. 2013

Sci Rep

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“…It was designed by simulating the shape of the natural human natural vitreous cavity, possesses excellent mechanical properties, optical properties and biocompatibility, and can adequatelymaintain the shape and intraocular pressure of the eyeball, thus avoiding the risk of repeated replacement of silicone oil and eyeball removal [4] , the complications of silicone oil associated withlong-term compression of the retina, and does not require the placement of patients in special positions, such as the prone position, after the operation. The safety and efficacy of FCVB were initially confirmed through a series of animal studies, a standard process priorto clinical trials [5][6][7] . However, the clinical applications of FCVB havenot been verifiedyet, and the number of previous studies has also been relatively small.…”

Section: Introductionmentioning

confidence: 99%

Study On the Effectiveness and Safety of FCVB Implantation

Zhang

Tian

Zhang

et al. 2019

Preprint

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Background: To investigate the efficacy and safety of the foldable capsular vitreous body(FCVB) in the treatment of vitreoretinal diseases. Methods: A retrospective analysis was conducted involving 20 patients (20 eyes) who underwent FCVB implantation in our hospital from September 2017 to April 2018. All the patients underwent vitrectomyand FCVB implantation, a standard three-port vitrectomy was performed, and the FCVB was implanted into the vitreous cavity. At 6 months after surgery, the visual acuity chart, Goldmann applanation tonometer, fundus photography, B-ultrasound examination, and optical coherence tomography (OCT) examination were performed on the treated eyes.The patients’ vision, intraocular pressure, retinal reattachment, and FCVB status were observed. Results: Compared with the preoperative measurements, there was no change in visual acuity in 18 eyes at 6 months after FCVB implantation, and the difference was not significant (P=1.000); the intraocular pressure of these 18 eyes returned to normal, and the difference was significant (P=0.00001); in fundus photographyimages of these 18 eyes, B-ultrasound,OCT showed good retinal reattachment, FCVB distributed well in the vitreous cavity and evenly supported the vitreous retina and there was no obvious abnormality. The eyes were symmetrical, and the eyeball activity was normal. One patient developed eyeball atrophy after surgery, and one patient developed ocular inflammation after surgery. The condition improved after treatment. Conclusions: FCVB is an effective and safe vitreous substitute during the 6-month implantation period and is able to maintain eye shape, intraocular pressure and good aesthetics. Keywords: Vitreoretinal disease; vitrectomy; FCVB; intraocular pressure.

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Functional evaluation of a novel vitreous substitute using polyethylene glycol sols injected into a foldable capsular vitreous body

Chen

Feng

Liu

et al. 2013

J Biomedical Materials Res

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Polyethylene glycol (PEG) is a short-term (41 days) potential vitreous substitute and is too short for an ideal vitreous substitute. Previously, a foldable capsular vitreous body (FCVB) was designed to mimic vitreous function. The aim of this study is to evaluate whether PEG injected into FCVB can serve as a long-term vitreous substitute. In vitro study, a concentration of 5% (w/v) PEG sols showed natural-like mechanical and optical properties in terms of pH, density, light transmittance, refractive index, interfacial tension, viscosity, rheology, and cytotoxicity. Then in vivo tests, 30 rabbits received standard pars plana vitrectomy, of which 12 eyes were implanted with PEG injected into FCVB, nine eyes were injected with PEG sols alone, and nine others were injected with balance salt solution as control. A clinical evaluation of the anterior segment, fundus, and intraocular pressure was measured pre- and postoperatively up to 180 days, which showed that FCVBs had good retina supporting function, except for a higher incidence of cataracts. Gross pathology, hematoxylin and eosin, and terminal deoxynucleotidyl transferase dUTP nick end labeling staining analysis also showed that FCVBs had good biocompatibility, and that all quadrants of the capsular wall fitted well with the retina. This study demonstrated that PEG injected into FCVB can serve as a long-term vitreous substitute and has potential clinical use.

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Biocompatibility and retinal support of a foldable capsular vitreous body injected with saline or silicone oil implanted in rabbit eyes

Abstract: Introduction: The aim of this study was to evaluate over a 180-day period the biocompatibility and retinal support of a foldable capsular vitreous body injected with either saline or silicone oil implanted in rabbit eyes.

Cited by 27 publications

References 26 publications

A Novel Vitreous Substitute of Using a Foldable Capsular Vitreous Body Injected with Polyvinylalcohol Hydrogel

A Novel Vitreous Substitute of Using a Foldable Capsular Vitreous Body Injected with Polyvinylalcohol Hydrogel

Study On the Effectiveness and Safety of FCVB Implantation

Functional evaluation of a novel vitreous substitute using polyethylene glycol sols injected into a foldable capsular vitreous body

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