Biocompatibility and strength properties of nitinol shape memory alloy suture in rabbit tendon

Kujala, Sauli; Pajala, Ari; Kallioinen, Matti; Pramila, A.; Tuukkanen, Juha; Ryhänen, Jorma

doi:10.1016/s0142-9612(03)00488-5

Cited by 70 publications

(31 citation statements)

References 29 publications

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“…[5,47] The biocompatibility of NiTi was studied in several research works. [48,49] Furthermore, biocompatible silicone [50] can not only thermally isolate the NiTi SMA wires of the actuator from body organs but also can avoid any contact of body fluids with SMA wires. Future coating of the vest or replacing it with a biocompatible polymer [51] may be a solution to ensure the biocompatibility of the vest for future long term implantation of the device.…”

Section: Discussionmentioning

confidence: 99%

Design and Anchorage Dependence of Shape Memory Alloy Actuators on Enhanced Voiding of a Bladder

Hassani

Gammad

Mogan

et al. 2017

Adv Materials Technologies

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for such transformation. [3] Voluntary repeatable shape transformation, material biocompatibility, and small weight of NiTi shape memory alloy (SMA) actuators make them suitable for medical applications. [4][5][6][7][8][9][10][11][12] Usage of NiTi SMA actuators for muscular contraction, [8] artificial anal sphincter, [7] urethral valve, [13] myocardium, [8] drug delivery system, [3] and most recently, voiding of a bladder, [14] has been reported.The previous SMA-based actuator for voiding of a bladder consisted of a flexible vest that covered the bladder surface and physically contracted it upon the actuation of assembled SMA wires. [14] Since a fixed length was considered for SMA wires in this design, the device could be used for only one bladder size that was matched with the total inner diameter of actuator. The proposed design in our study has a more conformable vest that can be fitted for a wider range of bladder sizes in rats with similar body weight, and can substantially improve the voiding volume and energy consumption of the device.The previous SMA-based actuator was proposed for assisting the detrusor muscle in myogenic underactive bladder (UAB) patient with detrusor muscle contractility disorder but intact nerves. [14] Our study broadens the application of the actuating device also to neurogenic UAB patients suffering from both damaged detrusor muscle and nervous system; these patients are not able to rely on the natural nerve pathways to realize The use of shape memory alloy (SMA) actuators to restore voiding of bladder for myogenic under active bladder (UAB) patients is proposed recently. Even though previous work show the unique capability of this technology for bladder voiding, the low voiding volume and high energy consumption of the device limit the advancement of this technique. This study proposes a novel approach using an interlaced configuration to overcome these limitations. In this device, SMA actuators are threaded through rigid anchor points of the flexible vest. The novel anchorage of SMA actuators provides more conformability for the vest and lower energy consumption for the device, while the new interlaced configuration enhances the voiding volume. The device is tested initially on a rubber model for the bladder, then it is implanted in an anesthetized rat, and a voiding volume of more than 20% at 4 V is successfully achieved. A commercial force sensor is integrated with the device to make it suitable for neurogenic UAB patients. The sensor provides a feedback control signal to the patient to initiate the actuation of the device upon fullness of bladder. The overall system is a promising advance over the state-of-the-art providing bladder voiding in UAB patients.

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Section: Discussionmentioning

confidence: 99%

Design and Anchorage Dependence of Shape Memory Alloy Actuators on Enhanced Voiding of a Bladder

Hassani

Gammad

Mogan

et al. 2017

Adv Materials Technologies

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“…Nitinol's high flexibility has been used in, for instance, spectacle frames, telecommunication antennae and actuator valves [17]. This flexibility together with its biocompatibility [18] is currently being exploited in a number of medical applications including surgical instruments, orthopaedic devices and orthodontic arches (see [19] for a recent review).…”

Section: Introductionmentioning

confidence: 99%

Experiments on snap buckling, hysteresis and loop formation in twisted rods

Goss

Heijden

Thompson

et al. 2005

Experimental Mechanics

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We give results of large deflection experiments involving the bending and twisting of 1 mm diameter nickel-titanium alloy rods, up to 2 m in length. These results are compared to calculations based on the Cosserat theory of rods. Details of this theory, formulated as a boundary value problem are presented. The mathematical boundary conditions model the experimental set up. The rods are clamped in aligned chucks and the experiments are carried out under rigid loading conditions. An experiment proceeds by either twisting the ends of the rod by a certain amount and then adjusting the slack, or fixing the slack and varying the amount of twist. In this way commonly encountered phenomena such as snap buckling, the formation of loops, and buckling into and out of planar configurations are investigated. The effect of gravity is discussed.

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“…Pseudoelasticity of SMA is also used for laparoscopic inguinal hernioplasty [77] as well as for producing wires for suture [78]. Shape memory effect is also exploited for stapes prosthesis [79], colonic anastomosis [80,81], and expansion of soft tissue [82].…”

Section: Other Applicationsmentioning

confidence: 99%

Biomedical Applications of Shape Memory Alloys

Petrini

Migliavacca

2011

Journal of Metallurgy

464

200

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Shape memory alloys, and in particular NiTi alloys, are characterized by two unique behaviors, thermally or mechanically activated: the shape memory effect and pseudo-elastic effect. These behaviors, due to the peculiar crystallographic structure of the alloys, assure the recovery of the original shape even after large deformations and the maintenance of a constant applied force in correspondence of significant displacements. These properties, joined with good corrosion and bending resistance, biological and magnetic resonance compatibility, explain the large diffusion, in the last 20 years, of SMA in the production of biomedical devices, in particular for mini-invasive techniques. In this paper a detailed review of the main applications of NiTi alloys in dental, orthopedics, vascular, neurological, and surgical fields is presented. In particular for each device the main characteristics and the advantages of using SMA are discussed. Moreover, the paper underlines the opportunities and the room for new ideas able to enlarge the range of SMA applications. However, it is fundamental to remember that the complexity of the material and application requires a strict collaboration between clinicians, engineers, physicists and chemists for defining accurately the problem, finding the best solution in terms of device design and accordingly optimizing the NiTi alloy properties.

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Biocompatibility and strength properties of nitinol shape memory alloy suture in rabbit tendon

Cited by 70 publications

References 29 publications

Design and Anchorage Dependence of Shape Memory Alloy Actuators on Enhanced Voiding of a Bladder

Design and Anchorage Dependence of Shape Memory Alloy Actuators on Enhanced Voiding of a Bladder

Experiments on snap buckling, hysteresis and loop formation in twisted rods

Biomedical Applications of Shape Memory Alloys

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