Biocompatibility and thermodynamic properties of PEGDA and two of its copolymer

Rekowska, Natalia; Arbeiter, Daniela; Brietzke, Andreas; Konasch, Jan; Rieß, Alexander; Mau, R. Vinh; Eickner, Thomas; Seitz, Hermann; Grabow, Niels; Teske, Michael

doi:10.1109/embc.2019.8857503

Cited by 9 publications

(4 citation statements)

References 20 publications

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“…PEG chemically modified with acrylate groups to produce a photopolymerizable polyethylene glycol diacrylate (PEGDA) [ 91 ]. Originating from PEG, the photo-crosslink hydrogel rapidly encapsulates cells or drugs, demonstrating controllable mechanical properties, adhesion, high controlled release ability, antibacterial effects and antioxidant properties, applied span tissue engineering, drug delivery and other fields [ [92] , [93] , [94] ].…”

Section: Types Of Photo-crosslink Hydrogelsmentioning

confidence: 99%

Research progress of photo-crosslink hydrogels in ophthalmology: A comprehensive review focus on the applications

Zhang,

Yan,

Zheng

et al. 2024

Materials Today Bio

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Section: Types Of Photo-crosslink Hydrogelsmentioning

confidence: 99%

Research progress of photo-crosslink hydrogels in ophthalmology: A comprehensive review focus on the applications

Zhang,

Yan,

Zheng

et al. 2024

Materials Today Bio

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“…18 The latter, which is very hydrophilic, has been widely described in the literature for the elaboration of hydrogels. PEG-based hydrogels have been developed for various applications, but especially medical ones, such as in tissue engineering, 19 drug delivery, 20 3D support for cells, 21,22 artificial materials in the body, 23 glue for neural interfaces, 24 and cartilage replacement. For several years, hydrogels have been of interest because they have the advantage of swelling easily in water without losing their structure.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel Based on Polyhydroxyalkanoate Sulfonate: Control of the Swelling Rate by the Ionic Group Content

et al. 2023

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Hydrogels based on poly(3-hydroxyalkanoate) (PHA) sulfonate and poly(ethylene glycol) diacrylate, PEGDA, are prepared. First, PHA sulfonate is synthesized from unsaturated PHA by a thiol–ene reaction in the presence of sodium-3-mercapto-1-ethanesulfonate. The hydrophilicity of PHAs is considerably increased by adding sulfonate functions, and three amphiphilic PHAs are synthesized, containing 10, 22, or 29% sulfonate functions. Then, hydrogels are formed in the presence of PEGDA having different molar masses, that is, 575 or 2000 g mol–1. The hydrogels show fibrillar and porous structures observed in cryo-MEB with pore sizes that vary according to the content of sulfonated groups (10 to 29 mol %) ranging from 50 to more than 150 nm. Furthermore, depending on the proportions of the two polymers, a variable rigidity is observed from 2 to 40 Pa. In fact, the evaluation of the dynamic mechanical properties of the hydrogel determined by DMA reveals that the less rigid hydrogels hinder the adhesion of Pseudomonas aeruginosa PaO1 bacteria. Finally, these hydrogels swelling up to 5000% are noncytotoxic, allowing the adhesion and amplification of immortalized C2C12 cells, and they are therefore seen as promising materials both for repelling PaO1 bacteria and for amplifying myogenic cells.

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“…Therefore, there is still a need to analyze the effect of post-curing procedures on both the biological and mechanical properties of acrylic photopolymers [ 33 , 35 ]. In earlier studies, we found a strong impact of residual unreacted components, such as monomers and unreacted photoinitiators, on cell viability, which led us to establish a reliable washing procedure [ 36 ]. Improvements in the washing process have enabled us to study the specific influence of various acrylate comonomers, their concentrations and the respective PI concentration on the biocompatibility of the photopolymerized copolymers.…”

Section: Introductionmentioning

confidence: 99%

Thermal, Mechanical and Biocompatibility Analyses of Photochemically Polymerized PEGDA250 for Photopolymerization-Based Manufacturing Processes

Rekowska¹,

Huling²,

Brietzke³

et al. 2022

Pharmaceutics

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Novel fabrication techniques based on photopolymerization enable the preparation of complex multi-material constructs for biomedical applications. This requires an understanding of the influence of the used reaction components on the properties of the generated copolymers. The identification of fundamental characteristics of these copolymers is necessary to evaluate their potential for biomaterial applications. Additionally, knowledge of the properties of the starting materials enables subsequent tailoring of the biomaterials to meet individual implantation needs. In our study, we have analyzed the biological, chemical, mechanical and thermal properties of photopolymerized poly(ethyleneglycol) diacrylate (PEGDA) and specific copolymers with different photoinitiator (PI) concentrations before and after applying a post treatment washing process. As comonomers, 1,3-butanediol diacrylate, pentaerythritol triacrylate and pentaerythritol tetraacrylate were used. The in vitro studies confirm the biocompatibility of all investigated copolymers. Uniaxial tensile tests show significantly lower tensile strength (82% decrease) and elongation at break (76% decrease) values for washed samples. Altered tensile strength is also observed for different PI concentrations: on average, 6.2 MPa for 1.25% PI and 3.1 MPa for 0.5% PI. The addition of comonomers lowers elongation at break on average by 45%. Moreover, our observations show glass transition temperatures (Tg) ranging from 27 °C to 56 °C, which significantly increase with higher comonomer content. These results confirm the ability to generate biocompatible PEGDA copolymers with specific thermal and mechanical properties. These can be considered as resins for various additive manufacturing-based applications to obtain personalized medical devices, such as drug delivery systems (DDS). Therefore, our study has advanced the understanding of PEGDA multi-materials and will contribute to the future development of tools ensuring safe and effective individual therapy for patients.

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Biocompatibility and thermodynamic properties of PEGDA and two of its copolymer

Cited by 9 publications

References 20 publications

Research progress of photo-crosslink hydrogels in ophthalmology: A comprehensive review focus on the applications

Research progress of photo-crosslink hydrogels in ophthalmology: A comprehensive review focus on the applications

Hydrogel Based on Polyhydroxyalkanoate Sulfonate: Control of the Swelling Rate by the Ionic Group Content

Thermal, Mechanical and Biocompatibility Analyses of Photochemically Polymerized PEGDA250 for Photopolymerization-Based Manufacturing Processes

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