Biocompatibility and Toxicity of Polylactic Acid/Ferrosoferric Oxide Nanomagnetic Microsphere

Xiang, Hongzhao; Mu, Yuanhua; Hu, Chengbo; Luo, Xiaobing

doi:10.1155/2017/5429063

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…Serum inorganic phosphate concentration showed a significant increase and decrease (P<0.05) in all groups during 8 weeks as a result of bone repairing process (46). Serum urea concentration showed a significant increase (P<0.05) 8 weeks post-implantation in group D which signified kidney disease (51,52). The changes in haematological and biochemical parameters recorded from this study were related to the cascade of immunological responses caused by materials that used in the development and coating the scaffolds.…”

Section: Discussionmentioning

confidence: 59%

“…According to the liver, spleen and kidney histological properties, an abnormal architecture was observed in all animals thus indicating the form of toxicity related to the products released from the degrading scaffold materials. The severity of the histopathological lesions in the viscera were coated polymers dependent nor development materials and in agreement with earlier reports by Harlan Laboratories (54) and Aguilar et al (55) that documented the absence of treatment-related effects from studies on oral administration of calcium carbonate, Isa et al (56) who has demonstrated the biocompatibilities (nontoxicity and nonimmunogenicity) of CaCO3 nanocrystals and making it suitable candidate for nanomedicine and related fields, Hammadi et al (57) who proved that CaCO3 nanocrystals to be biocompatible and non-toxic by itself, Jaji et al (58) who repoted that CaCO3 is generally safe and the safety of CaCO3 nanocrystals in vivo is dependent on its concentration and route of administration, Zuki et al (15) and Bharatham et al (16) documented the absence of scaffolds materials effects to leak out as they degrade from studies in scaffolds of calcium carbonate, gelatin, dextrin, dextran and alginate, Lee et al (28), Gendler et al (59) and Wiebe et al (60) who reported possibly toxic repercussions of GTA for cells in the direct area; Athanasiou et al (51), Xiang et al (52) who reported toxicity effect and certain problems, especially pertaining to reduction in cell proliferation. The cytocompatibility of the scaffold materials towards cells has been previously proven through in vitro evaluations and it is unlikely for the scaffold materials to cause an adverse toxicity reaction at distant organs of the animals in in vivo evaluations.…”

Section: Discussionmentioning

confidence: 99%

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In Vivo evaluation of the novel nanocomposite porous 3D scaffold in a rabbit model: hematology and biochemistry analysis

Mahmood¹,

Zakaria²,

Razak³

et al. 2019

IJVS

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Issues of safety are very crucial with biomaterials and medical devices. Sixteen male New Zealand White rabbits equally into four groups: Group A, rabbits had part of their radial bone (2 cm, mid shaft) and left empty as a control. Group B, rabbits were implanted with scaffold 5211. Group C, rabbits were implanted with scaffold 5211GTA+Alginate. Group D, rabbits were implanted with 5211PLA. All scaffolds were prepared by freeze-drying method. Blood samples were collected at day 0 and 1 st , 2 nd , 3 rd , 4 th and 8 th week after implantation. The blood examination included complete hemogram and certain serum biochemical parameters. The results showed that there was no significant difference (P>0.05) among each treatment group in comparison with control group (day 0). However, red blood cells, hemoglobin, packed cell volume, mean corpuscular hemoglobin concentration, monocyte, plasma protein, inorganic phosphate, sodium, chloride and urea were significantly increased (P<0.05) among treatment groups at week 8. An abnormal architecture of viscera was observed in all animals, thus indicating a form of toxicity related to the degrading scaffold materials. The severity of histopathological lesions in viscera was not coated polymers dependent nor development materials. In conclusion, implantation of 5211 scaffold with or without coated framework has a significant impact on histopathological and certain hematological and biochemical parameters.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

In Vivo evaluation of the novel nanocomposite porous 3D scaffold in a rabbit model: hematology and biochemistry analysis

Mahmood¹,

Zakaria²,

Razak³

et al. 2019

IJVS

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“…Pocos estudios sobre el uso de nanopartículas de hierro con PLA en prótesis ha sido estudiada, su objetivo se basa en generar memoria reprogramable inducida magnéticamente en un derivado de PLA, con ácido poli-D,L-láctico (PDLLA), pudiendo aplicarse a prótesis no deformables (X. Zheng et al, 2009), o como agentes transportadores de fármacos usando PLA (Xiang et al, 2017). En la inves-tigación de Zhou et al (2013) se fabricaron y caracterizaron andamios de cristales de nanocelulosa (CNC) y anhídrido maleico (MAH) injertados en PLA, como matriz (MPLA/ CNC).…”

Section: Nanopartículas De óXido De Hierrounclassified

Potencial Uso De Nanomateriales Combinados Con Ácido Poliláctico (Pla) en Prótesis Ortopédicas: Una Revisión

Villamarin-Barriga

et al. 2022

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Los materiales tradicionales derivados del petróleo como el polietileno y polipropileno son los más empleados en el campo de la protésica, sin embargo, la tendencia a la protección del medio ambiente amerita el análisis de nuevos materiales biodegradables y biocompatibles. El ácido poliláctico (PLA) es un polímero obtenido a partir de fuentes naturales, que se usa entre muchas aplicaciones en prótesis ortopédicas por su bajo costo. Con el desarrollo de la nanotecnología, pueden incorporarse nanopartículas de diferente naturaleza con el objetivo de mejorar las propiedades mecánicas del PLA, sin embargo, existe información limitada. En este compendio se describen las propiedades físicas y químicas del PLA, así como las condiciones para su impresión en 3D. Se analizan varios nanomateriales tales como nanocelulosa, nanofibras de quitosano, nanotubos de carbono, grafeno, óxido de titanio, nanopartículas de óxido de hierro, nanopartículas de plata, nanopartículas de sílice mesoporosa, entre otras. Se describen estudios referentes sus propiedades químicas, mecánicas y biocompatibilidad. Como resultados se encontró que algunos nanomateriales han sido combinados con PLA, los estudios realizados para comparar sus propiedades mecánicas, muestran mejores resultados usando nanopartículas. Muy pocos estudios in vivo se han realizado, únicamente nanotubos de carbono, grafeno, óxido de titanio, nanopartículas de plata y nanopartículas de sílice mesoporosa. Se concluye que el uso de nanomateriales puede mejorar potencialmente las propiedades mecánicas del PLA, sin embargo, se requieren los estudios experimentales correspondientes, además que se deben usar modelos animales para evaluar su efecto a nivel tisular y determinar si son aptos para la combinación o recubrimiento de prótesis.

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“…Both fundamental physical discoveries and new biological and medical applications are likely to continue to emerge using these techniques. Recent in vitro and in vivo studies confirmed the biocompatibility of the microspheres and the extracts of the microspheres showed no cytotoxic reactivity in the cytotoxicity tests [15], [16]. Experiments also showed that polylactic acid (PLA) coated microspheres containing superparamagnetic Fe 3 O 4 nanoparticles, injected in mice, had no effect on their main organs and blood biochemistry, its performance conforms to clinical requirements, and its biocompatibility conforms to the standard for medical material [16].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Magnetic Nanoparticle-Seeded Microspheres for Magnetomotive and Multimodal Imaging

Marjanović

Nguyen

Ahmad

et al. 2019

IEEE J. Select. Topics Quantum Electron.

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Magnetic iron-oxide nanoparticles have been developed as contrast agents in magnetic resonance imaging (MRI) and as therapeutic agents in magnetic hyperthermia. They have also recently been demonstrated as contrast and elastography agents in magnetomotive optical coherence tomography and elastography (MM-OCT and MM-OCE, respectively). Protein-shell microspheres containing suspensions of these magnetic nanoparticles in lipid cores, and with functionalized outer shells for specific targeting, have also been demonstrated as efficient contrast agents for imaging modalities such as MM-OCT and MRI, and can be easily modified for other modalities such as ultrasound, fluorescence, and luminescence imaging. By leveraging the benefits of these various imaging modalities with the use of only a single agent, a magnetic microsphere, it becomes possible to use a widefield imaging method (such as MRI or small animal fluorescence imaging) to initially locate the agent, and then use MM-OCT to obtain dynamic contrast images with cellular level morphological resolution. In addition to multimodal contrast-enhanced imaging, these microspheres could serve as drug carriers for targeted delivery under image guidance. Although the preparation and surface modifications of protein microspheres containing iron oxide nanoparticles has been previously described and feasibility studies conducted, many questions regarding their production and properties remain. Since the use of multifunctional microspheres could have high clinical relevance, here we report a detailed characterization of their properties and behavior in different environments to highlight their versatility. The work presented here is an effort for the development and optimization of nanoparticle-based microspheres as multi-modal contrast agents that can bridge imaging modalities on different size scales, especially for their use in MM-OCT and MRI imaging.

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Biocompatibility and Toxicity of Polylactic Acid/Ferrosoferric Oxide Nanomagnetic Microsphere

Cited by 5 publications

References 25 publications

In Vivo evaluation of the novel nanocomposite porous 3D scaffold in a rabbit model: hematology and biochemistry analysis

In Vivo evaluation of the novel nanocomposite porous 3D scaffold in a rabbit model: hematology and biochemistry analysis

Potencial Uso De Nanomateriales Combinados Con Ácido Poliláctico (Pla) en Prótesis Ortopédicas: Una Revisión

Characterization of Magnetic Nanoparticle-Seeded Microspheres for Magnetomotive and Multimodal Imaging

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