Biocompatibility, degradability, bioactivity and osteogenesis of mesoporous/macroporous scaffolds of mesoporous diopside/poly( l -lactide) composite

Abstract

Bioactive mesoporous diopside (m-DP) and poly(L-lactide) (PLLA) composite scaffolds with mesoporous/macroporous structure were prepared by the solution-casting and particulate-leaching method. The results demonstrated that the degradability and bioactivity of the mesoporous/macroporous scaffolds were significantly improved by incorporating m-DP into PLLA, and that the improvement was m-DP content-dependent. In addition, the scaffolds containing m-DP showed the ability to neutralize acidic degradation products and prevent the pH from dropping in the solution during the soaking period. Moreover, the scaffolds containing m-DP enhanced attachment, proliferation and alkaline phosphatase activity of MC3T3-E1 cells, which were also m-DP content-dependent. Furthermore, the histological and immunohistochemical analysis results showed that the scaffolds with m-DP significantly promoted new bone formation and improved the materials degraded in vivo, indicating good biocompatibility. The results suggested that the mesoporous/macroporous scaffolds of the m-DP/PLLA composite with osteogenesis had a potential for bone regeneration.

Silane Modified Diopside for Improved Interfacial Adhesion and Bioactivity of Composite Scaffolds

“…Kumar et al fabricated chitosan-diopside composite scaffolds by sol–gel method, and found that introducing DIOP into the scaffolds showed improved bioactivity and biocompatibility [ 17 ]. Liu et al prepared diopside/poly( l -lactide) scaffolds via the solution-casting method, and discovered that the composite scaffolds could significantly enhance the bioactivity and the attachment and proliferation of MC 3 T 3 -E 1 cells [ 18 ]. Therefore, PEEK/PGA composite combined with DIOP might possess good bioactive and biocompatible properties.…”

Regulated Surface Morphology of Polyaniline/Polylactic Acid Composite Nanofibers via Various Inorganic Acids Doping for Enhancing Biocompatibility in Tissue Engineering

“…As a template for tissue repair and regeneration, bioactive scaffolds are degraded and excreted out of the body following induced cell and tissue repair [ 43 ]. In this paper, the degradation properties of the nanofiber scaffolds were evaluated using a mass loss method, as shown in Fig.…”

Designing of porous PMMA/diopside bone cement for non-load bearing applications

“…An amorphous phase was detected on the surface of DP1 and DP2 composites after 28 days along with an emerging apatite peak ( Figure 6(c, f)). Liu et al (2015) observed an increase in apatite deposition with the increase in mesoporous diopside content in poly-L-lactic acid (PLLA) matrix [31]. The composites composed of 40% diopside show better apatite deposition than 20%.…”