2010
DOI: 10.4028/www.scientific.net/amr.177.325
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Biocompatibility of HAP/Ti Gradient Coating by Microarc Oxidation and Biomimetic Process

Abstract: This study is to evaluate the biocompatibility of HAP/Ti gradient coating by microarc oxidation and biomimetic process. Titanium alloys were activated by microarc oxidation (MAO), and immersed in simulated body fluid to prepare HAP/Ti gradient coating. Scanning electron microscopy (SEM) had been used to investigate the microstructure of the coatings. The biocompatibility of the coatings was evaluated by animal acute and subacute toxicity test, micronucleus test, hemolysis test, and oral mucosa test. The result… Show more

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Cited by 2 publications
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“…Security for medical devices has increased in value by governments. A series of international standards for medical devices (ISO 10993) have been published by ISO in 1992, and scientists in China began studying methods for evaluation of medical devices since the late 1970s, thus ensuring safety in the research, production and clinical use, and promotion of the development of medical devices (8,9). Among the biocompatibility tests, cytotoxicity is preferred as a pilot project test and as an important indicator for the evaluation of medical devices as it is simple, fast, has a high sensitivity and can save animals from toxicity (10,11).…”
Section: Introductionmentioning
confidence: 99%
“…Security for medical devices has increased in value by governments. A series of international standards for medical devices (ISO 10993) have been published by ISO in 1992, and scientists in China began studying methods for evaluation of medical devices since the late 1970s, thus ensuring safety in the research, production and clinical use, and promotion of the development of medical devices (8,9). Among the biocompatibility tests, cytotoxicity is preferred as a pilot project test and as an important indicator for the evaluation of medical devices as it is simple, fast, has a high sensitivity and can save animals from toxicity (10,11).…”
Section: Introductionmentioning
confidence: 99%