Biocompatibility of Intracanal Medications Based on Calcium Hydroxide

Abstract

Objective. The aim of this study was to evaluate the rat subcutaneous tissue reaction to calcium hydroxide-based intracanal medicaments, UltraCal XS (calcium hydroxide, barium sulphate, aqueous matrix), Hydropast (calcium hydroxide, barium sulphate, and propyleneglycol), and Calen (Calcium hydroxide, zinc oxide, colophony, and polyethyleneglycol), used as a control. Methods. Forty-eight rats (Rattus Norvegicus Holtzman) were distributed in three groups: Calen, UltraCal XS, and Hydropast. Polyethylene tubes filled with one of the medicaments were implanted in the dorsal subcutaneous. After 7 and 30 days, the implants were removed and the specimens were fixed and embedded in paraffin. Morphological and quantitative analyses were carried out in the HE-stained sections. The numerical density of inflammatory cells in the capsule was evaluated and statistical analyses were performed (P ≤ 0.05). Results. At 7 days, all materials induced an inflammatory reaction in the subcutaneous tissue adjacent to the implants. In all groups, a significant reduction in the number of inflammatory cells and giant cells was verified in the period of 30 days. Conclusion. These results indicate that the calcium hydroxide-based medicaments evaluated present biocompatibility similar to Calen.

Biocompatibility of root filling pastes used in primary teeth

“…Calcium hydroxide is widely 48,[405][406][407][408][409][410][411][412][413][414][415][416]2015 used in dentistry due to its biocompatible properties and antimicrobial, anti-inflammatory and reparative activities (Hauman & Love 2003a,b, Mohammadi & Dummer 2011, de Sousa et al 2011, Gondim et al 2012. The biocompatibility results obtained in this study for calcium hydroxide paste are consistent with those reported by several authors (Holland et al 2001, Semenoff et al 2008, Silva et al 2010, Andolfatto et al 2012).…”

Induction of cytotoxicity, oxidative stress and genotoxicity by root filling pastes used in primary teeth

“…UltraCal XS, Hydropast and Calen paste also provided tissue compatibility (Andolfatto et al . ). Thus, calcium hydroxide‐based pastes may be considered suitable for clinical use in pulp therapy, mainly for teeth with periapical lesions.…”

Morphological and immunohistochemical analysis of the biocompatibility of resin‐modified cements

“…MOs are outstanding by the capacity to ingest and process foreign materials and by acting in the release of chemokines, responsible for the recruitment of inflammatory cells (Ibraguimov, Owens, Su, & Tang, ; Kochanowski et al, ; Yamanaka et al, ). Furthermore, they may fuse and originate MGCs, which are capable of potentiating the proinflammatory response and help in limitation and removal of residues considered non‐inert to the body (Andolfatto et al, ; Costa, Ribeiro, Giro, Randall, & Hebling, ).…”