Biocompatibility of membranes used in the treatment of renal failure

Hoenich, Nicholas A.; Woffindin, C.; Mathews, John N.S.; Vienken, Jörg

doi:10.1016/0142-9612(95)93855-8

Cited by 32 publications

(9 citation statements)

References 11 publications

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“…Hemodialysis membranes with high biocompatibility cause a lower increase in membrane-induced cytokines. 21,22 Therefore, they cause less desialylation of cell components and lipoprotein particles, and so, a lower increase in the total circulating SA level. Also, they do not cause a cumulative increase in the SA level.…”

Section: Discussionmentioning

confidence: 99%

The influence of hemodialysis on serum sialic acid levels in chronic renal failure

et al. 2002

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Background. It has been observed that there is an increase in serum sialic acid level in chronic renal diseases and endstage renal failure requiring hemodialysis, and the hemodialysis procedure causes increased cytokine production. Thus, it is expected that hemodialysis causes increases in the serum levels of acute phase reactants and sialic acid. Nevertheless, the changes in serum sialic acid level in hemodialysis have not been examined sufficiently. In our study, we examined the effect of hemodialysis on serum sialic acid level. Methods. A total of 54 patients on hemodialysis therapy for chronic renal failure (32 men; 22 women) were examined. The patients were evaluated in four groups according to their age, sex, duration of hemodialysis, and whether they were diabetic. Serum sialic acid levels before and after hemodialysis, done with a hemophane membrane, were measured by the thiobarbituric acid method described by Warren. Results. The serum sialic acid levels of chronic renal failure patients requiring hemodialysis were increased with respect to the healthy control group, independent of age, duration of therapy, and whether there was accompanying diabetes. Hemodialysis did not provide clearance of sialic acid; to the contrary, it caused an insignificant increase in serum sialic acid levels. Conclusions. In chronic renal failure, the improved serum sialic acid level probably reaches a definite value, and this value is not affected by factors such as diabetes, age, or sex. Serum sialic acid level is minimally influenced by hemodialysis performed with a hemophane membrane.

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Section: Discussionmentioning

confidence: 99%

The influence of hemodialysis on serum sialic acid levels in chronic renal failure

et al. 2002

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“…Complement activation takes place at the very beginning of the HD period and returns to initial levels at the end of the dialysis session, this degree of activation depending on the type of the membrane [25,28]. It has been postulated that the decreased complement-activating capacity observed in H membrane was caused by blocking of the hydroxyl groups by DEAE [27]. Alternatively, the DEAE of H membranes favors the binding of factor H, a protein known to inhibit the alternative pathway of complement activation [29].…”

Section: Discussionmentioning

confidence: 99%

One-Year Immunological Evaluation of Chronic Hemodialysis in End-Stage Renal Disease Patients

Meier

Fliedner²,

Markert³

et al. 2000

Blood Purif

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Background: Much research has been devoted to the determination of acute leukocyte activation as well as acute cytokines production during and after blood hemodialysis membrane interaction. In contrast, few studies deal with chronic immunological evaluation of T-cell activation markers in hemodialysis. Methods: We evaluated different immune parameters using a modified cellulose low-flux hemophan vs. synthetic high-flux polyamide membrane during 1 year in 35 stable chronic hemodialysis patients. Leukocyte counts, lymphocyte subpopulations, T-cell activation markers (CD69, CD25, HLA-DR, CD54, CD62L, CD45RO, CD11a, CD28), complement-activation products (C3a) and serum elastase were measured at 0, 3, 6 and 12 months in the two patient groups and compared to 13 healthy control subjects. Results: Over dialysis time, all patients showed a significant level elevation of CD69/CD3 (p < 0.005) and CD25/ CD3 (p < 0.005) phenotypes. In contrast, HLA-DR and CD45RO remained unchanged suggesting a truncated pattern of activation. T lymphocyte subset analysis showed in both hemodialyzed groups a significant decrease in the expression of CD54 (ICAM-1) when compared to controls (p < 0.005). C3a and elastase measurements showed a significant upward trend with dialysis time in both hemodialyzed groups. Conclusion: Although the immunological changes seen in chronic hemodialyzed patients must be interpreted in conjunction with their basal uremic states and the membrane permeability properties, our study suggests that 1-year immunological evaluation of hemodialysis membranes biocompatibility is associated with changes in the pattern of chronic T-cell activation, which is in part related to the use of a particular membrane type. Moreover, some key molecules (CD54) are affected in patients with end-stage renal disease undergoing hemodialysis.

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“…Cellulose triacetate is produced from cellulose by conversion of the free hydroxyls to acetyl groups [1]. The absence of any free hydroxyls provides significantly better biocompatibility than cellulosic membranes used earlier, leading to very low levels of complement activation and minimal changes in leukocyte count [2,3]. In addition, the hydrophilic character of cellulose triacetate eliminates the need for adding hydrophilizing agents like polyvinylpyrrolidone during membrane casting, which is commonly used in the manufacture of polysulfone dialyzers [4].…”

Section: Introductionmentioning

confidence: 99%

Transport Characteristics of Asymmetric Cellulose Triacetate Hemodialysis Membranes

et al. 2017

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Aims: The objective of this study was to compare the transport characteristics of highly asymmetric cellulose triacetate (ATA™) membranes with that of both symmetric cellulose triacetate and asymmetric polysulfone membranes. Methods: Data were obtained for solute clearance and sieving coefficients of vitamin B₁₂ and a range of polydisperse dextrans using ATA™ SOLACEA-25H and Optiflux F250NR polysulfone dialyzers. Results for these, and the CT190 symmetric cellulose triacetate dialyzer, were analyzed using available membrane transport models. Results: The ATA™ had the largest solute clearance, although the homogeneous CT190 dialyzer had the highest sieving coefficients. These differences were a direct result of the differences in the underlying membrane morphology, with the asymmetric ATA™ membrane providing much higher diffusive transport rates (and thus higher solute clearance). Conclusions: These results demonstrate the importance of membrane morphology on dialyzer transport and provide important insights into the effective clinical performance observed with the highly asymmetric ATA™ dialyzers.

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Biocompatibility of membranes used in the treatment of renal failure

Cited by 32 publications

References 11 publications

The influence of hemodialysis on serum sialic acid levels in chronic renal failure

The influence of hemodialysis on serum sialic acid levels in chronic renal failure

One-Year Immunological Evaluation of Chronic Hemodialysis in End-Stage Renal Disease Patients

Transport Characteristics of Asymmetric Cellulose Triacetate Hemodialysis Membranes

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