Biocompatibility of Modified Osteoinductive Calcium-Phosphate Coatings of Metal Implants

Abstract

The cellular and molecular aspects of immunological compatibility of modified osteoinductive calcium-phosphate coatings formed on technically pure titanium VT1-0 by the plasma electrolytic oxidation technology are studied. The technique of coating modified the process of human peripheral blood leukocyte activation in vitro. The most pronounced functional changes were observed in neutrophil population during whole blood contact with titanium sample without coating and with coating formed by plasma electrolytic oxidation on titanium alloy. Sealing of the oxidation layer pores by ultradispersed polytetrafluoroethylene leads to reduction of cell activation. Composite coatings with ultradispersed polytetrafluoroethylene applied by the electrophoretic method are characterized by the best biocompatibility. The data demonstrate the possibility of modifying biomaterial surfaces for inflammatory response control.

Comparison between Plasma Electrolytic Oxidation Coating and Sandblasted Acid-Etched Surface Treatment: Histometric, Tomographic, and Expression Levels of Osteoclastogenic Factors in Osteoporotic Rats

“…The PEO surface method favors the addition of Mg, Al, Ti, Ca, and P molecules by providing improved protection against corrosion and wear, and the initial cellular response is higher with Ca and P, in relation to the others, due to their greater biocompatibility and bioactivity [42]. According to Zaporozhets et al, the incorporation of these elements had the capacity to better control local inflammatory responses by modifying the blood leukocyte activation process, which was more evident in neutrophils in contact with the Ti alloy surface [43].…”

Electrodeposited Hydroxyapatite-Based Biocoatings: Recent Progress and Future Challenges

“…(i) Acceptable biological performance embracing biocompatibility, i.e., allowing the human body cell to remain viable, grow, and properly carry out its duties in addition to offering suitable bioactivity, including encouraged formation of apatite, as the main constituent of bone and tooth. (ii) Improved corrosion behavior, not only to prolong the service lifetime of the implant through preventing the failure of the protected implant but also suppresses the toxic ions that may be released from the surface of metallic implant [41][42][43].…”

Enhanced cytocompatibility and osteoinductive properties of sol–gel-derived silica/zirconium dioxide coatings by metformin functionalization

“…The applied scientists in the field of bone engineering are constantly looking for implants with highly osteoinductive properties. [1][2][3][4][5] Efficient osseointegration of implant with newly synthesized tissue is a critical aspect of proper bone regeneration and has substantial impact upon clinical outcome. 6,7 Surface properties, in particular its chemistry, composition, roughness, wettability but also constitution of the adsorbed protein layer, may modulate bone tissue-implant microenvironment and thus determine the success of implantation.…”