Biocompatibility of nanosilver-coated orthodontic brackets: an in vivo study

Abstract

BackgroundNanosilver particles of which antibacterial and antifungal properties have been shown in various in vitro and in vivo studies are used in many medical and dental fields for the prevention of infection. In this study, it is intended to evaluate the biocompatibility of nanosilver-coated brackets.MethodsNanosilver coating process was applied to the standard orthodontic brackets by a physical vapor deposition system. Brackets were coated with nanosilver particles of 1 μ thickness. A total of 12 Wistar Albino rats were included in the study (six) and control (six) groups. For the study and control groups, four nanosilver-coated and four standard brackets were aseptically implanted subcutaneously in the dorsal region of each rat. The brackets were removed with the surrounding tissues on days 7, 14, 30, and 60. The specimens were evaluated for inflammatory response.ResultsNo significant difference was found in terms of tissue reaction between the study and control groups. On day 7, randomly distributed brown-black granules were seen in the granulation tissue adjacent to the bracket in the study group. These foreign particles continued along the bracket cavity in a few samples, but the inflammatory response was insignificant between the groups. Mast cell count was found to be significantly smaller only on day 7 in the study group than in the control group.ConclusionsNanosilver-coated orthodontic brackets were found to be similar with the standard type concerning inflammation. Further researches are needed with regard to the assessment of the brown-black granules, especially on the deposition of the vessel walls.

Dextran-Coated Iron Oxide Nanoparticles as Biomimetic Catalysts for Localized and pH-Activated Biofilm Disruption

“…Recently, nanotechnology has gained attention for dental applications. [12][13][14][15][16][17][18][19] Zinc oxide 20 and silver [20][21][22][23] nanoparticles as well as iron oxide nanozymes (NZM) 12 have been proposed as antibiofilm agents. In particular, uncoated NZM displayed potent antibiofilm actions due to their high peroxidase-like catalytic activity in acidic environments, 12 which can disrupt caries development in the presence of low concentrations of H 2 O 2 .…”

Cytomorphometric analysis on the effects of components of orthodontic appliances on the epithelial cells of the buccal mucosa

“…Gamze in a study found a significantly lowered mast cell count and suggested that nanosilver-coated orthodontic brackets have better tissue compatibility than standard orthodontic brackets. [ 21 ] In the oral cavity, mitotic activity occurs in the basal layer of the epithelium, which is exfoliated into the oral cavity within 14 days. Hence, any genetic damage caused by continuous uptake of toxic ions released from the metal alloys or due to trauma in the mucosal cells can be reflected in the exfoliated cells as micronuclei, binucleated cell, broken egg, karyolysis, karyorrhexis, and pycknosis.…”

The Applications and the current status of silver nanoparticles in the field of Orthodontics

“…Addition of silver nanoparticles to the bonding system affected the shear bond strength of the orthodontic brackets to enamel. [9,11]. Sonja Blocher et al, demonstrated the addition of micro silver or AgNPs to an orthodontic primer which affected shear bond strength (SBS) and bracket/adhesive failure.…”