Biocompatibility of New Pulp-capping Materials NeoMTA Plus, MTA Repair HP, and Biodentine on Human Dental Pulp Stem Cells

Tomás-Catalá, Christopher J.; Collado-González, Mar; García‐Bernal, David; Sánchez, Ricardo Elías Oñate; Forner, Leopoldo; Llena, Carmen; Lozano, Adrián; Moraleda, José Marı́a; Rodríguez-Lozano, Francisco Javier

doi:10.1016/j.joen.2017.07.017

Cited by 119 publications

(133 citation statements)

References 31 publications

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“…Biodentine is a novel bioceramic calcium silicate-based cement that possesses biocompatible and noncytotoxic properties [22,27]. In one study, the highest migration rate of dental pulp stem cells was found in the Biodentine group, and scanning electron microscopy revealed superior cell adhesion on disks of Biodentine [22].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity and Mineralization Potential of Four Calcium Silicate-Based Cements on Human Gingiva-Derived Stem Cells

et al. 2020

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The aim of this study was to evaluate the cytotoxicity and mineralization potential of four calcium silicate-based cements on human gingiva-derived stem cells (GDSCs). The materials evaluated in the present study were ProRoot MTA (Dentsply Tulsa Dental Specialties), Biodentine (Septodont), Endocem Zr (Maruchi), and RetroMTA (BioMTA). Experimental disks of 6 mm in diameter and 3 mm in height were produced and placed in a 100% humidified atmosphere for 48 h to set. We evaluated the cytotoxic effects of the cements using methyl-thiazoldiphenyl-tetrazolium (MTT) and live/dead staining assays. We used a scratch wound healing assay to evaluate cell migratory ability. Mineralization potential was determined with an Alizarin red S (ARS) staining assay. In the MTT assay, no significant differences were found among the ProRoot MTA, Biodentine, and control groups during the test period (p > 0.05). The Endocem Zr and RetroMTA groups showed relatively lower cell viability than the control group at day 7 (p < 0.05). In the wound healing assay, no significant differences were found among the ProRoot MTA, Biodentine, Endocem Zr, and control groups during the test period (p > 0.05). The RetroMTA group had slower cell migration compared to the control group at days 3 and 4 (p < 0.05). In the ARS assay, the ProRoot MTA, Biodentine, and RetroMTA groups exhibited a significant increase in the formation of mineralized nodules compared to the Endocem Zr and control groups on day 21 (p < 0.05). In conclusion, the four calcium silicate-based cements evaluated in the present study exhibited good biological properties on GDSCs. ProRoot MTA, Biodentine, and RetroMTA showed higher mineralization potential than the Endocem Zr and control groups.

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity and Mineralization Potential of Four Calcium Silicate-Based Cements on Human Gingiva-Derived Stem Cells

et al. 2020

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“…Alternation in material characteristics has recently led to development of new generation MTA-based cements; namely, Neo MTA Plus (Avalon Biomed Inc., Houston, TX, USA) and the iRoot (Innovative BioCeramix Inc., Vancouver, BC, Canada) products family. Both materials share the same clinical applications in vital pulp treatment, but only a few studies are available to assess their use in clinical practice [89][90][91][92]. Neo MTA Plus was developed to be used in pulpotomies without the risk of discoloration due to elimination of bismuth oxide.…”

Section: Novel Mineral Trioxide Aggregate Restorative Cementsmentioning

confidence: 99%

Bio-Inductive Materials in Direct and Indirect Pulp Capping—A Review Article

2020

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The article is aimed at analyzing the available research and comparing the properties of bio-inductive materials in direct and indirect pulp capping procedures. The properties and clinical performances of four calcium-silicate cements (ProRoot MTA, MTA Angelus, RetroMTA, Biodentine), a light-cured calcium silicate-based material (TheraCal LC) and an enhanced resin-modified glass-ionomer (ACTIVA BioACTIVE) are widely discussed. A correlation of in vitro and in vivo data revealed that, currently, the most validated material for pulp capping procedures is still MTA. Despite Biodentine's superiority in relatively easier manipulation, competitive pricing and predictable clinical outcome, more long-term clinical studies on Biodentine as a pulp capping agent are needed. According to available research, there is also insufficient evidence to support the use of TheraCal LC or ACTIVA BioACTIVE BASE/LINER in vital pulp therapy.

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“…, Tomas‐Catala et al . ). They also promote reparative dentine formation, cementum formation and osteoblast differentiation (Koh et al .…”

Section: External Repair With or Without Endodontic Treatmentmentioning

confidence: 97%

“…An indirect or direct pulp cap using a bioactive endodontic cement such as Biodentine, (Biodentine TM Septodont, Saint-Maur-des-fosses, France) or MTA (ProRoot MTA, Dentsply Sirona Endodontics, Tulsa, OK, USA; MTA-Angelus, Angelus, Londrina-PR, Brazil) may be indicated if the pulp is close to being or is perforated, for example, Patel class 1Ap, 2Ap, 2Bp (Nair et al 2008, Nowicka et al 2013). These materials have excellent sealing ability , Koubi et al 2012, Raskin et al 2012, Ramezanali et al 2017, antibacterial properties ) and biocompatibility (Sultana et al 2018, Tomas-Catala et al 2018. They also promote reparative dentine formation, cementum formation and osteoblast differentiation (Koh et al 1997, Zanini et al 2012).…”

Section: External Repair With or Without Endodontic Treatmentmentioning

confidence: 99%

External cervical resorption: part 2 – management

et al. 2018

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Effective management of external cervical resorption (ECR) depends on accurate assessment of the true nature and accessibility of ECR; this has been discussed in part 1 of this 2 part article. This aim of this article was firstly, to review the literature in relation to the management of ECR and secondly, based on the available evidence, describe different strategies for the management of ECR. In cases where ECR is supracrestal, superficial and with limited circumferential spread, a surgical repair without root canal treatment is the preferred approach. With more extensive ECR lesions, vital pulp therapy or root canal treatment may also be indicated. Internal repair is indicated where there is limited resorptive damage to the external aspect of the tooth and/or where an external (surgical) approach is not possible due to the inaccessible nature of subcrestal ECR. In these cases, root canal treatment will also need to be carried out. Intentional reimplantation is indicated in cases where a surgical or internal approach is not practical. An atraumatic extraction technique and short extraoral period followed by 2-week splinting are important prognostic factors. Periodic reviews may be indicated in cases where active management is not pragmatic. Finally, extraction of the affected tooth may be the only option in untreatable cases where there are aesthetic, functional and/or symptomatic issues.

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Biocompatibility of New Pulp-capping Materials NeoMTA Plus, MTA Repair HP, and Biodentine on Human Dental Pulp Stem Cells

Abstract: The new pulp-capping materials MTA Repair HP, NeoMTA Plus, and Biodentine showed a suitable degree of cytocompatibility with hDPSCs, and good cell migration rates, although Biodentine showed higher rates of proliferation time-dependent.

Cited by 119 publications

References 31 publications

Cytotoxicity and Mineralization Potential of Four Calcium Silicate-Based Cements on Human Gingiva-Derived Stem Cells

Cytotoxicity and Mineralization Potential of Four Calcium Silicate-Based Cements on Human Gingiva-Derived Stem Cells

Bio-Inductive Materials in Direct and Indirect Pulp Capping—A Review Article

External cervical resorption: part 2 – management

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