Biocompatibility of Ni-free Zr-based bulk metallic glasses

Liu, L.; Qiu, Chen; Huang, Chensihan; Yu, Yang; Huang, Huiting; Zhang, S.M.

doi:10.1016/j.intermet.2008.07.022

Cited by 78 publications

(32 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 7(b) is the high magnification of one worn scar, from which one can see that a tribolayer with extensive distribution of microcracks was formed on the worn surface, and part of the tribolayer has already peeled out due to the propagation of the cracks. The composition analysis on the tribolayer by EDX revealed that the tribolayer contains a high concentration of O and Zr, as well as the elements of Al, Fe and Ti [34]. This indicates that the tribolayer is most likely composed of ZrO 2 mixed with other metal oxides.…”

Section: Friction Behavior Of the Ni-free Zr-based Bmgsmentioning

confidence: 95%

“…Ti-6Al-4V alloy was also tested in the same condition for comparison. Figure 6 shows the friction curves of Zr 60 Ti 6 Cu 19 Fe 5 Al 10 BMG and Ti-6Al-4V alloy [34]. It can be seen that the friction of the BMG is relatively smooth with very weak variation in friction coefficient, while the friction curve of Ti-6Al-4V is significantly quaky.…”

Section: Friction Behavior Of the Ni-free Zr-based Bmgsmentioning

confidence: 98%

“…To verify the potential for use as biomaterials of the Ni-free Zr-based BMGs, the mechanical properties of some BMGs developed in this work were examined by compressive testing using Zwick or TMS testing machine. Figure 4 shows the stress-strain (σ-ε) curves of some BMG samples (with aspect ratio of 1∶2) under a constant strain rate of 1Â10 -4 s -1 [27,34]. It can be seen that the BMGs tested exhibit not only high yield strength, but also significant plasticity.…”

Section: Mechanical Behavior Of the Ni-free Zr-based Bmgsmentioning

confidence: 99%

See 2 more Smart Citations

The potential of Zr-based bulk metallic glasses as biomaterials

Chen

Liu

Zhang

2010

Front. Mater. Sci. China

View full text Add to dashboard Cite

Zr-based bulk metallic glasses (BMGs) are a new type of metallic materials with disordered atomic structure that exhibit high strength and high elastic strain, relatively low Young's modulus, and excellent corrosion resistance and biocompatibility. The combination of these unique properties makes the Zr-based BMGs very promising for biomaterials applications. In this review article, the authors give an overview of the recent progress in the study of biocompatibility of Zr-based BMGs, especially the relevant work that has been done in the metallic glasses group in Huazhong University of Science and Technology (HUST), including the development of Ni-free Zr-based BMGs, the mechanical and wear properties, the bio-corrosion resistance, the in vitro and in vivo biocompatibility and the bioactive surface modification of these newly developed BMGs.

show abstract

Section: Friction Behavior Of the Ni-free Zr-based Bmgsmentioning

confidence: 95%

Section: Friction Behavior Of the Ni-free Zr-based Bmgsmentioning

confidence: 98%

Section: Mechanical Behavior Of the Ni-free Zr-based Bmgsmentioning

confidence: 99%

See 1 more Smart Citation

The potential of Zr-based bulk metallic glasses as biomaterials

Chen

Liu

Zhang

2010

Front. Mater. Sci. China

View full text Add to dashboard Cite

show abstract

“…The evaluation of the histocompatibility of the BMGs was conducted by implanting BMG samples into white rabbits subcutaneous, and it showed that the BMG implants performed as well as the Ti alloy. 61) Imai and Hiromoto 62) used intramedullary nails in rat femora to make in vivo assessment of the Zr 65 Al 7.5 Ni 10 Cu 17.5 BMGs. Compared with TiAl 6 V 4 alloy and 316L stainless steel, it showed lower levels of Cu and Ni in the blood and the surrounding soft tissue, and the intramedullary nails made of Zr-based BMG had no difference in promoting osteotomy healing time.…”

Section: Biocompatibilitymentioning

confidence: 99%

Potential Prospective Application of Zr-Based Bulk Metallic Glasses in Dental Implant

et al. 2015

View full text Add to dashboard Cite

Zr-based bulk metallic glasses (BMGs) are being studied widely in recent years due to their unique mechanical properties. In this paper, we will present the progress in the studies of corrosion resistance behavior and biomedical potential of the Zr-based BMGs, especially the in vitro and in vivo evaluation of their biocompatibility. Owing to their high resistance to corrosion in a physiological environment and the excellent biocompatibility that give them a passive, stable oxide film, Zr-based BMGs are considered the material of choice for intraosseous use. The aim of this paper is to give an overview of the available literature on the Zr-based BMGs and present a promising prospect for the application of oral implant.

show abstract

“…Major efforts have been made in removing Ni from the alloying elements, because Ni is a known allergen. Ni-free glass forming systems such as Zr-Al-Cu [7], Zr-Al-Co [8][9][10][11], Zr-Al-Co-Cu [12], Zr-Al-Fe-Cu [13], Zr-Cu-PdAl-Nb [14], Zr-(Cu, Ag)-Al [15], Zr-Al-Cu-Fe-(Ti/Nb) [16], and Zr-Al-Co-Ag [17,18] have been developed. Among the Ni-free Zr-based BMGs, Zr-Al-Co BMGs are attractive because they are free from copper, which may result in high cytotoxicity if excessive release occurs during corrosion and is also an element of concern in biomaterials [19].…”

mentioning

confidence: 99%

Formation and biocorrosion behavior of Zr-Al-Co-Nb bulk metallic glasses

Huang

Pang

et al. 2012

Chin. Sci. Bull.

View full text Add to dashboard Cite

Ni-and Cu-free Zr-Al-Co-Nb glassy alloys with different Nb and Co contents were synthesized by melt spinning and copper mold casting. The effects of Nb addition to partially replace Co in the Zr 55 Al 20 Co 25 glassy alloy on the glass-forming ability, thermal properties, in-vitro biocorrosion behavior and surface wettability of the metallic glasses were investigated. Although addition of Nb up to 5 at.% slightly decreased the supercooled liquid region and the glass-forming ability (GFA), the alloys could be casted in a bulk glassy rod form with diameters up to 3 mm. The Zr-Al-Co-Nb glassy alloys were spontaneously passivated with low passive current densities in phosphate buffered saline and Hanks' solution. Substitution of "toxic" Co by Nb is effective in improved the corrosion resistance of the Zr-Al-Co glassy alloy. Water contact angle measurements showed that Nb addition increased the hydrophilicity of the glassy alloys, which may enhance cell adhesion of the alloys in biomedical applications. Because of the lack of long-range atomic order, Zr-based bulk metallic glasses (BMGs) exhibit superior strength, high elastic strain limits and fatigue endurance limits, relatively low Young's modulus, and excellent wear and corrosion resistance [1][2][3][4][5], which attracted attention in biomedical applications. However, toxic elements such as nickel and copper are often included in Zr-based metallic glasses to achieve high glass-forming ability (GFA), which are thought to impair cellular metabolism [6]. In recent years, many efforts have been made to remove these elements from Zr-based BMGs to further improve their biocompatibility. (x = 2.5 at.% and 5 at.%) metallic glasses have been developed, and addition of Nb were found to enhance their resistance to pitting corrosion in 3 mass% NaCl solution [20]. From the viewpoint of biomedical engineering, Nb is recognized as a highly biocompatible element. In the quaternary Zr-Al-Co-Nb alloys, Co is more cytotoxic than Al, and excessive amounts of Co or prolonged exposure to Co may result in Co poisoning [21][22][23]. Therefore, rather than substitution of Al with Nb as in the previous study [20], substitution of Co with Nb could further improve the biocompatibility of the alloys. In consideration of potential medical applications, the GFA and in vitro biocorrosion behavior of Zr 55 Al 20 Co 25x Nb x glassy alloys were investigated in the present work. Surface wettability of the

show abstract

Biocompatibility of Ni-free Zr-based bulk metallic glasses

Cited by 78 publications

References 17 publications

The potential of Zr-based bulk metallic glasses as biomaterials

The potential of Zr-based bulk metallic glasses as biomaterials

Potential Prospective Application of Zr-Based Bulk Metallic Glasses in Dental Implant

Formation and biocorrosion behavior of Zr-Al-Co-Nb bulk metallic glasses

Contact Info

Product

Resources

About