Biocompatibility of Polyacrylamide Microcapsules Implanted in Peritoneal Cavity or Spleen of the Rat. Effect on Various Inflammatory Reactions in Vitro

Gin, H.; Dupuy, B.; Bonnemaison-Bourignon, D.; Bordenave, Laurence; Bareille, Reine; Latapie, M. J.; Baquey, C.; Bezian, J. H.; Ducassou, D.

doi:10.3109/10731199009117287

Cited by 27 publications

(13 citation statements)

References 16 publications

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“…In this manuscript, omentum activation was carried out by injection of polyacrylamide beads. Polyacrylamide microcapsule has been tested for biocompatibility and was found mildly inflammatory but did not provoke significant proliferation of immune cells [67]. Polyacrylamide gel was initially infiltrated by macrophage and slow integrated within its host tissue via a thin fibrous network [68].…”

Section: Discussionmentioning

confidence: 99%

Cellular Basis of Tissue Regeneration by Omentum

et al. 2012

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The omentum is a sheet-like tissue attached to the greater curvature of the stomach and contains secondary lymphoid organs called milky spots. The omentum has been used for its healing potential for over 100 years by transposing the omental pedicle to injured organs (omental transposition), but the mechanism by which omentum helps the healing process of damaged tissues is not well understood. Omental transposition promotes expansion of pancreatic islets, hepatocytes, embryonic kidney, and neurons. Omental cells (OCs) can be activated by foreign bodies in vivo. Once activated, they become a rich source for growth factors and express pluripotent stem cell markers. Moreover, OCs become engrafted in injured tissues suggesting that they might function as stem cells.Omentum consists of a variety of phenotypically and functionally distinctive cells. To understand the mechanism of tissue repair support by the omentum in more detail, we analyzed the cell subsets derived from the omentum on immune and inflammatory responses. Our data demonstrate that the omentum contains at least two groups of cells that support tissue repair, immunomodulatory myeloid derived suppressor cells and omnipotent stem cells that are indistinguishable from mesenchymal stem cells. Based on these data, we propose that the omentum is a designated organ for tissue repair and healing in response to foreign invasion and tissue damage.

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Section: Discussionmentioning

confidence: 99%

Cellular Basis of Tissue Regeneration by Omentum

et al. 2012

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“…The low gel/water interfacial tension minimizes protein adsorption and cellular adhesion and proliferation. This was further proved by the fact that, in vitro, the surface of the polyAC gel is a poor support for attachment and growth of human fibroblast (14).…”

Section: Introductionmentioning

confidence: 82%

Preparation and Release of Ibuprofen from Polyacrylamide Gels

Hussain

Rogers

Mehvar

et al. 1999

Drug Development and Industrial Pharmacy

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The conditions of preparation of polyacrylamide (polyAC) gels, the incorporation of ibuprofen (IB), and the kinetics of IB release under various conditions have been evaluated. Transparent, opaque, or elastic gels were prepared depending on the concentration of acrylamide (AC) and the cross-linking agent, N,N'-methylenebisacrylamide (BIS). Release studies in media below pH 5.0 resulted in opaque gels. The kinetics of IB release was a function of the AC, BIS, and the pH of the medium, but the optimum composition, in terms of gel integrity and release characteristics, was 7% AC cross-linked with BIS at a 50:1 ratio. Modulation of the release rate was possible with the incorporation of 10% of certain polymers. The amount of IB that could be incorporated per gram of transparent gel was a function of the amount of polymer initiator N,N,N',N'-tetramethylene diamine (TEMED) used per gram of gel. More than 200 mg of IB could be incorporated per gram of transparent gel by using 100 microliters of TEMED. The release of IB obeyed matrix/swelling-controlled kinetics and 70-80% of the IB was released from gels containing 10 to 40 mg IB per gram of gel in 5 hr at pH 7.4 and 37 degrees C.

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“…[167][168][169] Dennoch gibt es Berichte zu Entzün-dungsreaktionen nach der Implantation von PAAm-Hydrogelen. [170][171][172] Außer diesen medizinischen Nachteilen sprechen auch andere Eigenschaften gegen die Verwendung von PAAm für Wirkstoff-Transportsysteme: 1) PAAm kann sowohl durch thermische als auch durch photolytische Einwirkungen zu Acrylamid abgebaut werden; [171] 2) es hat ein Kohlenstoffrückgrat, sodass es nicht biologisch abgebaut werden kann; [171] 3) 7-kDa-PAAm-modifizierte Liposomen verteilen sich bevorzugt in die Leber; [163] 4) PAAm wird aus Acrylamid synthetisiert, das schwere neurotoxische Schäden hervorrufen kann. [171,173] Angesichts seiner Nachteile überrascht die breite Anwendung von PAAm.…”

Section: Wirkstoff-transportunclassified

Anwendung von Poly(ethylenglycol) beim Wirkstoff‐Transport: Vorteile, Nachteile und Alternativen

et al. 2010

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Im stetig wachsenden Feld der Polymer‐basierten Wirkstoff‐Transport‐Systeme gilt Poly(ethylenglycol) (PEG) als der Goldstandard für Stealth‐Polymere. Welche Eigenschaften PEG aufweist, die diese herausragende Stellung rechtfertigen, soll in diesem Aufsatz diskutiert werden. Die ersten PEGylierten Produkte erschienen bereits vor 20 Jahren auf dem Markt. Seither konnten viele Erkenntnisse in klinischen Untersuchungen gewonnen werden, allerdings wurden dabei nicht nur Vorteile festgestellt, sondern auch mögliche Nebenwirkungen und Komplikationen bei der Anwendung aufgedeckt. Diese möglichen Nachteile, die eine tiefergehende Untersuchung erfordern, können in folgende Kategorien unterteilt werden: Hypersensitivität, Veränderungen der Pharmakokinetik, toxische Nebenprodukte sowie ein Abbauparadoxon, das aus der Etherstruktur resultiert: Einerseits kann das Polymer relativ einfach unter mechanischer Belastung abgebaut werden, andererseits wird jedoch ein biologischer Abbau verhindert, was bei In‐vivo‐Anwendungen zur Anreicherung im Körper führen kann. Der Aufsatz diskutiert diese möglichen Nachteile und stellt alternative Polymere vor.

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Biocompatibility of Polyacrylamide Microcapsules Implanted in Peritoneal Cavity or Spleen of the Rat. Effect on Various Inflammatory Reactions in Vitro

Cited by 27 publications

References 16 publications

Cellular Basis of Tissue Regeneration by Omentum

Cellular Basis of Tissue Regeneration by Omentum

Preparation and Release of Ibuprofen from Polyacrylamide Gels

Anwendung von Poly(ethylenglycol) beim Wirkstoff‐Transport: Vorteile, Nachteile und Alternativen

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