Biocompatibility of polypyrrole particles: an in-vivo study in mice

Ramanavičienė, Almira; Kaušaitė, Asta; Tautkus, Stasys

doi:10.1211/jpp.59.2.0017

Cited by 277 publications

(135 citation statements)

References 24 publications

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“…They include polyacetylene, polyaniline, polypyrrole (PPy), polythiophene, poly(3,4-ethylenedioxythiophene) (PEDOT), and their derivatives. PPy has been studied most extensively for biomedical applications due to its biocompatibility and electrical properties (Ateh et al, 2006;Ramanaviciene et al, 2007). PEDOT has been used for biomedical applications because of its chemical stability and conductivity (Cui and Martin, 2003;Kros et al, 2005).…”

Section: Conducting Polymer Electrode Coatingsmentioning

confidence: 99%

Localized cell and drug delivery for auditory prostheses

et al. 2008

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Localized cell and drug delivery to the cochlea and central auditory pathway can improve the safety and performance of implanted auditory prostheses (APs). While generally successful, these devices have a number of limitations and adverse effects including limited tonal and dynamic ranges, channel interactions, unwanted stimulation of non-auditory nerves, immune rejection, and infections including meningitis. Many of these limitations are associated with the tissue reactions to implanted auditory prosthetic devices and the gradual degeneration of the auditory system following deafness. Strategies to reduce the insertion trauma, degeneration of target neurons, fibrous and bony tissue encapsulation, and immune activation can improve the viability of tissue required for AP function as well as improve the resolution of stimulation for reduced channel interaction and improved place-pitch and level discrimination. Many pharmaceutical compounds have been identified that promote the viability of auditory tissue and prevent inflammation and infection. Cell delivery and gene therapy have provided promising results for treating hearing loss and reversing degeneration. Currently, many clinical and experimental methods can produce extremely localized and sustained drug delivery to address AP limitations. These methods provide better control over drug concentrations while eliminating the adverse effects of systemic delivery. Many of these drug delivery techniques can be integrated into modern auditory prosthetic devices to optimize the tissue response to the implanted device and reduce the risk of infection or rejection. Together, these methods and pharmaceutical agents can be used to optimize the tissue-device interface for improved AP safety and effectiveness.

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Section: Conducting Polymer Electrode Coatingsmentioning

confidence: 99%

Localized cell and drug delivery for auditory prostheses

et al. 2008

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“…The major reason for the focus on use of this particular conducting polymer, in addition to ease of synthesis, processability in aqueous solutions and high conductivity, is largely due to the cytocompatibility of PPy (Fonner et al 2008;George et al 2005;Ramanaviciene et al 2007;Wang et al 2004a;Zhang et al 2001) and its ability to promote cell adhesion (Lee and Schmidt 2014;Molino et al 2013;Thompson et al 2011;Zhang et al 2014).…”

Section: Introductionmentioning

confidence: 99%

From nanoparticles to fibres: effect of dispersion composition on fibre properties

et al. 2015

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A polyvinyl alcohol (PVA)-stabilized polypyrrole nanodispersion has been optimised for conductivity and processability by decreasing the quantity of PVA before and after synthesis. A reduction of PVA before synthesis leads to the formation of particles with a slight increase in dry particle diameter (51 ± 6 to 63 ± 3 nm), and conversely a reduced hydrodynamic diameter. Conductivity of the dried nanoparticle films was not measureable after a reduction of PVA prior to synthesis. Using filtration of particles after synthesis, PVA content was sufficiently reduced to achieve dried thin film conductivity of 2 S cm -1 , while the electroactivity of the dispersed particles remained unchanged. The as-synthesized and PVA-reduced polypyrrole particles were successfully spun into allnanoparticle fibres using a wet-extrusion approach without the addition of any polymer or gel matrix. Using nanoparticles as a starting material is a novel approach, which allowed the production of macroscale fibres that consisted entirely of polypyrrole nanoparticles. Fibres made from PVA-reduced polypyrrole showed higher electroactivity compared to fibres composed of the dispersion high in PVA. The mechanical properties of the fibres were also improved by reducing the amount of PVA present, resulting in a stronger, more ductile and less brittle fibre, which could find potential application in various fields.

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“…Most importantly, all these processing steps may be performed in batch or continuous mode, in bio-benign aqueous environments at pH values close to 7.0 and with the use of modest electrode potentials under conditions that are close to ambient; conditions that are compatible with biological recognition entities and that prevent denaturation. Thus, conducting electroactive polymers (CEPs) have many attractive features such as selectivity of enzyme entrapment to electrode surfaces [26,27], reduction of interfacial impedance, thickness control via charge density [28], enzyme stability, biocompatibility [29][30][31], and adjustment of biosensor enzyme kinetic properties. Polypyrrole, along with other electroactive polymers, once formed, can be surface modified and used for various chemical coupling reactions [32,33].…”

Section: Introductionmentioning

confidence: 99%

Biofabrication Using Pyrrole Electropolymerization for the Immobilization of Glucose Oxidase and Lactate Oxidase on Implanted Microfabricated Biotransducers

2014

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Abstract:The dual responsive Electrochemical Cell-on-a-Chip Microdisc Electrode Array (ECC MDEA 5037) is a recently developed electrochemical transducer for use in a wireless, implantable biosensor system for the continuous measurement of interstitial glucose and lactate. Fabrication of the biorecognition membrane via pyrrole electropolymerization and both in vitro and in vivo characterization of the resulting biotransducer is described. The influence of EDC-NHS covalent conjugation of glucose oxidase with 4-(3-pyrrolyl) butyric acid (monomerization) and with 4-sulfobenzoic acid (sulfonization) on biosensor performance was examined. As the extent of enzyme conjugation was increased sensitivity decreased for monomerized enzymes but increased for sulfonized enzymes. Implanted biotransducers were examined in a Sprague-Dawley rat hemorrhage model. Resection after 4 h and subsequent in vitro re-characterization showed a decreased sensitivity from OPEN ACCESSBioengineering 2014, 1 86 0.68 (±0.40) to 0.22 (±0.17) µA ·cm −2 ·mM −1 , an increase in the limit of detection from 0.05 (±0.03) to 0.27 (±0.27) mM and a six-fold increase in the response time from 41 (±18) to 244 (±193) s. This evidence reconfirms the importance of biofouling at the bio-abio interface and the need for mitigation strategies to address the foreign body response.

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Biocompatibility of polypyrrole particles: an in-vivo study in mice

Cited by 277 publications

References 24 publications

Localized cell and drug delivery for auditory prostheses

Localized cell and drug delivery for auditory prostheses

From nanoparticles to fibres: effect of dispersion composition on fibre properties

Biofabrication Using Pyrrole Electropolymerization for the Immobilization of Glucose Oxidase and Lactate Oxidase on Implanted Microfabricated Biotransducers

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