2013
DOI: 10.3171/2013.1.peds12374
|View full text |Cite
|
Sign up to set email alerts
|

Biocompatibility of pristine graphene for neuronal interface

Abstract: Object Graphene possesses unique electrical, physical, and chemical properties that may offer significant potential as a bioscaffold for neuronal regeneration after spinal cord injury. The purpose of this investigation was to establish the in vitro biocompatibility of pristine graphene for interface with primary rat cortical neurons. Methods Graphene films were prepared by chemical vapor deposition on a … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

3
77
0

Year Published

2014
2014
2021
2021

Publication Types

Select...
10

Relationship

1
9

Authors

Journals

citations
Cited by 86 publications
(80 citation statements)
references
References 51 publications
3
77
0
Order By: Relevance
“…23 This is related to the differences in the intrinsic physical-chemical properties of the different sources and forms of graphene used in the studies. 35,36 Graphene-based materials (e.g., pristine graphene, graphene oxide, reduced graphene oxide, or composites thereof) have been shown to exhibit good compatibility with mammalian cells or cell lines. 29,35,37,38 Our work has demonstrated for the first time that freestanding films of graphene and G-foam facilitated corneal stromal fibroblast attachment and proliferation and showed no adverse reactions in short-term implantation into rabbit corneas, thus indicating the potential usage of graphene as a component of artificial cornea devices.…”
Section: Discussionmentioning
confidence: 99%
“…23 This is related to the differences in the intrinsic physical-chemical properties of the different sources and forms of graphene used in the studies. 35,36 Graphene-based materials (e.g., pristine graphene, graphene oxide, reduced graphene oxide, or composites thereof) have been shown to exhibit good compatibility with mammalian cells or cell lines. 29,35,37,38 Our work has demonstrated for the first time that freestanding films of graphene and G-foam facilitated corneal stromal fibroblast attachment and proliferation and showed no adverse reactions in short-term implantation into rabbit corneas, thus indicating the potential usage of graphene as a component of artificial cornea devices.…”
Section: Discussionmentioning
confidence: 99%
“…Graphene devices also have low electronic noise, leading to sensor technologies with unprecedented sensitivities, enabling detection of individual molecules 25,26 . Promising results for graphene biocompatibility increase its potential use in biomedical applications 2730 as well. Different from other transparent conducting materials, graphene uniquely combines flexibility, low noise, and protection against corrosion 31,32 in one single material system.…”
Section: Introductionmentioning
confidence: 99%
“…Sahni et al [139] compared the neurite outgrowth of rat primary cortical neurons cultured on bare, graphene- and poly-D-lysine (PDL)-coated plastic polymer dishes, and found that neuronal viability showed remarkable differences between graphene and PDL substrates; the morphology of cells cultured on graphene displayed more linear dendritic structures compared to cells cultured on PDL and in control conditions. The improved neuronal adhesion on graphene, compared to the bare plastic polymeric dish, was ascribed by the authors to van der Waals forces between cell membranes and graphene.…”
Section: Reviewmentioning
confidence: 99%