Biocompatibility of pure iron: In vitro assessment of degradation kinetics and cytotoxicity on endothelial cells

Zhu, Shengfa; Huang, Nan; Xu, Liyun; Liu, Hengquan; Sun, Hongqi; Leng, Y.X.

doi:10.1016/j.msec.2008.12.019

Cited by 162 publications

(104 citation statements)

References 8 publications

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“…During in vitro tests a layer of precipitated degradation products forms, which usually exhibits a brownish color and consists of hydroxides originating from the reactions above [71,72].…”

Section: Degradation Mechanismmentioning

confidence: 99%

An In Vitro Corrosion Study of Open Cell Iron Structures with PEG Coating for Bone Replacement Applications

Haverová

Oriňáková

Oriňák

et al. 2018

Metals

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Abstract:Iron-based substrates with polyethylene glycol coating were prepared as possible materials for biodegradable orthopedic implants. Biodegradable materials that provide mechanical support of the diseased tissue at the time of implanting and then disappear gradually during the healing process are sometimes favored instead of permanent implants. The implant degradation rate should match the time of the tissue regrowth. In this work, the degradation behavior of iron-based foams was studied electrochemically during immersion tests in Hanks' solution. The corrosion rate of the polyethylene glycol-coated samples increased and the corrosion potential shifted to more negative values. This indicates an enhanced degradation rate as compared to the uncoated material, fulfilling the goal of being able to tune the degradation rate. It is the interfacial interaction between the hydrophilic polymer layer and the iron surface that is responsible for the enhanced oxidation rate of iron.

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“…During in vitro tests a layer of precipitated degradation products forms, which usually exhibits a brownish color and consists of hydroxides originating from the reactions above [71,72].…”

Section: Degradation Mechanismmentioning

confidence: 99%

An In Vitro Corrosion Study of Open Cell Iron Structures with PEG Coating for Bone Replacement Applications

Haverová

Oriňáková

Oriňák

et al. 2018

Metals

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“…The average weight loss of the specimen in 40 mL SBF solution was 17.15×10 −5 g cm -2 day −1 , so the 25% of the 24 h immersion is 0.0429 mg mL −1 . Zhu et al [31] reported that approximately a release of 0.05 mg mL −1 Fe ion is considered safe for the human body. Therefore, our results suggest that the concentration of Fe ions released from the specimen is within the safety level.…”

Section: Tensilementioning

confidence: 99%

Mechanical and corrosion properties of partially degradable bone screws made of pure iron and stainless steel 316L by friction welding

et al. 2017

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“…However, the mechanical properties of such alloys, i.e., strength and the elongation to fracture are not always acceptable which combined to the development of signiicant quantities of hydrogen limits their widespread use. Some studies [53][54][55] have reported as alternative solution the use of Fe-based alloys. However, the implants realized using such alloys reveal some reactions like those developed in longterm uses which is predominantly due to the low-degradation rate of pure Fe in biological atmosphere [56].…”

Section: Outlinementioning

confidence: 99%

Up-to-Date Knowledge and Outlooks for the Use of Metallic Biomaterials: Review Paper

Peter¹,

Matekovits²,

Rosso³

2018

Biomaterials in Regenerative Medicine

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In all cases, when a material has to be used in medical applications, the knowledge of its physical, chemical and biological properties is of fundamental signiicance, since the direct contact between the biological system and the considered device could generate reactions whose long-term efects must be clearly quantiied. The class of materials that exhibits characteristics that allow their use for the considered applications are commonly called biomaterials. Patients sufering from diferent diseases generate a great demand for real therapies, where the use of biomaterials are mandatory. Commonly, metallic biomaterials are used because their structural functions; the high strength and resistance to fracture they can ofer, provide reliable performance primarily in the ields of orthopedics and dentistry.In metals, because of their particular structure, plastic deformation takes place easier, inducing good formability in manufacturing. The present paper is not encyclopaedic, but reports in the irst part some current literature data and perspectives about the possibility of use diferent class of metallic materials for medical applications, while the second part recalls some results of the current research in this ield carried out by the authors.

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Biocompatibility of pure iron: In vitro assessment of degradation kinetics and cytotoxicity on endothelial cells

Cited by 162 publications

References 8 publications

An In Vitro Corrosion Study of Open Cell Iron Structures with PEG Coating for Bone Replacement Applications

An In Vitro Corrosion Study of Open Cell Iron Structures with PEG Coating for Bone Replacement Applications

Mechanical and corrosion properties of partially degradable bone screws made of pure iron and stainless steel 316L by friction welding

Up-to-Date Knowledge and Outlooks for the Use of Metallic Biomaterials: Review Paper

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