Biocompatibility of SU-8 and Its Biomedical Device Applications

Chen, Ziyu; Lee, Jeong

doi:10.3390/mi12070794

Cited by 42 publications

(28 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study provides a comprehensive understanding of bacterial−SU-8 surface interaction, which could help design effective strategies for the fabrication of SU-8based various unique devices for biomedical applications. [6][7][8][9]12 ■ CONCLUSIONS In summary, our study elucidates the surface changes of SU-8 thin films governed by wettability and surface carboxylic groups and how such properties influence bacterial motility, adhesion, and subsequent colonization in a spatiotemporal manner. The enhancement of the motility and direction of X. fastidiosa single cells on carboxylated surfaces during the initial stages of growth has been observed.…”

Section: ■ Results and Discussionmentioning

confidence: 96%

Physiochemically Distinct Surface Properties of SU-8 Polymer Modulate Bacterial Cell-Surface Holdfast and Colonization

Anbumani

Silva

Alaferdov

et al. 2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

SU-8 polymer is an excellent platform for diverse applications due to its high aspect ratio of micro/nanostructure fabrication and exceptional physicochemical and biocompatible properties. Although SU-8 polymer has often been investigated for various biological applications, how its surface properties influence the interaction of bacterial cells with the substrate and its colonization is poorly understood. In this work, we tailor SU-8 nanoscale surface properties to investigate single-cell motility, adhesion, and successive colonization of phytopathogenic bacteria, Xylella fastidiosa. Different surface properties of SU-8 thin films have been prepared using photolithography processing and oxygen plasma treatment. A more significant density of carboxyl groups in hydrophilic plasma-treated SU-8 surfaces promotes faster cell motility in the earlier growth stage. The hydrophobic nature of pristine SU-8 surfaces shows no trackable bacterial motility and 5–10 times more single cells adhered to the surface than its plasma-treated counterpart. In addition, plasma-treated SU-8 samples suppressed bacterial adhesion, with surfaces showing less than 5% coverage. These results not only showcase that SU-8 surface properties can impact the spatiotemporal bacterial behavior but also provide insights into pathogens’ prominent ability to evolve and adapt to different surface properties.

show abstract

Section: ■ Results and Discussionmentioning

confidence: 96%

Physiochemically Distinct Surface Properties of SU-8 Polymer Modulate Bacterial Cell-Surface Holdfast and Colonization

Anbumani

Silva

Alaferdov

et al. 2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

“…It is known that the water contact angle affects the biocompatibility and the lower the water contact angle, the higher the biocompatibility. 43,44 It was analyzed that the water contact angles of MNs, Dox MNs, and Chi/Dox MNs surfaces with hydrophilic surfaces were 80.66 ± 1.08 , 55.35 ± 0.22 and 45.16 ± 0.19 , respectively (Table 1). Thus, it is observed that the contact angle of Chi/Dox MNs is successfully reduced compared to MNs and Dox/MNs samples.…”

Section: Resultsmentioning

confidence: 99%

Fabrication and characterization of innovative chitosan/doxorubicin coated3Dprinted microneedle patch for prolonged drug delivery

Camcı

Türk

Gepek

et al. 2022

J of Applied Polymer Sci

View full text Add to dashboard Cite

In this study, microneedles (MNs) were successfully fabricated using the 3D printing method, which provides ease of production and reproduction in the desired size. Chi/Dox MNs drug delivery systems containing doxorubicin (Dox) were successfully produced in the presence of glutaraldehyde, which was coated with chitosan (Chi) and used as a crosslinker to prolong the drug release of the produced MNs. The obtained Chi/Dox MNs drug distribution systems were characterized by SEM, FTIR, zeta, contact angle, surface energy, compression test, and drug release tests. With the SEM analyzes performed before and after coating, it was observed that the MNs were in micro dimensions, and the diameters of the MNs tips before and after coating were 41.22 μm and 54.58 μm, respectively. After the compression test, it was analyzed that each MNs could withstand a force of about 76 N. The zeta potentials of Chi and Dox solutions were measured as 8.8 and 21.5 mV, respectively. FTIR, zeta potential, contact angle, and surface energy results confirm the Dox coating and their interactions. It has been observed that Chi/Dox MNs has successfully extended drug release time without drug-burst, and their use in skin cancer treatment is promising.

show abstract

“…The 16-channel MEA uses SU-8 as the insulating substrate and Pt as the conductive material. SU-8 has been extensively utilized in biomedical devices due to its high transparency, low young's modulus, and high yield strength [54][55][56]. Pt is a common material for stimulation electrodes for its chemical inertness [57][58][59].…”

Section: Resultsmentioning

confidence: 99%

Integration of microprism and microelectrode arrays enables simultaneous electrophysiology and two-photon imaging across all cortical layers

Yang

Castagnola

et al. 2022

Preprint

View full text Add to dashboard Cite

Implantable microelectrode arrays (MEAs) have been widely used for multisite neural recording and stimulation in basic neurophysiological research and brain-computer interface (BCI) applications. However, exactly how neural electrodes interact with brain cells remains poorly understood. Two-photon microscopy (TPM) is a valuable tool to observe cellular activities in vivo, but the imaging depth is usually limited to the superficial brain regions. In this work, we build a multi-functional device by integrating a microprism with a custom-designed transparent MEA, allowing long-term sub-cellular imaging, electrophysiological recording, and microstimulation in the same region across all cortical layers. The accessible depth is about six times deeper than the conventional method (~1000 μm vs. ~150 μm). By implanting this device in Thy1-GCaMP6s mice, we obtained stable TPM images of neuronal calcium activities across multiple cortical layers near the MEA, as well as single-unit recordings for 16 weeks. For the first time, we visualized the neuronal network activation pattern of all cortical layers in response to electrical stimulation with TPM, demonstrating the influence of stimulation location, amplitude, and frequency on neuronal activity. This novel MEA-on-microprism design provides a powerful multimodal method to investigate electrophysiology and cellular activities throughout all cortical layers in living animals.

show abstract

Biocompatibility of SU-8 and Its Biomedical Device Applications

Cited by 42 publications

References 76 publications

Physiochemically Distinct Surface Properties of SU-8 Polymer Modulate Bacterial Cell-Surface Holdfast and Colonization

Physiochemically Distinct Surface Properties of SU-8 Polymer Modulate Bacterial Cell-Surface Holdfast and Colonization

Fabrication and characterization of innovative chitosan/doxorubicin coated3Dprinted microneedle patch for prolonged drug delivery

Integration of microprism and microelectrode arrays enables simultaneous electrophysiology and two-photon imaging across all cortical layers

Contact Info

Product

Resources

About