Biocompatibility of trillium biopassive surface–coated oxygenator versus uncoated oxygenator during cardiopulmonary bypass

Ereth, Mark H.; Nuttall, Gregory A.; Clarke, Suzanne; Dearani, Joseph A.; Fiechtner, Bridget K.; Rishavy, Cynthia R.; Buda, Daniel A.; Shaw, Trudy A.; Orszulak, Thomas A.; Oliver, William C.

doi:10.1053/jcan.2001.26525

Cited by 26 publications

(15 citation statements)

References 19 publications

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“…15,16 Our results showed better results in IL-6 and C3a levels and weak superiority in WBC and platelet counts.…”

Section: Discussionmentioning

confidence: 61%

Clinical significance of coated extracorporeal circuits: a review of novel technologies

Günaydın

2004

Perfusion

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Coating of extracorporeal circuits may be a solution to prevent adverse effects induced by the contact of blood elements and proteins with foreign surfaces. This paper reviews the recent novel coating technologies and compares their documented in vitro and ex vivo advantages under the clinical setting. Data presented have also been supported by postclinical biomaterial research to verify biocompatibility and hemocompatibility.

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“…15,16 Our results showed better results in IL-6 and C3a levels and weak superiority in WBC and platelet counts.…”

Section: Discussionmentioning

confidence: 61%

Clinical significance of coated extracorporeal circuits: a review of novel technologies

Günaydın

2004

Perfusion

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“…This is also in agreement with earlier studies. 31,35 The differences were not significant, even if the median concentrations were higher in the Trillium group. Due to the small Comparison of a bypass circuit and an oxygenator during surgery TN Hoel et al…”

Section: Coagulation and Fibrinolysismentioning

confidence: 80%

“…This is in agreement with some previous reports. 31,35 Plasmin formation, giving evidence of fibrinolytic activity and representing a marker for activation of the coagulation, showed a steady increase in both groups. This is also in agreement with earlier studies.…”

Section: Coagulation and Fibrinolysismentioning

confidence: 98%

Comparison of a Duraflo II-coated cardiopulmonary bypass circuit and a trillium-coated oxygenator during open-heart surgery

et al. 2004

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“…Thus, they limit coagulation at the artificial surface, at surgical sites, and within native blood vessels. The result is longer device lifespan but also increased risk of bleeding complications [3 – 5]. …”

Section: Introductionmentioning

confidence: 99%

Nitric Oxide-Generating Silicone As a Blood-Contacting Biomaterial

Amoako

Cook

2011

ASAIO Journal

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Coagulation upon blood-contacting biomaterials remains a problem for short and long-term clinical applications. This study examined the ability of copper(II)-doped silicone surfaces to generate nitric oxide (NO) and locally inhibit coagulation. Silicone was doped with 3-micron copper (Cu(0)) particles yielding 3 to 10 weight percent (wt%) Cu in 70-μm thick Cu/Silicone polymeric matrix composites (Cu/Si PMCs). At 3, 5, 8 and 10 wt% Cu doping, the surface expression of Cu was 12.1 ± 2.8%, 19.7 ± 5.4%, 29.0 ± 3.8%, and 33.8 ± 6.5% respectively. After oxidizing Cu(0) to Cu(II) by spontaneous corrosion, NO flux, JNO (mol*cm−2*min−1), as measured by chemiluminescence, increased with surface Cu expression according to the relationship JNO =(1.63 %SACu −0.81) ×10−11, R2 = 0.98 where %SACu is the percentage of surface occupied by Cu. NO flux at 10 wt% Cu was 5.35± 0.74 ×10−10 mol*cm−2*min−1. The clotting time of sheep blood exposed to these surfaces was 80 ± 13s with pure silicone and 339 ± 44s when 10 wt% Cu(II) was added. SEMs of coatings showed clots occurred away from exposed Cu-dendrites. In conclusion, Cu/Si PMCs inhibit coagulation in a dose-dependent fashion related to the extent of copper exposure on the coated surface.

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Biocompatibility of trillium biopassive surface–coated oxygenator versus uncoated oxygenator during cardiopulmonary bypass

Cited by 26 publications

References 19 publications

Clinical significance of coated extracorporeal circuits: a review of novel technologies

Clinical significance of coated extracorporeal circuits: a review of novel technologies

Comparison of a Duraflo II-coated cardiopulmonary bypass circuit and a trillium-coated oxygenator during open-heart surgery

Nitric Oxide-Generating Silicone As a Blood-Contacting Biomaterial

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