Biocompatibility of Two Novel Dermal Fillers: Histological Evaluation of Implants of a Hyaluronic Acid Filler and a Polyacrylamide Filler

Abstract

This study reveals that two soft-tissue fillers considered to be biocompatible induce very different tissue reactions. This indicates that their behavior in clinical practice is likely to be different.

Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI

“…Cross-linked hyaluronic acid (HA) derivatives are non-permanent dermal fillers used not only for the correction of HIV-LA, but also for treatment of photodamaged skin [13], facial atrophic scars [14] and other cosmetic purposes [15,16,17]. Histologic analyses of the forearm, buttock and iliac crest skin injected with different types of cross-linked HA have shown that HA implants have the ability to bind water and thereby provide volume and support to the injected tissue for up to 12 months without causing fibrosis or foreign body reactions [18,19,20,21]. Recent studies suggest that these fillers may stimulate dermal collagen anabolism by inducing increased procollagen and tissue inhibitor of matrix-degrading metalloproteinases (TIMP-1) levels [13,22].…”

Polyacrylamide soft tissue filler nodule mimicking a mucoepidermoid carcinoma

“…After injection, a fibrocellular capsule is formed. After 6-9 months the gel is dispersed into the skin and is surrounded by macrophages and fibroblasts 7,8 . Injected in medium or larger quantities, as for breast augmentation, a cellular foreign body reaction may occur 6 .…”

Regenerative and innovative joint medication in the horse – Part 2: Efficacy and adverse effects of joint medication in the horse - A review of the literature - The pathogenesis of osteoarthritis in the horse

“…Es wird beim Menschen seit einigen Jahren zur Unterstützung von subkutanem Gewebe, sowie zur Therapie der stressbedingten Inkontinenz der Frau eingesetzt (Lose et al 2006, Pallua und Wolters 2010. Humanmedizinische Studien zeigen eine gute Gewebeverträglichkeit und einen lang anhaltenden Effekt, da die Substanz in das Weichteilgewebe integriert werden soll (Fer-nández-Cossio und Castano-Oreja 2006, Christensen et al 2003, Christensen et al 2008, Bello et al 2007 …”