Biocompatibility of xenogeneic bone, commercially available coral, a bioceramic and tissue sealant for human osteoblasts

Doherty, Mary Jo; Schlag, G; Schwarz, N.; Mollan, R. A. B.; Nolan, Patrick; Wilson, David J.

doi:10.1016/0142-9612(94)90210-0

Cited by 70 publications

(50 citation statements)

References 28 publications

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“…Generally, xenografts are one of the alternative graft materials used in different fields for filling osseous defects 11,12) . Nonetheless, an interesting alternative to xenografts is Biocoral ® (natural coral), which has been shown to exhibit osteoconductive and biocompatible properties whereby gradual replacement with newly formed bone occurred after its resorption [13][14][15][16] . In other words, the biomaterials/implants were incorporated into the surrounding tissue by both bone ingrowth into the implant volume and by apposition of bone against the implant surface.…”

Section: Discussionmentioning

confidence: 99%

The bone-healing effect of a xenograft in a rat calvarial defect model

2009

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Bone grafts have been widely used to fill osseous defects in medicine, dentistry, and periodontology. The purpose of this study was to investigate the effects of a xenograft (Unilab Surgibone ® ) on experimentally created parietal bone defects in rats. To this end, 14 rats were employed in the present study and in each of them, 5-mm-diameter defects were created on the parietal bone. The right defect sites were filled with the xenograft material, while the left sites were used as control. After 30 days, the rats were sacrificed and tissue samples were retrieved from the defect sites of the cranium. Dense collagenous tissue was observed in the control area, whereas the xenograft particles were surrounded by a fibrous tissue layer at the implantation site. Based on the findings obtained, it could be concluded that the investigated xenograft seemed biocompatible and could be proposed as a potential material for filling osseous defects.

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Section: Discussionmentioning

confidence: 99%

The bone-healing effect of a xenograft in a rat calvarial defect model

2009

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“…Such porous shells of calcium carbonate have been targeted by materials scientists as having potential significance as lightweight ceramics, catalyst supports, and robust membranes for high-temperature separation technology (34). Biomedical applications include the use of these biomineralized materials for construction of artificial bone in humans (8,30,32), scaffolding supports in tissue engineering (2, 7), complement activation enhancement (29), artificial dental root construction (6,26), and biomedical implants (34). While a general understanding of some of the ecophysiological aspects of calcification and coccolithogenesis in E. huxleyi has been obtained, little information on the life cycle of this organism is available.…”

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confidence: 99%

Induction of Phase Variation Events in the Life Cycle of the Marine Coccolithophorid Emiliania huxleyi

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et al. 2001

Appl Environ Microbiol

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Emiliania huxleyi is a unicellular marine alga that is considered to be the world's major producer of calcite. The life cycle of this alga is complex and is distinguished by its ability to synthesize exquisitely sculptured calcium carbonate cell coverings known as coccoliths. These structures have been targeted by materials scientists for applications relating to the chemistry of biomedical materials, robust membranes for hightemperature separation technology, lightweight ceramics, and semiconductor design. To date, however, the molecular and biochemical events controlling coccolith production have not been determined. In addition, little is known about the life cycle of E. huxleyi and the environmental and physiological signals triggering phase switching between the diploid and haploid life cycle stages. We have developed laboratory methods for inducing phase variation between the haploid (S-cell) and diploid (C-cell) life cycle stages of E. huxleyi. Plating E. huxleyi C cells on solid media was shown to induce phase switching from the C-cell to the S-cell life cycle stage, the latter of which has been maintained for over 2 years under these conditions. Pure cultures of S cells were obtained for the first time. Laboratory conditions for inducing phase switching from the haploid stage to the diploid stage were also established. Regeneration of the C-cell stage from pure cultures of S cells followed a predictable pattern involving formation of large aggregations of S cells and the subsequent production of cultures consisting predominantly of diploid C cells. These results demonstrate the ability to manipulate the life cycle of E. huxleyi under controlled laboratory conditions, providing us with powerful tools for the development of genetic techniques for analysis of coccolithogenesis and for investigating the complex life cycle of this important marine alga.

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“…Generally, xenografts are one of the alternative graft materials used in different fields for filling osseous defects Slotte andLundgren, 1999, Salama 1983). Nonetheless, an interesting alternative to xenografts is Biocoral® (natural coral), which has been shown to exhibit osteoconductive and biocompatible properties whereby gradual replacement with newly formed bone occurred after its resorption (Guillemin et al,1989, Doherty et al, 1994, Yılmaz and Kuru, 1996, Yukna Ra and Yukna CN, 1998. Another xenogeneic, bone-derived implant material is Bio-Oss, which is similar to the xenograft investigated in our studies (Develioglu et al2009(Develioglu et al , 2010.…”

Section: Bioactive Ceramic Biomaterialsmentioning

confidence: 54%