Biocompatibility, osseointegration, antibacterial and mechanical properties of nanocrystalline Ti-Cu alloy as a new orthopedic material

Javadhesari, S. Moniri; Alipour, Siamak; Akbarpour, M.R.

doi:10.1016/j.colsurfb.2020.110889

Cited by 50 publications

(38 citation statements)

References 40 publications

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“…In addition, there is potential in exploring the antibacterial effects of UV irradiation on orthopedic biomaterials typically comprised of titanium alloys, including Ti–6Al–4V. Accordingly, evaluations have been performed on the antimicrobial and bactericidal effects of UV irradiation, at a shorter and lower dosage than in prior applications, to treat Ti and titanium alloy Ti–6Al–4V for utilization in implant surgery [ 140 , 141 ].…”

Section: Strategies To Enhance the Antimicrobial Properties Of Titanium Alloys Through Ultraviolet (Uv) Irradiationmentioning

confidence: 99%

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

et al. 2021

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Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950s. Due to the excellent mechanical tribological properties, corrosion resistance, biocompatibility, and antibacterial properties of titanium, it is getting much attention as a biomaterial for implants. Furthermore, titanium promotes osseointegration without any additional adhesives by physically bonding with the living bone at the implant site. These properties are crucial for producing high-strength metallic alloys for biomedical applications. Titanium alloys are manufactured into the three types of α, β, and α + β. The scientific and clinical understanding of titanium and its potential applications, especially in the biomedical field, are still in the early stages. This review aims to establish a credible platform for the current and future roles of titanium in biomedicine. We first explore the developmental history of titanium. Then, we review the recent advancement of the utility of titanium in diverse biomedical areas, its functional properties, mechanisms of biocompatibility, host tissue responses, and various relevant antimicrobial strategies. Future research will be directed toward advanced manufacturing technologies, such as powder-based additive manufacturing, electron beam melting and laser melting deposition, as well as analyzing the effects of alloying elements on the biocompatibility, corrosion resistance, and mechanical properties of titanium. Moreover, the role of titania nanotubes in regenerative medicine and nanomedicine applications, such as localized drug delivery system, immunomodulatory agents, antibacterial agents, and hemocompatibility, is investigated, and the paper concludes with the future outlook of titanium alloys as biomaterials. Graphic abstract

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Section: Strategies To Enhance the Antimicrobial Properties Of Titanium Alloys Through Ultraviolet (Uv) Irradiationmentioning

confidence: 99%

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

et al. 2021

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“…Low wear resistance and fatigue strength [93]. Formation of bacterial biofilms on the implant's surface [86].…”

Section: Advantages Disadvantagesmentioning

confidence: 99%

“…They also found that their hardness, elastic limit, corrosion resistance, and antibacterial rate increased with increasing copper content. Another study [93] investigated the use of a nanocrystalline Ti-Cu intermetallic alloy as an orthopedic material and evaluated its mechanical, antibacterial, toxicity, corrosion, and osseointegration properties. This alloy was found to have a high hardness (10 GPa), an adequate toughness (8.14 MPam½), an antibacterial rate of approximately 98% (S. aureaus and E. coli), a high cell viability (osteosarcoma cells), and a high osteoblast formation rate, which demonstrates the considerable potential of these alloys in the orthopedic sector.…”

Section: Ti-cu Alloysmentioning

confidence: 99%

Additive manufacturing of Ti6Al4V alloy via electron beam melting for the development of implants for the biomedical industry

Tamayo

Riascos

Vargas

et al. 2021

Heliyon

123

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Additive Manufacturing (AM) or rapid prototyping technologies are presented as one of the best options to produce customized prostheses and implants with high-level requirements in terms of complex geometries, mechanical properties, and short production times. The AM method that has been more investigated to obtain metallic implants for medical and biomedical use is Electron Beam Melting (EBM), which is based on the powder bed fusion technique. One of the most common metals employed to manufacture medical implants is titanium. Although discovered in 1790, titanium and its alloys only started to be used as engineering materials for biomedical prostheses after the 1950s. In the biomedical field, these materials have been mainly employed to facilitate bone adhesion and fixation, as well as for joint replacement surgeries, thanks to their good chemical, mechanical, and biocompatibility properties. Therefore, this study aims to collect relevant and up-to-date information from an exhaustive literature review on EBM and its applications in the medical and biomedical fields. This AM method has become increasingly popular in the manufacturing sector due to its great versatility and geometry control.

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“…The c-myb delivery by the gold nanocomposite has facilitated dental implant osseointegration in ovariectomized rat model (Takanche et al, 2018). Furthermore, nanocrystalline titaniumcopper alloy has demonstrated a strong biocompatibility, antibacterial, osseointegration, and mechanical properties to be a highly beneficial orthopedic material, especially for dental implant application (Moniri Javadhesari et al, 2020). Moreover, silver nanoparticle decorated graphene nanocomposites were identified to possess osteointegration property with enhanced antibacterial activity against an oral pathogen named Aggregatibacter actinomycetemcomitans along with Streptococcus mutans, Candida albicans, and Lactobacillus acidophilus (Peng et al, 2017).…”

Section: Metal Nanomaterialsmentioning

confidence: 99%

Plant-Derived Nanobiomaterials as a Potential Next Generation Dental Implant Surface Modifier

2021

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Dental implants resemble synthetic materials, mainly designed as teeth-mimics to replace the damaged or irregular teeth. Specifically, they are demarcated as a surgical fixture of artificial implant materials, which are placed into the jawbone, and are allowed to be fused with the bone, similar to natural teeth. Dental implants may be categorized into endosteal, subperiosteal, and zygomatic classes, based on the placement of the implant “in the bone” or on top of the jawbone, under the gum tissue. In general, titanium and its alloys have found everyday applications as common, successful dental implant materials. However, these materials may also undergo corrosion and wear, which can lead to degradation into their ionic states, deposition in the surrounding tissues, as well as inflammation. Consequently, nanomaterials are recently introduced as a potential alternative to replace the conventional titanium-based dental implants. However, nanomaterials synthesized via physical and chemical approaches are either costly, non/less biocompatible, or toxic to the bone cells. Hence, biosynthesized nanomaterials, or bionanomaterials, are proposed in recent studies as potential non-toxic dental implant candidates. Further, nanobiomaterials with plant origins, such as nanocelluloses, nanometals, nanopolymers, and nanocarbon materials, are identified to possess enhanced biocompatibility, bioavailability and no/less cytotoxicity with antimicrobial efficacy at low costs and ease of fabrication. In this minireview, we present an outline of recent nanobiomaterials that are extensively investigated for dental implant applications. Additionally, we discuss their action mechanisms, applicability, and significance as dental implants, shortcomings, and future perspectives.

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Biocompatibility, osseointegration, antibacterial and mechanical properties of nanocrystalline Ti-Cu alloy as a new orthopedic material

Cited by 50 publications

References 40 publications

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

Additive manufacturing of Ti6Al4V alloy via electron beam melting for the development of implants for the biomedical industry

Plant-Derived Nanobiomaterials as a Potential Next Generation Dental Implant Surface Modifier

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