Biocompatibility studies of electrospun nanofibrous membrane of PLLA‐PVA blend

Abstract

Electrospinning, self-assembly, and phase separation are some of the techniques available for the synthesis of nanofibers. Of these techniques, electrospinning is a simple and versatile method for generating ultrafine fibers from a wide variety of polymers and polymer blends. Poly L-lactide (PLLA) and Poly (vinyl alcohol) (PVA) are biodegradable and biocompatible polymers which are mainly used for biomedical applications. Nanofibrous membranes with 1:9 ratio of PLLA to PVA (8 to 10 wt % and 10 wt %) were fabricated by electrospinning. The percentage porosity and contact angle of PVA in the PLLA-PVA nanofibrous mat increased from 80 to 83% and from 39 6 3 to 55 6 3 , respectively. The water uptake percentage of PVA nanofibers decreased from 190 to 125% on the addition of PLLA to PVA in the PLLA-PVA nanofibrous mat. The nanofiber morphology, structure and crystallinity were studied by Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD), respectively. The thermal properties were studied by thermogravimetric analysis (TGA) and differential scanning calorimetery (DSC). The biocompatibility studies of PLLA-PVA blend were performed using fibroblast cells (NIH 3T3) by MTT assay method. The release of Curcumin (0.5, 1.0, and 1.5 wt %) from PLLA-PVA blend was found to be $ 78, 80, and 80%, respectively, in 4 days.

Polycaprolactone nanofibers for the controlled release of tetracycline hydrochloride

“…The carrier material for the drugs should be biodegradable, protect the drug from undergoing decomposition and provide controlled release of the drugs [5]. Several drug carriers have been investigated, including cast films [6], nanoparticles [7] and nanofibers [8].…”

Development of a Two‐Tier Fibrous Membrane by Sequential Electrospinning for Effective Air Filtration

“…It clearly shows the major peaks associated with poly l ‐lactide. Peaks characteristic of CH stretching vibrations (2943 cm −1 ), CO stretching vibrations (1752 cm −1 ), COC stretching vibrations (1184 cm −1 ), CO stretching vibrations (1089 cm −1 ) were observed . Figure b shows the FT‐IR spectrum of pure PVP electrospun ultrathin fibers.…”

“…Peaks characteristic of C─H stretching vibrations (2943 cm À1 ), C5 5O stretching vibrations (1752 cm À1 ), C─O─C stretching vibrations (1184 cm À1 ), C─O stretching vibrations (1089 cm À1 ) were observed. [23] Figure 2b shows the FT-IR spectrum of pure PVP electrospun ultrathin fibers. The spectrum reveals the characteristic peaks of O─H stretching vibrations (3313 cm À1 ), bending vibrations of methylene ÀCH 2group (1421 cm À1 ), C─N stretching vibrations (1286 cm À1 ) and the symmetrical stretching of C5 5O groups shows a prominent peak at (1647 cm À1 ).…”

Finite element methods to analyze helical stent expansion

“…Materials that can be used in biodegradable stents must be biocompatible [Lally, 2005] and balloon-expandable stents should demonstrate appropriate mechanical properties to support the artery and undergo plastic deformation during deployment [Lally, 2005]. Potential candidate materials for BDE stents are limited to drug delivery and loadcarrying structural polymers such as poly-L-lactide-CO-glycolic acid (PLGA) and poly-L-lactic acid (PLLA), where PLLA is one of the most widely studied biocompatible materials [Athanasiou, 1996, Elakkiya 2013. Although current BDE stents may minimize FBRs, they cannot prevent arterial injuries incurred during deployment.…”