Biocompatibility Studies of Hollow Fiber Plasma Filtration for Hepatic Assist

Low-temperature plasma separation by cross-flow filtration with microporous glass membranes

“…Differences in the critical hemolytic points of various membranes indicate differences in mean pore size, pore size distribution, and pore shape (Malchesky et al, 1983). With polymer membranes such as poly(methyl methacrylate) and poly(vinyl alcohol) and cellulose acetate membranes, transmembrane pressure should not exceed approximately 6.6 kPa to prevent hemolysis (Smith et al, 1979;Hosokawa et al, 1983;Horiuchi et al, 1981). Operation at higher transmembrane pressures or uncontrolled plasma separation rates will lead to decreased flux rates, low sieving for macromolecules, membrane plugging, and for some membrane filters hemolysis (Malchesky et al, 1983).…”

Axial Changes of Blood and Plasma Flow, Pressure, and Cellular Deposition in Capillary Plasma Filters

“…August 1981 one obtains the following results. which are expressed in dimensionless form:+ K-'sinh X + :H,)(cosh X) -cash X)X illustrates the results of computations using equations (24) through (26) for plasma and equa-9 Q F p 2 Q,9 p,, tions (27) through (29) for blood. The quantities a and 8 are plotted versus X for varying K. The dimensionless variable X was chosen as the independent variable and represents the distance x from the inlet of the fiber (or filter) assuming that the properties of the fibers, q and r p , and the property of the fluid, B, are constant.…”