Biocompatibility Study of Polymeric Biomaterials

Abstract

Polymeric hydrogels are used as wound dressing material since these materials show advantages such as pain relief, exudates absorption, barrier to microorganisms, permeability, and others. This article shows the results obtained in a study aiming to know the biological performance of different polymeric materials to be used in contact with skin: PVP hydrogels and acrylate adhesive. The biocompatibility was determined by in vitro assay of cytotoxicity and in vivo assay by using the contact test of irritability in rabbits. All the tested samples presented no toxicity and no dermal irritation.

Polyelectrolyte complex materials from chitosan and gellan gum

“…Highly flexible materials and strong adhesives are needed to apply on elbow and finger joints 49 . Biocompatibility of wound materials or implants is involves low or no toxicity or carcinogenic effects, either locally or systemically in local tissue [50][51][52][53] .…”

Minimally Invasive Protein Delivery with Rapidly Dissolving Polymer Microneedles

“…Third, PVP already has a long history of clinical use as a blood plasma expander. [17,18] Finally, the vinyl pyrrolidone monomer is liquid at ambient conditions, which facilitates processing at mild temperatures without the need for an organic solvent to fill the microneedle mold. Using this approach, microneedles were produced to have a range of micrometer-scale feature sizes, depending on the mold geometry.…”

Immunologically Active Biomaterials for Cancer Therapy

“…Natural materials, including collagen protein derived from the connective tissue of animals, chitosan polysaccharides extracted from the exoskeleton of crustaceans and alginate polysaccharides isolated from seaweed, have been fashioned into gels and utilized as drug delivery devices or as depots for cell transplantation (Huebsch and Mooney 2009;Ali and Mooney 2006;Eiselt et al 2000;Miyata et al 1992;Li and Xu 2002). These materials have been utilized in the clinic for cosmetic and wound care applications with established biocompatibility (Ali and Mooney 2006;Eiselt et al 2000;Rogero et al 2003;Majeti and Kuma 2000;Li et al 2005). Further, the concentrations, molecular weight and crosslinking density of collagen, chitosan and alginate macromolecules can be modified to develop gels with defined degradation rates, stiffness, and functional groups, which can influence the release kinetics or binding of immunostimulatory biomolecules for drug delivery, or the viability and activation state of cells interacting with the material matrix (Ali and Mooney 2006;Eiselt et al 2000;Miyata et al 1992;Li and Xu 2002;Rogero et al 2003;Majeti and Kuma 2000;Li et al 2005;Lee et al 2000a;Chevallay and Herbage 2000;Borzacchiello et al 2001;Bodnar et al 2005).…”