Biocompatibility tests on a novel glass–ceramic system

Abstract

The aim of this study was to look at the bone bonding potential of six formulations of a novel glass-ceramic system. Cylinders of the ceramics were implanted in rabbit tibiae for 4 and 7 weeks. Histological tests, both quantitative and qualitative, as well as push-out tests, were carried out during the bonding assessment. Bone growth was quite prolific, even at 4 weeks, as evidenced by growth up to and along the implant surfaces. The interfacial shear strengths compared well with other biomaterials in use as endosseous implants. Therefore it seems pertinent to pursue further long-term experimentation with this material.

Bioactive Composites Based on Calcium Phosphates for Bone Regeneration

“…Certain glass-ceramics have shown to induce very good apposition of bone at the bone/material interface, showing direct contact between osteoblast cells and mineralized layers at the material surface. Moreover, a faster bone proliferation than in the case of HA has been observed [57,58]. According to Hench [62], bioactive materials are able to form a carbonated HA (CHA) bone-like layer on their surface.…”

Crystallographic characterization of fluorapatite glass-ceramics synthesized from industrial waste

“…Apatite-based glass-ceramics have been extensively studied in recent decades. They show excellent mechanical properties, bioactivity, and compatibility for biomedical applications (Wolfe and Boyde, 1992). They can form an apatite layer and strong chemical bonds at the bone or tooth interface with the implant (Denry and Holloway, 2014).…”